LOCUS HUMFABP 5204 bp DNA linear HUM 08-NOV-1994
DEFINITION Human, intestinal fatty acid binding protein gene, complete cds,
and an Alu repetitive element.
ACCESSION M18079 J03465
VERSION M18079.1
KEYWORDS Alu repeat; fatty acid binding protein.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 5204)
AUTHORS Sweetser,D.A., Birkenmeier,E.H., Klisak,I.J., Zollman,S.,
Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
TITLE The human and rodent intestinal fatty acid binding protein genes. A
comparative analysis of their structure, expression, and linkage
relationships
JOURNAL J. Biol. Chem. 262 (33), 16060-16071 (1987)
PUBMED 2824476
COMMENT Original source text: Human DNA (library of T.Maniatis), clone
lambda-HIFABP.
Draft entry and computer-readable sequence for [1] kindly provided
by D.Sweetser, 19-JAN-1988.
FEATURES Location/Qualifiers
source 1..5204
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/map="4q28-q31"
prim_transcript 1028..>4393
/note="FABPI mRNA (alt.) and introns"
prim_transcript 1053..>4393
/note="FABPI mRNA (alt.) and introns"
CDS join(1089..1155,2350..2522,3546..3653,4098..4148)
/note="fatty acid binding protein"
/codon_start=1
/protein_id="AAA52417.1"
/translation="MAFDSTWKVDRSENYDKFMEKMGVNIVKRKLAAHDNLKLTITQE
GNKFTVKESSAFRNIEVVFELGVTFNYNLADGTELRGTWSLEGNKLIGKFKRTDNGNE
LNTVREIIGDELVQTYVYEGVEAKRIFKKD"
gene 1089..1155
/gene="FABP2"
exon <1089..1155
/gene="FABP2"
/note="fatty acid binding protein; G00-119-127"
/number=1
intron 1156..2349
/note="FABPI intron A"
exon 2350..2522
/number=2
intron 2523..3545
/note="FABPI intron B"
exon 3546..3653
/number=3
intron 3654..4097
/note="FABPI intron C"
exon 4098..>4148
/note="fatty acid binding protein"
/number=4
repeat_region 4466..4742
/note="Alu repeat"
repeat_region 4466..4472
/note="5' direct repeat"
repeat_region 4736..4742
/note="3' direct repeat"
BASE COUNT 1770 a 867 c 836 g 1731 t
ORIGIN 156 bp upstream of HindIII site; chromosome 4q28-q31.
1 gtaatatctt gggcaagccc tagagcttct ttcctgaccc ttagttaata agatgttatc
61 tggtcacatt cagtcacaat aatagactca ttttagtaat aaacatctta agactagtaa
121 ttaaaactct ttacttcaca ccaagtttcc tccccaagct tggcctgttc ctggctggca
181 gcctgaagta gggaaaggag agatatggtg accttttctt tgtacctttc tagctaccct
241 ctataccctg accccacata cataattgag ctgtggcttc tgactctact gggtttgggg
301 atgagaggca gtgagagtaa aatgaaggag tggttttaat taatggcaca gctaaaactg
361 gattttgttc tctctgcaca tggcagatgt ttaaagctca ttctttcttt tatgcaagtt
421 tttacaccat ccagcctcat ttgtacctct tgaatttttg ctcagtggcc tatcaccatt
481 caggatcaag acaaaaatca atgagcactt attgtgtgtc atgcacccta caaagtgcca
541 ggatatttat ccaaactcct ggcaatgcta aacacaatgc aaaaagacat attagaaaac
601 gaatcttatt aactttagct tttcaactgt atttcatcat aaagtcttac tttacaagat
