LOCUS HUMCN4GEL 2733 bp mRNA linear HUM 27-APR-1993
DEFINITION Human collagenase type IV mRNA, 3' end.
ACCESSION J03210
VERSION J03210.1
KEYWORDS collagenase; gelatinase; metalloprotease.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2733)
AUTHORS Collier,I.E., Wilhelm,S.M., Eisen,A.Z., Marmer,B.L., Grant,G.A.,
Seltzer,J.L., Kronberger,A., He,C.S., Bauer,E.A. and Goldberg,G.I.
TITLE H-ras oncogene-transformed human bronchial epithelial cells (TBE-1)
secrete a single metalloprotease capable of degrading basement
membrane collagen
JOURNAL J. Biol. Chem. 263 (14), 6579-6587 (1988)
PUBMED 2834383
COMMENT Original source text: Human (strain WUN) H-ras-transformed
bronchial epithelial cell line TBE-1, cDNA to mRNA.
Computer-readable sequence for [1] kindly provided by I.Collier,
07-MAR-1988.
FEATURES Location/Qualifiers
source 1..2733
/db_xref="H-InvDB:HIT000191140"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS <1..1936
/note="collagenase type IV precursor"
/codon_start=2
/protein_id="AAA35701.1"
/translation="LCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPK
WDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRW
EHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCK
FPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCK
FPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV
FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA
MGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTP
EICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVY
EAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYI
FAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKL
ENQSLKSVKFGSIKSDWLGC"
sig_peptide <1..40
/note="collagenase type IV signal peptide"
mat_peptide 41..1933
/product="collagenase type IV"
BASE COUNT 608 a 819 c 706 g 600 t
ORIGIN Unreported.
1 cctctgtctc ctgggctgcc tgctgagcca cgccgccgcc gcgccgtcgc ccatcatcaa
61 gttccccggc gatgtcgccc ccaaaacgga caaagagttg gcagtgcaat acctgaacac
121 cttctatggc tgccccaagg agagctgcaa cctgtttgtg ctgaaggaca cactaaagaa
181 gatgcagaag ttctttggac tgccccagac aggtgatctt gaccagaata ccatcgagac
241 catgcggaag ccacgctgcg gcaacccaga tgtggccaac tacaacttct tccctcgcaa
301 gcccaagtgg gacaagaacc agatcacata caggatcatc ggctacacac ctgatctgga
361 cccagagaca gtggatgatg cctttgctcg tgccttccaa gtctggagcg atgtgacccc
421 actgcggttt tctcgaatcc atgatggaga ggcagacatc atgatcaact ttggccgctg
481 ggagcatggc gatggatacc cctttgacgg taaggacgga ctcctggctc atgccttcgc
541 cccaggcact ggtgttgggg gagactccca ttttgatgac gatgagctat ggaccttggg
601 agaaggccaa gtggtccgtg tgaagtatgg gaacgccgat ggggagtact gcaagttccc
661 cttcttgttc aatggcaagg agtacaacag ctgcactgat actggccgca gcgatggctt
721 cctctggtgc tccaccacct acaactttga gaaggatggc aagtacggct tctgtcccca
781 tgaagccctg ttcaccatgg gcggcaacgc tgaaggacag ccctgcaagt ttccattccg
841 cttccagggc acatcctatg acagctgcac cactgagggc cgcacggatg gctaccgctg
901 gtgcggcacc actgaggact acgaccgcga caagaagtat ggcttctgcc ctgagaccgc
961 catgtccact gttggtggga actcagaagg tgccccctgt gtcttcccct tcactttcct
1021 gggcaacaaa tatgagagct gcaccagcgc cggccgcagt gacggaaaga tgtggtgtgc
1081 gaccacagcc aactacgatg acgaccgcaa gtggggcttc tgccctgacc aagggtacag
1141 cctgttcctc gtggcagccc acgagtttgg ccacgccatg gggctggagc actcccaaga
1201 ccctggggcc ctgatggcac ccatttacac ctacaccaag aacttccgtc tgtcccagga
1261 tgacatcaag ggcattcagg agctctatgg ggcctctcct gacattgacc ttggcaccgg
1321 ccccaccccc acactgggcc ctgtcactcc tgagatctgc aaacaggaca ttgtatttga
1381 tggcatcgct cagatccgtg gtgagatctt cttcttcaag gaccggttca tttggcggac
1441 tgtgacgcca cgtgacaagc ccatggggcc cctgctggtg gccacattct ggcctgagct
1501 cccggaaaag attgatgcgg tatacgaggc cccacaggag gagaaggctg tgttctttgc
1561 agggaatgaa tactggatct actcagccag caccttggag cgagggtacc ccaagccact
1621 gaccagcctg ggactgcccc ctgatgtcca gcgagtggat gccgccttta actggagcaa
1681 aaacaagaag acatacatct ttgctggaga caaattctgg agatacaatg aggtgaagaa
1741 gaaaatggat cctggcttcc ccaagctcat cgcagatgcc tggaatgcca tccccgataa
1801 cctggatgcc gtcgtggacc tgcagggcgg cggtcacagc tacttcttca agggtgccta
1861 ttacctgaag ctggagaacc aaagtctgaa gagcgtgaag tttggaagca tcaaatccga
1921 ctggctaggc tgctgagctg gccctggctc ccacaggccc ttcctctcca ctgccttcga
1981 tacaccgggc ctggagaact agagaaggac ccggaggggc ctggcagccg tgccttcagc
2041 tctacagcta atcagcattc tcactcctac ctggtaattt aagattccag agagtggctc
2101 ctcccggtgc ccaagaatag atgctgactg tactcctccc aggcgcccct tccccctcca
2161 atcccaccaa ccctcagagc cacccctaaa gagatacttt gatattttca acgcagccct
2221 gctttgggct gccctggtgc tgccacactt caggctcttc tcctttcaca accttctgtg
2281 gctcacagaa cccttggagc caatggagac tgtctcaaga gggcactggt ggcccgacag
2341 cctggcacag ggcagtggga cagggcatgg ccaggtggcc actccagacc cctggctttt
2401 cactgctggc tgccttagaa cctttcttac attagcagtt tgctttgtat gcactttgtt
2461 tttttctttg ggtcttgttt tttttttcca cttagaaatt gcatttcctg acagaaggac
2521 tcaggttgtc tgaagtcact gcacagtgca tctcagccca catagtgatg gttcccctgt
2581 tcactctact tagcatgtcc ctaccgagtc tcttctccac tggatggagg aaaaccaagc
2641 cgtggcttcc cgctcagccc tccctgcccc tcccttcaac cattccccat gggaaatgtc
2701 aacaagtatg aataaagaca cctactgagt ggc
//