LOCUS AH007035 9375 bp DNA linear HUM 10-JUN-2016 DEFINITION Homo sapiens clone cosmid Ig13 immunoglobulin gamma-3 heavy chain constant region (IGHG3) and immunoglobulin gamma-1 heavy chain constant region (IGHG1) genes, partial cds; epsilon-1 pseudogene (IGHEP1) pseudogene, partial sequence; and immunoglobulin alpha-1 heavy chain constant region (IGHA1) gene, partial cds. ACCESSION AH007035 J00220 J00223 J00224 J00228 K01312 K01313 K01314 K01315 VERSION AH007035.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 9375) AUTHORS Takahashi,N., Ueda,S., Obata,M., Nikaido,T., Nakai,S. and Honjo,T. TITLE Structure of human immunoglobulin gamma genes: implications for evolution of a gene family JOURNAL Cell 29 (2), 671-679 (1982) PUBMED 6811139 COMMENT On or before Jun 10, 2016 this sequence version replaced K01312.1, K01313.1, K01314.1, J00228.1, K01315.1, J00224.1, J00223.1, J00220.1, AH007035.1. FEATURES Location/Qualifiers source 1..9375 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="14" /map="14q32.33" /clone="cosmid Ig13; Ig-gamma3-122" /tissue_type="placenta; liver" /germline gene <1..>1643 /gene="IGHG3" misc_feature 1..200 /gene="IGHG3" /note="5' flanking region" gap 201..300 /estimated_length=unknown CDS join(<301..335,726..776,920..964,1108..1152,1296..1340, 1459..>1508) /gene="IGHG3" /codon_start=2 /product="immunoglobulin gamma-3 heavy chain constant region" /protein_id="AAC82525.1" /translation="KPSNTKVDKRVELKTPLGDTTHTCPRCPEPKSCDTPPPCPRCPE PKSCDTPPPCPRCPEPKSCDTPPPCPRCPAPELLGGPSVFLFPPKP" exon <301..335 /gene="IGHG3" /number=1 exon 726..776 /gene="IGHG3" /number=2 exon 920..964 /gene="IGHG3" /number=3 exon 1108..1152 /gene="IGHG3" /number=4 exon 1296..1340 /gene="IGHG3" /number=5 exon 1459..>1508 /gene="IGHG3" /number=6 gap 1509..1608 /estimated_length=unknown CDS <1609..>1643 /gene="IGHG3" /note="CH3 domain" /codon_start=3 /product="immunoglobulin gamma-3 heavy chain constant region" /protein_id="AAC82526.1" /translation="NNYNTTPPMLD" gap 1644..1743 /estimated_length=unknown gene <1744..>3546 /gene="IGHG1" intron <1744..1952 /gene="IGHG1" CDS join(<1953..2246,2635..2679,2798..3127,3224..3546) /gene="IGHG1" /codon_start=3 /product="immunoglobulin gamma-1 heavy chain constant region" /protein_id="AAC82527.1" /translation="STKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC DKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWY VDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTI SKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTT PPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK" misc_difference 2306 /gene="IGHG1" /replace="" misc_difference 2336 /gene="IGHG1" /replace="" misc_difference 2357 /gene="IGHG1" /replace="" misc_difference 2376 /gene="IGHG1" /replace="" misc_difference 2386 /gene="IGHG1" /replace="" misc_difference 2397 /gene="IGHG1" /replace="" misc_difference 2427 /gene="IGHG1" /replace="" misc_difference 2435 /gene="IGHG1" /replace="" misc_difference 2508..2509 /gene="IGHG1" /replace="" misc_difference 3218 /gene="IGHG1" /replace="" misc_difference 3321 /gene="IGHG1" /replace="" gap 3753..3852 /estimated_length=unknown gene <3853..