661 aattgctgtt gtgaaaaagg gaaaggtcat ggtctcattt cccagatgtt atttgatata
721 tgctataaat tatattacct ccaacatagt ctgcactttg aacttagaaa aacaatcttc
781 agacggcatg cattctaatt cttgaaataa gtatgcccac aaactgtagt ttaagacaga
841 ataggtatgc ttctcatgtt ttaattcagt tgaatttcag aagatctcag gaatgtacag
901 aacgagaatt aagaattaat aagaataaga attaattaat tgcttgacat agagtagtta
961 ggtgatttcc tgaactttaa gcttccacat cacagtatga agttggttca agataagaaa
1021 tataataaat tctcgcccaa ggacagacct gaatctctag ctgcctagag gctgactcaa
1081 ctgaaatcat ggcgtttgac agcacttgga aggtagaccg gagtgaaaac tatgacaagt
1141 tcatggaaaa aatgggtaaa gactttattt ctttgtggct cattctttgc tttcttacaa
1201 acatttttct ttctaactcc taaatctcta ggagattaca gatagcttac agatagctcc
1261 tgatgtggta gagagggatc cagaagatgt tcagaggagg gaaaccatat tttcccttct
1321 tacattagga agaatccact atctcactaa tggaagaaaa gattctttga gtgctgttct
1381 ctgaaacaca ccaaaaagat ccagaaatgt ttccttcact ctttaactga aaaatgactt
1441 tttttgttgt ttacagtaag aaaatggcag cgtgtaatga taacttccag atctgaaaat
1501 gttaaattct aggagatgga aaaacaaaga ccatataaga aagtaatgga aaaagttctc
1561 ttaaaattta tagctctgaa taagttagat ttaattctga tttcttctaa cttaaaaaag
1621 ttttggaata atcttgagaa gctgtgtagt tttctccagg gcgtttaatt taactgattt
1681 ataatttgat accaatactc tggcagccca tatactatac aagataggca aacaaatttg
1741 tgtcattccc ctaaaagaaa aatctgcatc aattatagct tacagtttag gaactctaag
1801 tttaaattta taaaagttgt agattcttat agtgattttg gcttaatatt tgctaatttt
1861 ctcatttttg tgtcagaaag aaatgccaca agaagcaaat agaactataa agttcaaaat
1921 gttaaagcca ctaagaaaaa caaaggggca tttaagaaaa aagaatactg tatatgtgga
1981 attaaagatg tgcttcctta taaatatatg aatatacatt ttaatccttc atttaatatt
2041 tctagaattt gatttactta acactgaaat gaacagtttg ttaatcttat taaggttgct
2101 cagctctaag attctataat tctgtactct acttaatttt tctcaagtta tggaaaaaca
2161 actttaatca gttctcttga tcggattgaa cctgaacttc tatagaagca atctgaatgt
2221 tcttgtgcaa aggcaatgct accgagtttt cttcccaccc tcaaaataaa caaacaaaac
2281 ataacttgga aaaataaaca cttcctatgg gatttgactt tattttctcc attgtcttac
2341 cttttacagg tgttaatata gtgaaaagga agcttgcagc tcatgacaat ttgaagctga
2401 caattacaca agaaggaaat aaattcacag tcaaagaatc aagcgctttt cgaaacattg
2461 aagttgtttt tgaacttggt gtcaccttta attacaacct agcagacgga actgaactca
2521 gggtaagaat tttttttttt atgagcaatg cattcttgat ttttctaccc aatattaaaa
2581 tgatttctgc tctatttcat tggatggttt aattaatgca ggtctccttc actaactgaa
2641 gaagccaatg aagtttgtct acattatata ttacacaaat tggcagggta tttaaatatg
2701 cttttatttt tatacgcatc tgtgaagaat ctgaattgaa cagtaagaat tagaaaacta
2761 tcttttgaat gactgaatat agacctattc ataaagaaat ttaaaactgt gtttttaaac
2821 agtacagcaa aagaagcctt tagagttaat atgtaactta actgtaacat gttgaaataa
2881 taaaagaaat gaatagatga acaaatgagt gagttaccaa atggaaagat ttgatgtatt
2941 gtaggtcatt gggagtgtac cttttcatgt ttaagataac acattttagg aagtcatcat
