LOCUS HUMPAI2 1884 bp mRNA linear HUM 27-APR-1993
DEFINITION Human placental plasminogen activator inhibitor mRNA, complete cds.
ACCESSION J02685
VERSION J02685.1
KEYWORDS plasminogen activator inhibitor; serine protease inhibitor.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1884)
AUTHORS Ye,R.D., Wun,T.C. and Sadler,J.E.
TITLE cDNA cloning and expression in Escherichia coli of a plasminogen
activator inhibitor from human placenta
JOURNAL J. Biol. Chem. 262 (8), 3718-3725 (1987)
PUBMED 3029122
COMMENT Original source text: Human placenta, cDNA to mRNA, clone
lambda-PAI-75.1.
Draft entry and computer-readable sequence for [1] kindly provided
by R.D.Ye, 22-JAN-1987.
FEATURES Location/Qualifiers
source 1..1884
/db_xref="H-InvDB:HIT000191080"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
mRNA <1..1884
/product="PAI mRNA"
CDS 56..1303
/note="plasminogen activator inhibitor"
/codon_start=1
/protein_id="AAA36413.1"
/translation="MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYM
GSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADK
IHSSFRSLSSAINASTGDYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLE
CAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNG
LYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVS
TGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFN
KGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADH
PFLFLIMHKITKCILFFGRFCSP"
BASE COUNT 586 a 386 c 379 g 533 t
ORIGIN 355 bp upstream of PstI site.
1 gttacccgtc agacagcaac tcagagaata accagagaac aaccagattg aaacaatgga
61 ggatctttgt gtggcaaaca cactctttgc cctcaattta ttcaagcatc tggcaaaagc
121 aagccccacc cagaacctct tcctctcccc atggagcatc tcgtccacca tggccatggt
181 ctacatgggc tccaggggca gcaccgaaga ccagatggcc aaggtgcttc agtttaatga
241 agtgggagcc aatgcagtta cccccatgac tccagagaac tttaccagct gtgggttcat
301 gcagcagatc cagaagggta gttatcctga tgcgattttg caggcacaag ctgcagataa
361 aatccattca tccttccgct ctctcagctc tgcaatcaat gcatccacag gggattattt
421 actggaaagt gtcaataagc tgtttggtga gaagtctgcg agcttccggg aagaatatat
481 tcgactctgt cagaaatatt actcctcaga accccaggca gtagacttcc tagaatgtgc
541 agaagaagct agaaaaaaga ttaattcctg ggtcaagact caaaccaaag gcaaaatccc
601 aaacttgtta cctgaaggtt ctgtagatgg ggataccagg atggtcctgg tgaatgctgt
661 ctacttcaaa ggaaagtgga aaactccatt tgagaagaaa ctaaatgggc tttatccttt
721 ccgtgtaaac tcggctcagc gcacacctgt acagatgatg tacttgcgtg aaaagctaaa
781 cattggatac atagaagacc taaaggctca gattctagaa ctcccatatg ctggagatgt
841 tagcatgttc ttgttgcttc cagatgaaat tgccgatgtg tccactggct tggagctgct
901 ggaaagtgaa ataacctatg acaaactcaa caagtggacc agcaaagaca aaatggctga
961 agatgaagtt gaggtataca taccccagtt caaattagaa gagcattatg aactcagatc
1021 cattctgaga agcatgggca tggaggacgc cttcaacaag ggacgggcca atttctcagg
1081 gatgtcggag aggaatgacc tgtttctttc tgaagtgttc caccaagcca tggtggatgt
1141 gaatgaggag ggcactgaag cagccgctgg cacaggaggt gttatgacag ggagaactgg
1201 acatggaggc ccacagtttg tggcagatca tccgtttctt tttcttatta tgcataagat
1261 aaccaagtgc attttatttt tcggcagatt ttgctcaccc taaaactaag cgtgctgctt
1321 ctgcaaaaga tttttgtaga tgagctgtgt gcctcagaat tgctatttca aattgccaaa
1381 aatttagaga tgttttctac atatttctgc tcttctgaac aacttctgct acccactaaa
1441 taaaaacaca gaaataatta gacaattgtc tattataaca tgacaaccct attaatcatt
1501 tggtcttcta aaatgggatc atgcccattt agattttcct tactatcagt ttatttttat
1561 aacattaact tttactttgt tatttattat tttatataat ggtgagtttt taaattattg
1621 ctcactgcct atttaatgta gctaataaag ttatagaagc agatgatctg ttaatttcct
1681 atctaataaa tgcctttaat tgttctcata atgaagaata agtaggtatc cctccatgcc
1741 cttctataat aaatatctgg aaaaaacatt aaacaatagg caaatatatg ttatgtgcat
1801 ttctagaaat acataacaca tatatatgtc tgtatcttat attcaattgc aagtatataa
1861 taaataaacc tgcttccaaa caac
//