LOCUS HUMFISP 1963 bp mRNA linear HUM 08-NOV-1994 DEFINITION Human factor I (C3b/C4b inactivator) mRNA, complete cds. ACCESSION J02770 VERSION J02770.1 KEYWORDS C3b/C34 inactivator; complement cascade; factor I; serine protease. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1963) AUTHORS Goldberger,G., Bruns,G.A., Rits,M., Edge,M.D. and Kwiatkowski,D.J. TITLE Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4 JOURNAL J. Biol. Chem. 262 (21), 10065-10071 (1987) PUBMED 2956252 COMMENT Original source text: Human hepatoma cell line HepG2 and normal liver, cDNA to mRNA, clones lambda-G2-HI1971 and lambda-gt10. Draft entry and printed copy of sequence [1] kindly provided by G.Goldberger, 11-MAY-1987. There were no sequence differences between the sequences from the hepatoma cell line and the normal liver. FEATURES Location/Qualifiers source 1..1963 /db_xref="H-InvDB:HIT000191087" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /map="4q24-q25" gene 1..1963 /gene="IF" mRNA <1..1963 /gene="IF" /product="SPRC mRNA" CDS 15..1766 /gene="IF" /note="prepro-C3b/C4B inactivator" /codon_start=1 /protein_id="AAA52455.1" /db_xref="GDB:G00-120-077" /translation="MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCD KVFCQPWQRCIEGTCVCKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLN NGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQ QGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQK ADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQY QCNGEVDCITGEDEVGCAGFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRMH IRRKRIVGGKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQI WTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSI PACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNCSKFYGNRFYEKEM ECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGFYTKVANYF DWISYHVGRPFISQYNV" sig_peptide 15..68 /gene="IF" /note="C3b/C4b inactivator signal peptide" mat_peptide 69..1019 /gene="IF" /product="C3b/C4b inactivator heavy chain" mat_peptide 1032..1763 /gene="IF" /product="C3b/C4b inactivator light chain" BASE COUNT 605 a 353 c 454 g 551 t ORIGIN Chromosome 4. 1 cgaacacctc caacatgaag cttcttcatg ttttcctgtt atttctgtgc ttccacttaa 61 ggttttgcaa ggtcacttat acatctcaag aggatctggt ggagaaaaag tgcttagcaa 121 aaaaatatac tcacctctcc tgcgataaag tcttctgcca gccatggcag agatgcattg 181 agggcacctg tgtttgtaaa ctaccgtatc agtgcccaaa gaatggcact gcagtgtgtg 241 caactaacag gagaagcttc ccaacatact gtcaacaaaa gagtttggaa tgtcttcatc 301 cagggacaaa gtttttaaat aacggaacat gcacagccga aggaaagttt agtgtttcct 361 tgaagcatgg aaatacagat tcagagggaa tagttgaagt aaaacttgtg gaccaagata 421 agacaatgtt catatgcaaa agcagctgga gcatgaggga agccaacgtg gcctgccttg 481 accttgggtt tcaacaaggt gctgatactc aaagaaggtt taagttgtct gatctctcta 541 taaattccac tgaatgtcta catgtgcatt gccgaggatt agagaccagt ttggctgaat 601 gtacttttac taagagaaga actatgggtt accaggattt cgctgatgtg gtttgttata 661 cacagaaagc agattctcca atggatgact tctttcagtg tgtgaatggg aaatacattt 721 ctcagatgaa agcctgtgat ggtatcaatg attgtggaga ccaaagtgat gaactgtgtt 781 gtaaagcatg ccaaggcaaa ggcttccatt gcaaatcggg tgtttgcatt ccaagccagt 841 atcaatgcaa tggtgaggtg gactgcatta caggggaaga tgaagttggc tgtgcaggct 901 ttgcatctgt ggctcaagaa gaaacagaaa ttttgactgc tgacatggat gcagaaagaa 961 gacggataaa atcattatta cctaaactat cttgtggagt taaaaacaga atgcacattc 1021 gaaggaaacg aattgtggga ggaaagcgag cacaactggg agacctccca tggcaggtgg 1081 caattaagga tgccagtgga atcacctgtg ggggaattta tattggtggc tgttggattc 1141 tgactgctgc acattgtctc agagccagta aaactcatcg ttaccaaata tggacaacag 1201 tagtagactg gatacacccc gaccttaaac gtatagtaat tgaatacgtg gatagaatta 1261 ttttccatga aaactacaat gcaggcactt accaaaatga catcgctttg attgaaatga 1321 aaaaagacgg aaacaaaaaa gattgtgagc tgcctcgttc catccctgcc tgtgtcccct 1381 ggtctcctta cctattccaa cctaatgata catgcatcgt ttctggctgg ggacgagaaa 1441 aagataacga aagagtcttt tcacttcagt ggggtgaagt taaactaata agcaactgct 1501 ctaagtttta cggaaatcgt ttctatgaaa aagaaatgga atgtgcaggt acatatgatg 1561 gttccatcga tgcctgtaaa ggggactctg gaggcccctt agtctgtatg gatgccaaca 1621 atgtgactta tgtctggggt gttgtgagtt ggggggaaaa ctgtggaaaa ccagagttcc 1681 caggttttta caccaaagtg gccaattatt ttgactggat tagctaccat gtaggaaggc 1741 cttttatttc tcagtacaat gtataaaatt gtgatctctc tcttcattct attctttttc 1801 tctcaagagt tccatttaat ggaaataaaa cggtataatt aataattctc taggggggaa 1861 aaatgaagca aatctcattg gatattttta aaggtctcca cagagtttat gccatattgg 1921 aattttgttg tataattctc aaataaatat tttggtgaag cat //