LOCUS HUMGP3A 3170 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human endothelial membrane glycoprotein IIIa (GPIIIa) mRNA,
complete cds.
ACCESSION J02703
VERSION J02703.1
KEYWORDS glycoprotein; glycoprotein IIIa.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3170)
AUTHORS Fitzgerald,L.A., Steiner,B., Rall,S.C. Jr., Lo,S.S. and
Phillips,D.R.
TITLE Protein sequence of endothelial glycoprotein IIIa derived from a
cDNA clone. Identity with platelet glycoprotein IIIa and similarity
to 'integrin'
JOURNAL J. Biol. Chem. 262 (9), 3936-3939 (1987)
PUBMED 3494014
COMMENT Original source text: Human umbilical vein endothelial cell, cDNA
to mRNA.
Draft entry and computer-readable sequence for [1] kindly provided
by L.A.Fitzgerald, 10-FEB-1987.
The endothelial membrane glycoprotein IIIa is probably identical to
the platelet glycoprotein IIIa.
FEATURES Location/Qualifiers
source 1..3170
/db_xref="H-InvDB:HIT000191082"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="17q21.32"
gene 1..3170
/gene="ITGB3"
CDS 21..2387
/gene="ITGB3"
/note="glycoprotein IIIa precursor"
/codon_start=1
/protein_id="AAA52589.1"
/db_xref="GDB:G00-120-013"
/translation="MRARPRPRPLWVTVLALGALAGVGVGGPNICTTRGVSSCQQCLA
VSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGD
SSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNL
GTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKH
VLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTT
DAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIF
AVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEEL
SLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDS
LIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQ
QDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHG
QCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTC
EKCPTCPDACTFKKECVECKKFDREPYMTENTCNRYCRDEIESVKELKDTGKDAVNCT
YKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLI
WKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT"
sig_peptide 21..98
/gene="ITGB3"
/note="glycoprotein IIIa signal peptide (putative);
putative"
mat_peptide 99..2384
/gene="ITGB3"
/product="glycoprotein IIIa"
BASE COUNT 705 a 809 c 909 g 747 t
ORIGIN 132 bp upstream of SacI site.
1 cgccgcggga ggcggacgag atgcgagcgc ggccgcggcc ccggccgctc tgggtgactg
61 tgctggcgct gggggcgctg gcgggcgttg gcgtaggagg gcccaacatc tgtaccacgc
121 gaggtgtgag ctcctgccag cagtgcctgg ctgtgagccc catgtgtgcc tggtgctctg
181 atgaggccct gcctctgggc tcacctcgct gtgacctgaa ggagaatctg ctgaaggata
241 actgtgcccc agaatccatc gagttcccag tgagtgaggc ccgagtacta gaggacaggc
301 ccctcagcga caagggctct ggagacagct cccaggtcac tcaagtcagt ccccagagga
361 ttgcactccg gctccggcca gatgattcga agaatttctc catccaagtg cggcaggtgg
421 aggattaccc tgtggacatc tactacttga tggacctgtc ttactccatg aaggatgatc
481 tgtggagcat ccagaacctg ggtaccaagc tggccaccca gatgcgaaag ctcaccagta
541 acctgcggat tggcttcggg gcatttgtgg acaagcctgt gtcaccatac atgtatatct
601 ccccaccaga ggccctcgaa aacccctgct atgatatgaa gaccacctgc ttgcccatgt
