LOCUS HUMTKFER 2950 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human tyrosine kinase (FER) mRNA, complete cds.
ACCESSION J03358
VERSION J03358.1
KEYWORDS c-myc proto-oncogene; tyrosine kinase.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2950)
AUTHORS Hao,Q.L., Heisterkamp,N. and Groffen,J.
TITLE Isolation and sequence analysis of a novel human tyrosine kinase
gene
JOURNAL Mol. Cell. Biol. 9 (4), 1587-1593 (1989)
PUBMED 2725517
COMMENT Original source text: Human fibroblast, cDNA to mRNA.
Draft entry and computer-readable sequence for [1] kindly submitted
by J.Groffen, 31-MAR-1989.
The FER gene contains regions homologous to the highly conserved
tyrosine protein kinase domain of the other oncogenes and growth
factor receptors, but lacks a clear transmembrane region,
indicating that it encodes a tyrosine kinase of the nonreceptor
type.
FEATURES Location/Qualifiers
source 1..2950
/db_xref="H-InvDB:HIT000191154"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="5q21"
gene 1..2950
/gene="FER"
mRNA <1..2950
/gene="FER"
/product="FER mRNA"
CDS 385..2853
/gene="FER"
/note="tyrosine kinase (FER)"
/codon_start=1
/protein_id="AAA61190.1"
/db_xref="GDB:G00-125-243"
/translation="MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYAS
TLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTM
MIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAK
GKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEM
IKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQE
IEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELE
KRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQEND
GKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSAVGSSALSDMISI
SEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQ
YVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILG
ELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLI
GVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIH
RDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSE
SDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWD
YKPENRPKFSELQKELTIIKRKLT"
BASE COUNT 1017 a 535 c 636 g 762 t
ORIGIN
1 gtcacaccct cgaataatga cgcataccta tcctactgtt actgatcacc tagtaataat
61 cttgtagttc acattactca tttttcacca aattcttttg gtgaaggacg cttcagaaac
121 ggccatcact gaagagcaga cccgtttggg ttctccacgc attctagact cccgaagagc
181 tcatgttttt tggctagacc tatgaccatt ttcgctagac ttcactgcac gttttctcaa
241 gtatcttctt tgtccctaat gtgtgacacc tcatcatgga cacgctactt tagctaaggc
301 atgaccagca atgaacagta gtaagatatg tgctgattag aaggctcact tgtgcagtgt
361 ggaggataac cagtgcctta caaaatgggg tttgggagtg acctgaagaa ttcacatgaa
421 gcagtgttaa aattgcaaga ctgggaatta cggttactgg aaacagtaaa gaaatttatg
481 gccctgagaa taaaaagtga taaagaatat gcatctactt tacagaacct ttgtaatcaa
541 gttgataagg aaagtactgt ccaaatgaat tatgtcagca acgtatccaa gtcttggcta
601 cttatgattc agcagacaga acaacttagt aggataatga agacacatgc agaggacttg
661 aactctggac ctttacacag gctcaccatg atgattaagg acaagcagca ggtgaagaaa
721 agttacatag gtgttcatca gcagatagag gcagagatga tcaaggttac caaaacagaa
781 ttggagaagt taaaatgcag ctatagacaa ttaataaaag aaatgaattc tgccaaagag
841 aaatataaag aagctttagc taaagggaag gaaactgaaa aggccaagga acgatacgac
901 aaagccacaa tgaaacttca tatgttgcac aatcagtatg tattggcgtt gaaaggggca
961 cagctccatc agaatcagta ttatgatatc acacttcccc tgcttctgga ctccttacaa
1021 aagatgcaag aagaaatgat aaaagcactc aaaggtatat ttgatgaata cagccagata
1081 accagtcttg tcacagagga aatagtgaat gtccataaag agattcaaat gtcggttgaa
1141 cagatagatc ctagtacaga atacaataat ttcatagatg ttcacagaac aacggctgct
1201 aaagaacaag aaatagagtt tgatacttcc ttactggaag aaaatgaaaa tcttcaggca
1261 aatgagatca tgtggaataa cttaacagca gaaagtttgc aagtaatgtt gaaaacgtta
1321 gcggaagaac ttatgcaaac acagcagatg cttttaaaca aggaggaggc tgttttggag
1381 ttagagaaga gaattgaaga atcttctgaa acttgtgaga agaagtctga tattgtgctt
1441 ctgctaagcc aaaaacaggc acttgaagaa ctgaaacagt cagtccagca gctgagatgc
1501 actgaagcaa agttttcagc acagaaggaa ttactagagc aaaaagtgca agaaaatgat
1561 gggaaagagc cacctccagt agtaaattat gaagaagatg cacgatcagt tacatctatg
1621 gaaagaaagg agaggctatc caaatttgaa tctattcgtc attcaattgc tggaataatt
1681 aggtctccaa aatctgcagt gggctcttca gcactttctg atatgatctc catcagtgag
1741 aagcctttgg cagaacagga ctggtaccat ggtgcaattc ccagaataga agctcaagaa
1801 ctgttaaaaa aacaaggaga ctttttggtg cgagagagtc atgggaaacc tggtgaatat
1861 gtcctttctg tatattctga tggacagagg agacatttta tcatacaata tgttgataac
1921 atgtatcgat tcgagggcac tgggttttca aacattcctc aacttataga tcatcactat
1981 acaacaaaac aggtcatcac taagaaatca ggtgtagttc tgctgaatcc tattcctaag
2041 gacaagaaat ggattctcag tcatgaagat gtcatattgg gagaattact gggcaaggga
2101 aattttggtg aagtatataa gggcacatta aaggataaaa cttctgttgc tgttaaaaca
2161 tgtaaagaag atcttcctca ggaattgaaa ataaaatttt tacaagaagc caaaattctc
2221 aagcaatatg atcatcccaa tattgtcaaa cttataggag tttgcacaca aagacagcct
2281 gtctacatca ttatggaact ggtttcagga ggtgatttcc tcacctttct gagaaggaag
2341 aaggatgaac taaaactcaa acagttagtg aaattttcat tagacgctgc tgctggtatg
2401 ttgtatctcg agagtaaaaa ctgtatacac agggaccttg ctgcaagaaa ctgcctggta
2461 ggtgaaaata atgttctgaa aatcagtgac tttggaatgt ctcgtcaaga ggatggtgga
2521 gtgtattcat cttctggctt aaagcagatt cccattaaat ggacagcacc ggaagctctt
2581 aattatggga gatacagttc agagagtgac gtgtggagct ttggcatcct tctctgggag
2641 accttcagct taggggtttg tccgtaccct ggaatgacaa atcagcaagc aagagagcaa
2701 gtagaaagag gataccggat gtcagctccc cagcactgtc cagaggatat ttccaaaatc
2761 atgatgaagt gttgggatta taaacctgaa aatcgcccta agttcagtga acttcagaaa
2821 gagctcacta tcatcaagag aaaactcaca tagtgacagg atggcgccaa actcagcctt
2881 caggactctg tcctccagca gagtaacatt attgttctca ttaacaatga atttatacca
2941 cattaccttc
//