LOCUS       HUMCBG                  1422 bp    mRNA    linear   HUM 08-AUG-1995
DEFINITION  Human corticosteroid binding globulin mRNA, complete cds.
ACCESSION   J02943
VERSION     J02943.1
KEYWORDS    corticosteroid binding globulin; plasma transport protein;
            transcortin.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1422)
  AUTHORS   Hammond,G.L., Smith,C.L., Goping,I.S., Underhill,D.A., Harley,M.J.,
            Reventos,J., Musto,N.A., Gunsalus,G.L. and Bardin,C.W.
  TITLE     Primary structure of human corticosteroid binding globulin, deduced
            from hepatic and pulmonary cDNAs, exhibits homology with serine
            protease inhibitors
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 84 (15), 5153-5157 (1987)
   PUBMED   3299377
COMMENT     Original source text: Homo sapiens liver and lung cDNA to mRNA.
            Draft entry and printed copy of sequence [1] kindly provided by
            G.L.Hammond, 01-JUL-1987.
FEATURES             Location/Qualifiers
     source          1..1422
                     /db_xref="H-InvDB:HIT000191105"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /map="14q31-q32.1"
                     /tissue_type="liver and lung"
     gene            1..1422
                     /gene="CBG"
     mRNA            <1..1422
                     /gene="CBG"
                     /product="CBG mRNA"
     CDS             36..1253
                     /gene="CBG"
                     /note="corticosteroid binding globulin precursor"
                     /codon_start=1
                     /protein_id="AAB59523.1"
                     /db_xref="GDB:G00-127-865"
                     /translation="MPLLLYTCLLWLPTSGLWTVQAMDPNAAYVNMSNHHRGLASANV
                     DFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSE
                     TEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNF
                     QDWATASRQINSYVKNKTQGKIVDLFSGLDSPAILVLVNYIFFKGTWTQPFDLASTRE
                     ENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTV
                     IAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRI
                     TQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFIIMIFDHFT
                     WSSLFLARVMNPV"
     sig_peptide     36..101
                     /gene="CBG"
                     /note="corticosteroid binding globulin signal peptide"
     mat_peptide     102..1250
                     /gene="CBG"
                     /product="corticosteroid binding globulin"
     variation       54
                     /gene="CBG"
                     /note="a in liver; g in lung"
                     /replace="g"
BASE COUNT          340 a          406 c          344 g          332 t
ORIGIN      18 bp upstream of HaeIII site.
        1 cagcctaccg cagactggcc tggctatact ggacaatgcc actcctcctg tacacctgtc
       61 ttctctggct gcccaccagc ggcctctgga ccgtccaggc catggatcct aacgctgctt
      121 atgtgaacat gagtaaccat caccggggcc tggcttcagc caacgttgac tttgccttca
      181 gcctgtataa gcacctagtg gccttgagtc ccaaaaagaa cattttcatc tcccctgtga
      241 gcatctccat ggccttagct atgctgtccc tgggcacctg tggccacaca cgggcccagc
      301 ttctccaggg cctgggtttc aacctcactg agaggtctga gactgagatc caccagggtt
      361 tccagcacct gcaccaactc tttgcaaagt cagacaccag cttagaaatg actatgggca
      421 atgccttgtt tcttgatggc agcctggagt tgctggagtc attctcagca gacatcaagc
      481 actactatga gtcagaggtc ttggctatga atttccagga ctgggcaaca gccagcagac
      541 agatcaacag ctatgtcaag aataagacac aggggaaaat tgtcgacttg ttttcagggc
      601 tggatagccc agccatcctc gtcctggtca actatatctt cttcaaaggc acatggacac
      661 agccctttga cctggcaagc accagggagg agaacttcta tgtggacgag acaactgtgg
      721 tgaaggtgcc catgatgttg cagtcgagca ccatcagtta ccttcatgac tcagagctcc
      781 cctgccagct ggtgcagatg aactacgtgg gcaatgggac tgtcttcttc atccttccgg
      841 acaaggggaa gatgaacaca gtcatcgctg cactgagccg ggacacgatt aacaggtggt
      901 ccgcaggcct gaccagcagc caggtggacc tgtacattcc aaaggtcacc atctctggag
      961 tctatgacct tggagatgtg ctggaggaaa tgggcattgc agacttgttc accaaccagg
     1021 caaatttctc acgcatcacc caggacgccc agctgaagtc atcaaaggtg gtccataaag
     1081 ctgtgctgca actcaatgag gagggtgtgg acacagctgg ctccactggg gtcaccctaa
     1141 acctgacgtc caagcctatc atcttgcgtt tcaaccagcc cttcatcatc atgatcttcg
     1201 accacttcac ctggagcagc cttttcctgg cgagggttat gaacccagtg taagagacca
     1261 cccacccaga gcctcagcac tgtctgactt tgggaaccag ggatcccaca gaaatgtttt
     1321 ggagagcggg aggtttcccc caatctcctc caagttcttc tccctccaac cagagttgtg
     1381 tctaacttta ggcatctttt aataaatgtc attgcgactc tg
//