661 ttggctacaa acacgtgctg acgctaactg accaggtgac ccgcttcaat gaggaagtga
721 agaagcagag tgtgtcacgg aaccgagatg ccccagaggg tggctttgat gccatcatgc
781 aggctacagt ctgtgatgaa aagattggct ggaggaatga tgcatcccac ttgctggtgt
841 ttaccactga tgccaagact catatagcat tggacggaag gctggcaggc attgtccagc
901 ctaatgacgg gcagtgtcat gttggtagtg acaatcatta ctctgcctcc actaccatgg
961 attatccctc tttggggctg atgactgaga agctatccca gaaaaacatc aatttgatct
1021 ttgcagtgac tgaaaatgta gtcaatctct atcagaacta tagtgagctc atcccaggga
1081 ccacagttgg ggttctgtcc atggattcca gcaatgtcct ccagctcatt gttgatgctt
1141 atgggaaaat ccgttctaaa gtcgagctgg aagtgcgtga cctccctgaa gagttgtctc
1201 tatccttcaa tgccacctgc ctcaacaatg aggtcatccc tggcctcaag tcttgtatgg
1261 gactcaagat tggagacacg gtgagcttca gcattgaggc caaggtgcga ggctgtcccc
1321 aggagaagga gaagtccttt accataaagc ccgtgggctt caaggacagc ctgatcgtcc
1381 aggtcacctt tgattgtgac tgtgcctgcc aggcccaagc tgaacctaat agccatcgct
1441 gcaacaatgg caatgggacc tttgagtgtg gggtatgccg ttgtgggcct ggctggctgg
1501 gatcccagtg tgagtgctca gaggaggact atcgcccttc ccagcaggac gagtgcagcc
1561 cccgagaggg tcagcccgtc tgcagccagc ggggcgagtg cctctgtggt caatgtgtct
1621 gccacagcag tgactttggc aagatcacgg gcaagtactg cgagtgtgac gacttctcct
1681 gtgtccgcta caagggggag atgtgctcag gccatggcca gtgcagctgt ggggactgcc
1741 tgtgtgactc cgactggacc ggctactact gcaactgtac cacgcgtact gacacctgca
1801 tgtccagcaa tgggctgctg tgcagcggcc gcggcaagtg tgaatgtggc agctgtgtct
1861 gtatccagcc gggctcctat ggggacacct gtgagaagtg ccccacctgc ccagatgcct
1921 gcacctttaa gaaagaatgt gtggagtgta agaagtttga ccgggagccc tacatgaccg
1981 aaaatacctg caaccgttac tgccgtgacg agattgagtc agtgaaagag cttaaggaca
2041 ctggcaagga tgcagtgaat tgtacctata agaatgagga tgactgtgtc gtcagattcc
2101 agtactatga agattctagt ggaaagtcca tcctgtatgt ggtagaagag ccagagtgtc
2161 ccaagggccc tgacatcctg gtggtcctgc tctcagtgat gggggccatt ctgctcattg
2221 gccttgccgc cctgctcatc tggaaactcc tcatcaccat ccacgaccga aaagaattcg
2281 ctaaatttga ggaagaacgc gccagagcaa aatgggacac agccaacaac ccactgtata
2341 aagaggccac gtctaccttc accaatatca cgtaccgggg cacttaatga taagcagtca
2401 tcctcagatc attatcagcc tgtgccagga ttgcaggagt ccctgccatc atgtttacag
2461 aggacagtat ttgtggggag ggatttcggg gctcagagtg gggtaggttg ggagaatgtc
2521 agtatgtgga agtgtgggtc tgtgtgtgtg tatgtggggg tctgtgtgtt tatgtgtgtg
2581 tgttgtgtgt gggagtgtgt aatttaaaat tgtgatgtgt cctgataagc tgagctcctt
2641 agcctttgtc ccagaatgcc tcctgcaggg attcttcctg cttagcttga gggtgactat
2701 ggagctgagc aggtgttctt cattacctca gtgagaagcc agctttcctc atcaggccat
2761 tgtccctgaa gagaagggca gggctgaggc ctctcattcc agaggaaggg acaccaagcc
2821 ttggctctac cctgagttca taaatttatg gttctcaggc ctgactctca gcagctatgg
2881 taggaactgc tggcttggca gcccgggtca tctgtacctc tgcctccttt cccctccctc
2941 aggccgaagg aggagtcagg gagagctgaa ctattagagc tgcctgtgcc ttttgccatc
3001 ccctcaaccc agctatggtt ctctcgcaag ggaagtcctt gcaagctaat tctttgacct
3061 gttgggagtg aggatgtctg ggccactcag gggtcattca tggcctgggg gatgtaccag
3121 catctcccag ttcataatca caacccttca gatttgcctt attggcagcg
//