3001 tttcaacaaa ttttttaaaa acttttttta gcctcaacat ttttctattt aaattacatg
3061 tttgtaatga caatttaact actgaatgtt ttatcgtaag ttatgtcttt ccttaattag
3121 taccacaatc acacaaatta aaacaagcac aggttattaa catctccgtg aaactaattt
3181 taaccatgac tatatttctg gacacgtaac atgaaagatt cagaaagaag tgctgctcat
3241 ctgccttaaa attcagcgta tggaaattat tgaagagaac aagcataatg gttatcaaca
3301 catactctgt agcccaatgg cctaggttca atcctcactc tgtgacttta ggtgaatcac
3361 tgtgccattt tacagtctcc tcttctgcaa agtagagata gtagtatcag tttcataggg
3421 tcaccatgaa gattaaatga aaaagtgtgt ctacagaact cagaacagtg cctgacatgt
3481 gtaagaccct aataaatgcc attattatta ttattattat tattattatt attattatta
3541 tgtaggggac ctggagcctt gagggaaata aacttattgg aaaattcaaa cggacagaca
3601 atggaaacga actgaatact gtccgagaaa ttataggtga tgaactagtc caggtgagtt
3661 gtcaaattta tagctatttt caaaaggcaa aaattactac aaaacaataa tttttgtcac
3721 tgctgagcca gatcttcagt aaactgacta cttcttttct cataaatctt actgatttta
3781 aaaatattgt atagctattt tctgatgcct atttactaaa gacaacttat atatgtcaaa
3841 taatcaatgc ctattttaac tgaaaatata aatgactaca aaccaacatg tgttttaaaa
3901 tggctgtatc ccatatctgt ataaatcttg ctatcaagta caagaaaaaa ttgtataaac
3961 tcatactcat ataatatata tgaatatata atataaaaat agtataaact catatagtat
4021 aaaactataa tactactttt tcttaactta gatgtaaacc ttaaagataa attcttctgt
4081 ttgttaacac ctttcagact tatgtgtatg aaggagtaga agccaaaagg atctttaaaa
4141 aggattgagc attattcttg gcgcacagtc caaaatacaa attggacaga agatctatat
4201 tgtaccagaa ctgtttattt caccccatca agtataaggt tactgattga ttggtccttt
4261 tataaacatt ggtatatttc cattcatgcc aaagcaaaag aagtaaaagc taattaggat
4321 ttaatttgtt ttatattctc taagatatat atttactaaa agaatttgtg acattttaaa
4381 aaacaaaaat aaatattgca tccatgttgc tttatatgta gccttgcctt ttaaaagaaa
4441 aagtatgtga atatgaattg acagattgtt ttcgtagaga gagggtctta ctctttcact
4501 caggctggaa tgcagtggag agatcatagc tcactgtaac ctcaaactcc tggactcatg
4561 caatcttcct gcctcaggct tctgagtagc taggactatg ggtacattcc acagtgccca
4621 gctaattttt gttttgtttt ctttttattt tttttagaga tggggtcttg ctatattgcc
4681 caggctggtc ttgaacccct ggcctcaagc aatcctcctg cctcagcctc tcaagttgtt
4741 tttttcttta catttgataa actaaaagca taggctgcat atgagtcttt aacatcttga
4801 actggttgtg aataattttc tggcactggt tgtaagtaat atctattatt ataaaaataa
4861 tatatgctca accagaaaac ttagaaataa gaaacacaaa tgtaaaataa gtatttccat
4921 aactcataat ccagagataa ttgccattct gattttgata gatatcctct cagctctctt
4981 ccctgggggc agatatttcc caatacatac cactttgaat aggatgatag gaaataaatg
5041 atgtactaca ttaaattaaa ttattgtatt acatttttgt acacatcagt cattcccagg
5101 cttggctgaa aatcaggatc atctgagaaa cttaaacaat ttctgcattc ttaatctcca
5161 ctgttattct attatatcag aatcgctaat agaaccaaga attc
//
LOCUS RATFABP 3013 bp DNA linear ROD 27-APR-1993
DEFINITION Rat intestinal fatty acid binding protein gene, exons 1 and 2, and
a B2 repetitive element.
