LOCUS AH002841 2910 bp DNA linear HUM 10-JUN-2016
DEFINITION Homo sapiens chromosome 22 immunoglobulin lambda light chain C
region (IGLC1), immunoglobulin lambda light chain C2 region
(IGLC2), immunoglobulin lambda light chain VJ3 region (IGL@), and
immunoglobulin lambda light chain C3 region (IGLC3) genes, partial
cds; Ig lambda-chain C4-region (IGLC4) gene and Ig lambda-chain
C4-region (IGLC5) pseudogene, complete sequence; and immunoglobulin
lambda light chain J6 region (IGLV) and immunoglobulin lambda light
chain C6 region (IGLC6) genes, partial cds.
ACCESSION AH002841 J00252 J00253 J00254 J03009 J03010 J03011 M18337 M18338
VERSION AH002841.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2910)
AUTHORS Hieter,P.A., Hollis,G.F., Korsmeyer,S.J., Waldmann,T.A. and
Leder,P.
TITLE Clustered arrangement of immunoglobulin lambda constant region
genes in man
JOURNAL Nature 294 (5841), 536-540 (1981)
PUBMED 6273747
REFERENCE 2 (bases 907 to 1089; 1605 to 1910; 2011 to 2320; 2421 to 2489;
2590 to 2910)
AUTHORS Dariavach,P., Lefranc,G. and Lefranc,M.P.
TITLE Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda
chain and C lambda 4 and C lambda 5 are pseudogenes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84 (24), 9074-9078 (1987)
PUBMED 3122211
COMMENT On or before Jun 10, 2016 this sequence version replaced J00252.1,
J00253.1, M18337.1, J00254.1, J03009.1, J03010.1, M18338.1,
J03011.1, AH002841.1.
FEATURES Location/Qualifiers
source 1..2910
/organism="Homo sapiens"
/mol_type="genomic DNA"
/db_xref="taxon:9606"
/chromosome="22"
/map="22q11.1-q11.2"
/tissue_type="liver"
/dev_stage="fetus"
/germline
gene <1..>315
/gene="IGLC1"
CDS <1..315
/gene="IGLC1"
/codon_start=1
/product="immunoglobulin lambda light chain C region"
/protein_id="AAA59106.1"
/translation="PKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADG
SPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE
CS"
gap 316..415
/estimated_length=unknown
gene <416..>764
/gene="IGLC2"
intron <416..444
/gene="IGLC2"
/note="intron J-C; G00-120-691"
CDS <445..764
/gene="IGLC2"
/note="C2-region"
/codon_start=3
/product="immunoglobulin lambda light chain C2 region"
/protein_id="AAA59107.1"
/translation="QPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKAD
SSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT
ECS"
gap 807..906
/estimated_length=unknown
gene <907..>1089
/gene="IGL@"
CDS <907..>1089
/gene="IGL@"
/note="putative"
/codon_start=1
/product="immunoglobulin lambda light chain VJ3 region"
/protein_id="AAA59108.1"
/translation="LDQDRPSGIPERFSVSNSGNTANLTINRVEAGDEADFYCQVWDS
DSDQFVFGGGTKVTVLG"
gap 1090..1189
/estimated_length=unknown
gene <1190..>1504
/gene="IGLC3"
CDS <1190..1504
/gene="IGLC3"
/codon_start=1
/product="immunoglobulin lambda light chain C3 region"
/protein_id="AAA59109.1"
/translation="PKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADS
SPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTE
CS"
gap 1505..1604
/estimated_length=unknown
gene 1605..1910
/gene="IGLC4"
/note="Ig lambda-chain C4-region"
gap 1911..2010
/estimated_length=unknown
gene 2011..2320
/gene="IGLC5"
/note="Ig lambda-chain C4-region"
/pseudo
gap 2321..2420
/estimated_length=unknown
gene <2421..>2489
/gene="IGLV"
CDS <2451..>2489
/gene="IGLV"
/codon_start=1
/product="immunoglobulin lambda light chain J6 region"
/protein_id="AAA59110.1"
/translation="NVFGSGTKVTVLG"
gap 2490..2589
/estimated_length=unknown
