LOCUS HUMAPLA 2203 bp mRNA linear HUM 27-APR-1993
DEFINITION Human alpha-2-antiplasmin mRNA, 3' end.
ACCESSION J02654 J02653 M18029
VERSION J02654.1
KEYWORDS antiplasmin; serine protease.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2203)
AUTHORS Holmes,W.E., Nelles,L., Lijnen,H.R. and Collen,D.
TITLE Primary structure of human alpha 2-antiplasmin, a serine protease
inhibitor (serpin)
JOURNAL J. Biol. Chem. 262 (4), 1659-1664 (1987)
PUBMED 2433286
REFERENCE 2 (bases 1150 to 1257)
AUTHORS Holmes,W.E., Lijnen,H.R., Nelles,L., Kluft,C., Nieuwenhuis,H.K.,
Rijken,D.C. and Collen,D.
TITLE Alpha 2-antiplasmin Enschede: alanine insertion and abolition of
plasmin inhibitory activity
JOURNAL Science 238 (4824), 209-211 (1987)
PUBMED 2958938
COMMENT Original source text: Human liver, cDNA to mRNA, clones AP[1,73].
Draft entry and computer-readable copy of sequence in [1] kindly
provided by W.E.Holmes, 18-NOV-1986.
FEATURES Location/Qualifiers
source 1..2203
/db_xref="H-InvDB:HIT000191078"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
CDS <1..1467
/note="alpha-2-antiplasmin precursor"
/codon_start=1
/protein_id="AAA35543.1"
/translation="LWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPL
TLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPN
LILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLA
ARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLS
GLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFL
LEQPEIQVADFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLP
KLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAA
ATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGN
KDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK"
sig_peptide <1..108
/note="alpha-2-antiplasmin signal peptide"
mat_peptide 109..1464
/product="alpha-2-antiplasmin"
BASE COUNT 412 a 705 c 650 g 436 t
ORIGIN 87 bp upstream of HpaII site.
1 ctctgggggc tcctggtgct cagctggtcc tgcctgcaag gcccctgctc cgtgttctcc
61 cctgtgagcg ccatggagcc cttgggccgg cagctaacta gcgggccgaa ccaggagcag
121 gtgtccccac ttaccctcct caagttgggc aaccaggagc ctggtggcca gactgccctg
181 aagagtcccc caggagtctg cagcagagac cccaccccag agcagaccca caggctggcc
241 cgggccatga tggccttcac tgccgacctg ttctccctgg tggctcaaac gtccacctgc
301 cccaacctca tcctgtcacc cctgagtgtg gccctggcgc tgtctcacct ggcactaggt
361 gctcagaacc acacgttgca gaggctgcaa caggtgctgc acgcaggctc agggccctgc
421 ctcccccatc tgctgagccg cctctgccag gacctgggcc ccggcgcgtt ccgactggct
481 gccaggatgt acctgcagaa aggatttccc atcaaagaag atttcctgga acaatccgaa
541 cagctatttg gggcaaagcc cgtgagcctg acgggaaagc aggaagatga cctggcaaac
601 atcaaccaat gggtgaagga ggccacggag gggaagattc aggaattcct ctctgggctg
661 ccggaagaca ccgtgttgct tctcctcaac gccatccact tccagggttt ctggaggaac
721 aagtttgacc cgagccttac ccagagagac tccttccacc tggacgagca gttcacggtg
781 cccgtggaaa tgatgcaggc ccgcacgtac ccgctgcgct ggttcttgct ggagcagcct
841 gagatccagg tggctgattt cccctttaag aacaacatga gctttgtggt ccttgtaccc
901 acccactttg aatggaacgt gtcccaggta ctggccaacc tgagttggga caccctgcac
961 ccacctctgg tgtgggagag gcccaccaag gtccggctgc ctaagctgta tctgaaacac
1021 caaatggacc tggtggccac cctcagccag ctgggcctgc aggagttgtt ccaggcccca
1081 gacctgcgtg ggatctccga gcagagcctg gtggtgtccg gcgtgcagca tcagtccacc
1141 ctggagctca gcgaggtcgg cgtggaggcg gcggcggcca ccagcattgc catgtcccgc
1201 atgtccctgt cctccttcag cgtgaaccgc cccttcctct tcttcatctt cgaggacacc
1261 acaggccttc ccctcttcgt gggcagcgtg aggaacccca accccagtgc accgcgggag
1321 ctcaaggaac agcaggattc cccgggcaac aaggacttcc tccagagcct gaaaggcttc
1381 ccccgcggag acaagctttt cggccctgac ttaaaacttg tgccccccat ggaggaggat
1441 tacccccagt ttggcagccc caagtgaggg gccgtggctg tggcatccag agtccctgcc
1501 tggaccagcc tctccactca tgtgactctt tccaaccggc tttgtggcca ctggggcagg
1561 ggccgggggc agtctgagag aggccattct ttcccaacac ctcttgggga gtttgggtgg
1621 ggggggggcg cggctgggag gagggcaggc atcggggagc cgggagcctg accctcatct
1681 ttcttccaaa caggctcaga gggtgtcctg caccggggcc tgggcaggag ggaggtgctt
1741 ctagttctgc caggagacag gttagctgct ccccacgtca gctgggacac cccgactttt
1801 gtttaccaga gaaaaaggga gggggagagg gctgcctttg gacttgtccc gggacaccta
1861 ggctagggtg gggagagacg ggccctggtg gtggctcggg aggcgaagcg ttgtcctcag
1921 ccccgcgtgg aactcgtgtc tggcacagcc tggctgtggc ctaacctgcc gagagtccat
1981 cagcctccat cctaccccct gtgccttgtc acgccagact tcccacggct cctcgagatc
2041 ccaacactgc cagcatttcc cttccttcct ctcctgtctc cctcctctgc ccgggagctc
2101 aggaaccgag gcagggaagg atcccatgag ctccttaagg ctcttttgta aggtttttgt
2161 agtgattttt atgccacctg aataaagaat gaatgggcct ggc
//