ACCESSION M18080 J03465
VERSION M18080.1
KEYWORDS B2 repetitive sequence; fatty acid binding protein.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 3013)
AUTHORS Sweetser,D.
JOURNAL Unpublished
REFERENCE 2 (bases 917 to 1217)
AUTHORS Sweetser,D.A., Birkenmeier,E.H., Klisak,I.J., Zollman,S.,
Sparkes,R.S., Mohandas,T., Lusis,A.J. and Gordon,J.I.
TITLE The human and rodent intestinal fatty acid binding protein genes. A
comparative analysis of their structure, expression, and linkage
relationships
JOURNAL J. Biol. Chem. 262 (33), 16060-16071 (1987)
PUBMED 2824476
COMMENT Original source text: Rat (Sprague Dawley) intestinal epithelial
lining DNA, clone lambda-RIFABP.
Draft entry and computer-readable sequence for [2] kindly provided
by D.Sweetser, 19-JAN-1988.
FEATURES Location/Qualifiers
source 1..3013
/organism="Rattus norvegicus"
/mol_type="genomic DNA"
/db_xref="taxon:10116"
repeat_region 195..406
/note="B2 repeat"
prim_transcript 1155..>3013
/note="FABPI mRNA (alt.) and introns"
prim_transcript 1179..>3013
/note="FABPI mRNA (alt.) and introns"
CDS join(1215..1281,2541..2713)
/note="fatty acid binding protein"
/codon_start=1
/protein_id="AAA41133.1"
/translation="MAFDGTWKVDRNENYEKFMEKMGINVVKRKLGAHDNLKLTITQE
GNKFTVKESSNFRNIDVVFELGVDFAYSLADGTELT"
exon <1215..1281
/note="fatty acid binding protein"
/number=1
intron 1282..2540
/note="FABPI intron A"
exon 2541..>2713
/note="fatty acid binding protein"
/number=2
intron 2714..>3013
/note="FABPI intron B"
BASE COUNT 977 a 534 c 588 g 914 t
ORIGIN 1 bp upstream of EcoRI site.
1 gaattcctta atttgcataa tttactcaca ttagtcaaga acaaaacatt taaaaaaata
61 aagaggtagc tgatatgtaa atactgaaaa cacattcggt gaaaagattc aaacataaaa
121 agactacctg atatataatt atatttgtat gaaatgtcca tagaggtaga aagtggatgg
181 gaacctaatg gtctaaaaat agaaaatgag agctggagag atggctcagc agttaaaagc
241 actgactgct cttccagagg acctgagttc aattcccagc aaccacatgg tggctcacaa
301 ccatctgtaa tgggatctga tgccctcttc tggtgtgtcc aaagacagcg gtggtgtact
361 cacatacata aagtaaaaaa ttctttaaaa aaaaaataga aaatgaaaac ccactgctta
421 aaatgtatgc agtttctttt ggggataatg acactgtttc agaatatgat aatagagatg
481 tttgggcaaa tagtttatat actaaatttt agattgattt gatatcaata aaataacctt
541 aggaacacag aaaaattaaa atacattttt tagttccaat aatcacttaa actttaactt
601 tgcaattgca cttttgtata gtttgttcaa ctcctgttaa agattcgtgg tataagtctc
661 acatcccagt tgtttgacgt ttcttacaaa tgatacatag ttacataatt acatagttac
721 acctgctgta gagtgtgcac tttgaacctg taaatagaaa agtatcttga gggttttttc
781 ttcttgttgt tgtttgtctg tttggtttgg tttatcgcct gattcattct tgttgtttgt