gene <2590..>2910
/gene="IGLC6"
CDS <2590..2910
/gene="IGLC6"
/codon_start=1
/product="immunoglobulin lambda light chain C6 region"
/protein_id="AAA59111.1"
/translation="GQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVKVAWKA
DGSPVNTGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAP
AECS"
BASE COUNT 571 a 683 c 595 g 361 t
ORIGIN
1 cccaaggcca accccacggt cactctgttc ccgccctcct ctgaggagct ccaagccaac
61 aaggccacac tagtgtgtct gatcagtgac ttctacccgg gagctgtgac agtggcttgg
121 aaggcagatg gcagccccgt caaggcggga gtggagacga ccaaaccctc caaacagagc
181 aacaacaagt acgcggccag cagctacctg agcctgacgc ccgagcagtg gaagtcccac
241 agaagctaca gctgccaggt cacgcatgaa gggagcaccg tggagaagac agtggcccct
301 acagaatgtt catagnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnngagcc
421 ccctgcccct catccacccc gcaggtcagc ccaaggctgc cccctcggtc actctgttcc
481 cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc ataagtgact
541 tctacccggg agccgtgaca gtggcttgga aagcagatag cagccccgtc aaggcgggag
601 tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc agctatctga
661 gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc acgcatgaag
721 ggagcaccgt ggagaagaca gtggccccta cagaatgttc ataggttctc aaccctcacc
781 cccaccacgg gagactagag ctgcagnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
901 nnnnnnttgg atcaggaccg gccctcaggc atccctgagc gattctctgt ctccaactct
961 gggaacacgg ccaacctgac catcaacagg gtcgaagccg gagatgaggc cgacttttac
1021 tgtcaggtgt gggatagtga tagtgatcag tttgtgttcg gcggagggac caaggtgacc
1081 gtcctgggtn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc ccaaggctgc
1201 cccctcggtc actctgttcc caccctcctc tgaggagctt caagccaaca aggccacact
1261 ggtgtgtctc ataagtgact tctacccggg agccgtgaca gttgcctgga aggcagatag
1321 cagccccgtc aaggcggggg tggagaccac cacaccctcc aaacaaagca acaacaagta
1381 cgcggccagc agctacctga gcctgacgcc tgagcagtgg aagtcccaca aaagctacag
1441 ctgccaggtc acgcatgaag ggagcaccgt ggagaagaca gttgccccta cggaatgttc
1501 atagnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnggtcac tgagacacct
1621 tcatctcctc tgaccccaga ggcagggagc tccaagacaa ggccacaatg gtgtgtctca
1681 tgagtgactt ctacccgaga gccatgacag tggcctggaa gatagatggc atcaccatca
1741 cccagggtgt ggagaccacc acaccctcca aacagagcaa caagtatgcg gccagcagct
1801 acctaagact ggcacccgaa cagtggaagt cccacaaatc ctacagctgc caggtcacgc
1861 atgaaaggaa cactgtggag aagacagtgg cccctgcaga atgttcttag nnnnnnnnnn
1921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ggtccgctca aggccacccc cttggtcact
2041 ctgttcccgc cctcctctga ggagctccaa gccaacaagg ccatgctggt gtgtctcata
2101 aatgacttct acccaggagc catagaagga aaatggcacc ctagtcacca agggcataga
2161 gacaaccaca ccctccacac agagcaacaa caactatgcg gccagcagct acctgagcct
2221 ggcacccgaa cagtggaagt cccacagaag ctacagctgc caggtcacgc acaaagaaag
2281 taccatggag aagacaatgg cccatgcaga atgttcttag nnnnnnnnnn nnnnnnnnnn
2341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2401 nnnnnnnnnn nnnnnnnnnn gggtttgtgt gcagggttat atcacagtgt aatgtgttcg
2461 gcagtggcac caaggtgacc gtcctcggtn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2581 nnnnnnnnng gtcagcccaa ggctgcccca tcggtcactc tgttcccgcc ctcctctgag
2641 gagcttcaag ccaacaaggc cacactggtg tgcctgatca gtgacttcta cccgggagct
2701 gtgaaagtgg cctggaaggc agatggcagc cccgtcaaca cgggagtgga gaccaccaca
2761 ccctccaaac agagcaacaa caagtacgcg gccagcagct acctgagcct gacgcctgag
2821 cagtggaagt cccacagaag ctacagctgc caggtcacgc atgaagggag caccgtggag
2881 aagacagtgg cccctgcaga atgttcatag
//