>6199 /gene="IGHEP1" /pseudo misc_feature 3853..4589 /gene="IGHEP1" /note="5' flanking region" /pseudo gap 4590..4689 /estimated_length=unknown misc_feature 4690..4919 /gene="IGHEP1" /note="5' flanking region" /pseudo gap 4920..5019 /estimated_length=unknown intron 5020..5462 /gene="IGHEP1" /note="A" /pseudo CDS join(<5463..5784,5868..>6199) /gene="IGHEP1" /note="epsilon-1 pseudogene; CH3 and CH4 regions" /pseudo /codon_start=1 exon 5463..5784 /gene="IGHEP1" /note="putative" /number=3 /pseudo intron 5785..5867 /gene="IGHEP1" /note="B" /pseudo exon 5868..6199 /gene="IGHEP1" /note="putative" /number=4 /pseudo gap 6743..6842 /estimated_length=unknown intron <6843..6983 /note="alpha-1 intron J-C" gene <6984..>8480 /gene="IGHA1" CDS join(<6984..7289,7504..7863,8086..8480) /gene="IGHA1" /codon_start=3 /product="immunoglobulin alpha-1 heavy chain constant region" /protein_id="AAC82528.1" /translation="SPTSPKVFPLSLCSTQPDGNVVIACLVQGFFPQEPLSVTWSESG QGVTARNFPPSQDASGDLYTTSSQLTLPATQCLAGKSVTCHVKHYTNPSQDVTVPCPV PSTPPTPSPSTPPTPSPSCCHPRLSLHRPALEDLLLGSEANLTCTLTGLRDASGVTFT WTPSSGKSAVQGPPERDLCGCYSVSSVLPGCAEPWNHGKTFTCTAAYPESKTPLTATL SKSGNTFRPEVHLLPPPSEELALNELVTLTCLARGFSPKDVLVRWLQGSQELPREKYL TWASRQEPSQGTTTFAVTSILRVAAEDWKKGDTFSCMVGHEALPLAFTQKTIDRLAGK PTHVNVSVVMAEVDGTCY" exon 6984..7289 /gene="IGHA1" intron 7290..7503 /gene="IGHA1" /note="A" exon 7504..7863 /gene="IGHA1" intron 7864..8085 /gene="IGHA1" /note="B" exon 8086..>8480 /gene="IGHA1" BASE COUNT 1798 a 2810 c 2535 g 1469 t ORIGIN 1 tttctggggc aggccaggcc tgacttggct gggggcaggg agggggctaa ggtgacgcag 61 gtggcgccag ccagggcgac acccaatgcc cgtgagccca gacactggac cctgcttgga 121 ccctcgtgga cagacaagaa ccgaggggcc tctgcgccct gggcccagct ctgtcccaca 181 ccgcagtcac atggcgccat nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 301 caagcccagc aacaccaagg tggacaagag agttggtgag aggccagcgc agggagggag 361 ggtgtctact ggaagccagc tcagccctcc tgcctggacg catcccggct gtgcagtccc 421 agcccagggc accaaggcag gccccgtctg actcctcacc cggaggcctc tgcccgcccc 481 actcatgctc agggagaggg tcttctggct ttttccacca ggctccaggc aggcacaggc 541 tgggtgcccc taccccaggc ccttcacaca caggggcagg tgctgcgctc agacgtgcca 601 gagccatatc caggaggacc ctgcccctga cctaagccca ccccaaaggc caaactctct 661 actcactcag ctcagacacc ttctctcttc ccagatctga gtaactccca atcttctctc 721 tgcagagctc aaaaccccac ttggtgacac aactcacaca tgcccacggt gcccaggtaa 781 gccagcccag gcctcgccct ccagctcaag gcgggacaag agccctagag tggcctgagt 841 ccagggacag gccccagcag ggtgctgacg catccacctc catcccagat ccccgtaact 901 cccaatcttc tctctgcaga gcctaaatct tgtgacacac ctcccccgtg cccacggtgc 961 ccaggtaagc cagcccaggc ctcgccctcc agctcaaggc aggacaggtg ccctagagtg 1021 gcctgagtcc agggacaggc cccagcaggg tgctgacgca tccacctcca tcccagatcc 1081 ccgtaactcc caatcttctc tctgcagagc ctaaatcttg tgacacacct cccccgtgcc 1141 cacggtgccc aggtaagcca gcccaggcct cgccctccag ctcaaggcag gacaggtgcc 1201 ctagagtggc ctgagtccag ggacaggccc cagcagggtg ctgacgcatc cacctccatc 1261 ccagatcccc gtaactccca atcttctctc tgcagagccc aaatcttgtg acacacctcc 1321 cccgtgccca aggtgcccag gtaagccagc ccaggcctcg ccctccagct caaggcagga 1381 caggtgccct agagtggcct gcatccaggg acaggtccca gtcgggtgct gacacatctg 1441 cctccatctc ttcctcagca cctgaactcc tgggaggacc