LOCUS HUMTHRA2A 2015 bp mRNA linear HUM 14-JAN-1995
DEFINITION Human c-erbA-alpha-2 gene encoding thyroid hormone receptor type
alpha-2 mRNA, complete cds, clone hTR-alpha-2.
ACCESSION J03239
VERSION J03239.1
KEYWORDS thyroid hormone receptor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2015)
AUTHORS Nakai,A., Seino,S., Sakurai,A., Szilak,I., Bell,G.I. and
DeGroot,L.J.
TITLE Characterization of a thyroid hormone receptor expressed in human
kidney and other tissues
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85 (8), 2781-2785 (1988)
PUBMED 3357890
COMMENT On Apr 15, 1994 this sequence version replaced gi:339664.
Original source text: Homo sapiens kidney cDNA to mRNA.
Submitted in computer readable form by L.J.DeGroot 11-MAY-1988.
FEATURES Location/Qualifiers
source 1..2015
/db_xref="H-InvDB:HIT000191144"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="Unassigned"
/tissue_type="kidney"
gene 1..2015
/gene="THRA2"
CDS 58..1530
/gene="THRA2"
/note="The AAs encoded by bases 217-418 bind to DNA and
the AAs encoded by 640-1228 bind thyroid hormone"
/codon_start=1
/product="thyroid hormone receptor"
/protein_id="AAA61176.1"
/db_xref="GDB:G00-118-883"
/translation="MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIP
SYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKI
TRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEP
TPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEF
TKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTL
SGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLC
VDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGS
LGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRS
GILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP"
polyA_site 2015
/gene="THRA2"
/note="G00-118-883"
BASE COUNT 452 a 567 c 590 g 406 t
ORIGIN Chromosome 17; 433 bp upstream of XbaI site.
1 gtggcccacc ccagtctctt ggcgtgctgg agggcatcct ggatggaatt gaagtgaatg
61 gaacagaagc caagcaaggt ggagtgtggg tcagacccag aggagaacag tgccaggtca
121 ccagatggaa agcgaaaaag aaagaacggc caatgttccc tgaaaaccag catgtcaggg
181 tatatcccta gttacctgga caaagacgag cagtgtgtcg tgtgtgggga caaggcaact
241 ggttatcact accgctgtat cacttgtgag ggctgcaagg gcttctttcg ccgcacaatc
301 cagaagaacc tccatcccac ctattcctgc aaatatgaca gctgctgtgt cattgacaag
361 atcacccgca atcagtgcca gctgtgccgc ttcaagaagt gcatcgccgt gggcatggcc
421 atggacttgg ttctagatga ctcgaagcgg gtggccaagc gtaagctgat tgagcagaac
481 cgggagcggc ggcggaagga ggagatgatc cgatcactgc agcagcgacc agagcccact
541 cctgaagagt gggatctgat ccacattgcc acagaggccc atcgcagcac caatgcccag
601 ggcagccatt ggaaacagag gcggaaattc ctgcccgatg acattggcca gtcacccatt
661 gtctccatgc cggacggaga caaggtggac ctggaagcct tcagcgagtt taccaagatc
721 atcaccccgg ccatcacccg tgtggtggac tttgccaaaa aactgcccat gttctccgag
781 ctgccttgcg aagaccagat catcctcctg aaggggtgct gcatggagat catgtccctg
841 cgggcggctg tccgctacga ccctgagagc gacaccctga cgctgagtgg ggagatggct
901 gtcaagcggg agcagctcaa gaatggcggc ctgggcgtag tctccgacgc catctttgaa
961 ctgggcaagt cactctctgc ctttaacctg gatgacacgg aagtggctct gctgcaggct
1021 gtgctgctaa tgtcaacaga ccgctcgggc ctgctgtgtg tggacaagat cgagaagagt
1081 caggaggcgt acctgctggc gttcgagcac tacgtcaacc accgcaaaca caacattccg
1141 cacttctggc ccaagctgct gatgaaggag agagaagtgc agagttcgat tctgtacaag
1201 ggggcagcgg cagaaggccg gccgggcggg tcactgggcg tccacccgga aggacagcag
1261 cttctcggaa tgcatgttgt tcagggtccg caggtccggc agcttgagca gcagcttggt
1321 gaagcgggaa gtctccaagg gccggttctt cagcaccaga gcccgaagag cccgcagcag
1381 cgtctcctgg agctgctcca ccgaagcgga attctccatg cccgagcggt ctgtggggaa
1441 gacgacagca gtgaggcgga ctccccgagc tcctctgagg aggaaccgga ggtctgcgag
1501 gacctggcag gcaatgcagc ctctccctga agccccccag aaggccgatg gggaaggaga
1561 aggagtgcca taccttctcc caggcctctg ccccaagagc aggaggtgcc tgaaagctgg
1621 gagcgtgggc tcagcagggc tggtcacctc ccatcccgta agacctcctt cccttcctca
1681 gcaggccaaa catggccaga ctccttgctt tttgctgtgt agttccctct gcctgggatg
1741 cccttccccc tttctctgcc tggcaacatc ttacttgtcc tttgaggccc caactcaagt
1801 gtgcacctcc ttccccagct cccccaggca gaaaatagtt gtctgtgctt ccttggttca
1861 tgcttctact gtgacactta tctcagctgt tttataatta gtcgggcatg agtctgtttc
1921 ccaagctaga ctgtgtctga atcatgtctg tatccccagt gcccggtgca gggcctggca
1981 tagagtaggt actccataaa aggtgtgttg aattg
//