841 cttttggctg gagtggaact ccttattaca gcaggctaga attgtctgcc tctgcttctg
901 gagagctcgg attaaaggtg gaagccatca cacttgaccc taattcttgg aataaaaatg
961 cctacatgct gtagtcggag acagagtagg tatggttacc aaatttgaat gcagttgaat
1021 ctcagcaata gattcaaaga aagcactaga agagaaacta aaggggcctg gcatgcaaaa
1081 ctgccaggtt atctcttgaa ctttgaactt ccacatcatg gtatgaattg gttcgaagat
1141 aagaaataga ataaattctc tctagtggac aggaccgaat ctctgctttc ctagaggcac
1201 acacagctga catcatggca tttgatggca cttggaaagt agaccggaat gagaactatg
1261 aaaagttcat ggagaaaatg ggtaagggct ggcttcctgt ctatttgctt tctcctgtct
1321 gtagttactg aatgacttgg gatgtggtaa ggttctaggc gtgattgttc agagccagga
1381 aacccatatt tgcacttcct gctttaggaa gaatatcttg ttcgctaggg caagccctgc
1441 tctctgaaac acaccaagga agagccacct gtggtttctt cccttgcctg ataattgtgt
1501 aaaaactgac atgtttgtgt tcatttaaaa aagaatagta tggtgagtta tgataatttc
1561 aagagcttaa aaaaaaaaaa accactagcc tataggggat ttaaaaagca aggatctttt
1621 aataaagaaa agaattttgt caaaactcag cttgaataaa tcatatggaa ttcttttctc
1681 tgacttatct aacttcagga ataagtataa aaagcggtat attcttcaca gaggtgtaat
1741 ttaacaatat tatacatatt tgctaatatc ctggtagcct acactacaaa ctgggcaaac
1801 atgcttcatt tctcaaaata aagcctgaat aaattatctc tttcacttga gggattgtga
1861 attgaagttt ataaaatttc gtattataat gaattaatca taaaatgtca ttataatttt
1921 tctggattag gccaatgagg aatgctacaa agagtcaata gaattacgag gcaaacaaac
1981 catggtgtac gccagggatc tcaacagtcc tgaagagtga aaagagagga ctgtgagtta
2041 taggctagcc tgtgctatgc agtaagtttg gggcctgcct gagttacaca ctaagacctg
2101 gttccaaaca acaacaaaat aaatacaagc aattttgaaa gcaaagtagt gttggaaata
2161 aatactcaaa cctgagcgtg tctctcttta atatatcaat atgcctctta atacttcact
2221 tgacgttgct gaaatttgcc tgatcatgga agcgaaaggt cggctaatct cgttcatgct
2281 atccagggct gaggtgctac cgtttgtggc ttcatttaca ttttcttact ttggaaaagc
2341 agcttgaacc ttccctggat ctgccagtgc ttctcccttt ttctctagaa gcctgttggt
2401 gctgtttgca tacatgacac tatttgcttt ttcttccaca cccacaaaat aaagatgagc
2461 aaatggaaac agaacttggg aagagaaacc ctttgggtga cattctaatc tcacgctccc
2521 tccatctctc tcctttgcag gcattaacgt ggtgaagagg aagcttggag ctcatgacaa
2581 cttgaaactg acgatcacac aggaaggaaa taaattcaca gtcaaagaat caagcaactt
2641 ccgaaacatt gatgttgtgt ttgaactcgg cgtcgacttt gcctatagtc tagcagatgg
2701 aacagaactc actgtaagac attttcatag gcagaacatt ttgatttttt tttttaccaa
2761 tacaaaatgg tttatctcat ggaaagagca gctaatgcaa accttcttca tttactgaaa
2821 aggccgcaaa tatcttatat tacgcacatt gacaaaatgt ttaatatagt acttcactat
2881 gtatgtgtct gtgaaaaagc tatactgaat aataagactc agatcaaccc tctcagattg
2941 actgagtgta gggacagtct caaggaaatg tgaagttcta tattttcaac tctacatgca
3001 ggtggccgaa ttc
//