gtcagtcttc ctcttccccc 1501 ctaaacccnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnag aacaactaca 1621 acaccacgcc tcccatgctg gacnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 1741 nnnagctttc tggggcaggc caggcctgac cttggctttg gggcagggag ggggctaagg 1801 tgaggcaggt ggcgccagca ggtgcacacc caatgcccat gagcccagac actggacgct 1861 gaacctcgcg gacagttaag aacccagggg cctctgcgcc tgggcccagc tctgtcccac 1921 accgcggtca catggcacca cctctcttgc agcctccacc aagggcccat cggtcttccc 1981 cctggcaccc tcctccaaga gcacctctgg gggcacagcg gccctgggct gcctggtcaa 2041 ggactacttc cccgaaccgg tgacggtgtc gtggaactca ggcgccctga ccagcggcgt 2101 gcacaccttc ccggctgtcc tacagtcctc aggactctac tccctcagca gcgtggtgac 2161 cgtgccctcc agcagcttgg gcacccagac ctacatctgc aacgtgaatc acaagcccag 2221 caacaccaag gtggacaaga aagttggtga gaggccagca cagggaggga gggtgtctgc 2281 tggaagcagg ctcagcgctc ctgcctggac gcatcccggc tatgcagccc cagtccaggg 2341 cagcaaggca ggccccgtct gcctcttcac ccggagcctc tgcccgcccc actcatgctc 2401 agggagaggg tcttctggct ttttcccagg ctctgggcag gcacaggcta ggtgccccta 2461 acccaggccc tgcacacaaa ggggcaggtg ctgggctcag acctgccaag agccatatcc 2521 gggaggaccc tgcccctgac ctaagcccac cccaaaggcc aaactctcca ctccctcagc 2581 tcggacacct tctctcctcc cagattccag taactcccaa tcttctctct gcagagccca 2641 aatcttgtga caaaactcac acatgcccac cgtgcccagg taagccagcc caggcctcgc 2701 cctccagctc aaggcgggac aggtgcccta gagtagcctg catccaggga caggccccag 2761 ccgggtgctg acacgtccac ctccatctct tcctcagcac ctgaactcct ggggggaccg 2821 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 2881 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 2941 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 3001 acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 3061 tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 3121 gccaaaggtg ggacccgtgg ggtgcgaggg ccacatggac agaggccggc tcggcccacc 3181 ctctgccctg agagtgaccg ctgtaccaac ctctgtccta cagggcagcc ccgagaacca 3241 caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc 3301 tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag 3361 ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 3421 tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 3481 gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 3541 aaatgagtgc gacggccggc aagccccgct ccccgggctc tcgcggtcgc acgaggatgc 3601 ttggcacgta ccccctgtac atacttcccg ggcgcccagc atggaaataa agcacccagc 3661 gctgccctgg gcccctgcga gactgtgatg gttctttcca cgggtcaggc cgagtctgag 3721 gcctgagtgg catgagggag gcagagcggg tcnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 3841 nnnnnnnnnn nngcttccac attttcaggt atctttatag caatgttcca ctcctcaata 3901 tcaatgttct gtgttagttt gtgttactag aaaaaaaaat acatgaggct agtaatttat 3961 aaagaaaagg tgtttaggcc aggcactgtg gctcatacct gtcatcctag cattttggga 4021 ggcagaagca ggaggatcac ttgagctcag aagtttgaga ccagcctagg caacatagtg 4081 agaacttgtc ttgaaaaaga caagaagaag ggaagggcgg gggagagcag aagagcagaa 4141 gggaaacacg gccctggcat ctgcttctgg tgaggcctca gggagattgc aatcatggca 4201 gaaggcgaag ggggagcagg catgtcacat ggcaagaggg agcaagagaa aagaagtggc 4261 acgtcccaga attgtattca acgggctgtc tctgggacta actgagggag aactcatcac 4321 ctgggagatg gtgctaggcc attcatgagg ggtccngccc catgatctaa tcacctccca 4381 ccaggcccac ctgcaacact ggggcctgag agagaagaga acctccccca gcactcggtg 4441 tgcatcggta gtgaaggagc ctcacctgag cccccgctgt tgctcaatcg aattcccaag 4501 aacagagaga aaagggaact atgccagggt ggcccgggcc tccaggggtt cccactccat 4561 ttttagctga aagcactgag gcagagctcn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4681 nnnnnnnnnt cactgcgcaa ctggctgatc ttggcaagtc cgagctgggt ggactgaggg 4741 gggcttggct gagtggacta gactgagacg ggctaacaga ctgacctgag gcgtagctgg 4801 gtgggctgag agggcaccct gtcccttaga ggacagcnnn ccaagctggg nnnnnnnnnn 4861 nnnnnnnnnn nnnnnnnnnn nnnnnnnagc tgagttgagt cagtggactg ggtaaagggn 4921 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 4981 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnc ttggataaat gggttactcg 5041 gtggactatc cgggctgaag gagannaagc tggggtatta cctgctggct tccctgacct 5101 ggcctgagtt cagcaggntg cgctgagctg gacnnnnnnn nnnnnnnnnn naagcttagc 5161 tggttgggct gagtaagctg ggctgagcta tttgggattg agctgaggag ggctaggctg 5221 ggggagagac ctgacgacgg acagggttaa aagctggagt gagcaggcct taaattattg 5281 aactaaattg ggctggggtg atctgaattt agctgggatg agctgggctg ggctgaactg 5341 tgcccacgtg aactgggcta aactaggctc gcctgagtgg actcagctgg gttggtctca 5401 actgggttca gctgagctgg gctcggctag actacactgg gttcagctga cactacactg 5461 ggttcaaccc aagaggggtg agcgcctacc taagccggcc cagcccgttc gacctgttca 5521 tccgcaagtc gcccacgatc acctgtctgg tggtggacct ggcacccagc aagtggaccg 5581 tgaacctgac ctggtcccgg gccagtggga agcctgtgaa ccactccacc agaaaggagg 5641 agaagcagcg caatggcacg ttaaccgtca cgtccaccgt gccggtgggc acccgagact 5701 ggatcgaagg ggagacctac cagtgcaggg tgacccaccc ccaactgccc agggccctcg 5761 tgcggtccac gaccaagacc agcggtgagc cacgggcagg ccggggtcgt ggggggaggg 5821 agggagcgag tgagcggggc ctgggctgac cccacgtctg gccacaggcc cgcgtgctgc 5881 cccggaagtc tatgcgtttg cgacgccgga gtggctgggg agccgggaca agcgcaccct 5941 cacctgcctg atccagaact tcatgcctga ggacatctcg gtgcagtggc tgcacaacga 6001 ggtgcagctc ccggacgccc ggcacagcac gacgcagccc cgcaagacca agggctccgg 6061 cttcttcatc ttcagccgcc tggaggtgac cagggccgag tgggagcaga aagatgagtt 6121 catctgccgt gcagtccatg aggcagcgat cccctcacag accgtccagc gagcggtatc 6181 tgtaaatccc ggtaaatgac gtactcctgc ctccctccct cccagggcta cgtccaggtg 6241 tgcagtgggg agggctggcc agaccttctg tccactgttg caacgacccc aggaagctac 6301 ccccaataaa cagtgcctgc tcagagccca gggtacaccc gttcttggga gcgggcaggg 6361 ctgtgggcag gtgcatcttg gcacagagga atgggccccc caggaggggc agtgggagga 6421 ggtgggcagg gctgagtccc cccaggagag gtggtgggag gaggtgggca gggctgaggt 6481 gccactcatc catctgcctt cgtgtcaggg ttatttgtca aacagcgtat ctgcagngac 6541 tcatcacagc taccccgggc cctctctgcc cccactctcg gtctaccccc tccaaggagt 6601 ccaaagaccc aggggaggtc ctcagggaag gggcaaggga gccccgacag ccctctctct 6661 tgggggcttg gcttctaccc ccaggtatag atgggcacac aggcctctcc aggtagaaaa 6721 acacccctaa ctgaaacccc ccnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 6841 nnggtccaac tgcaggcctg tggtgcagga gctgtgtgac catggggctg tcaccaggcc 6901 tctctgtgct gggttcctcc agtatagagg agaggcagta tagaggagag ggccgcgtcc 6961 tcacagtgca ttctgtgttc cagcatcccc gaccagcccc aaggtcttcc cgctgagcct 7021 ctgcagcacc cagccagatg ggaacgtggt catcgcctgc ctggtccagg gcttcttccc 7081 ccaggagcca ctcagtgtga cctggagcga aagcggacag ggcgtgaccg ccagaaactt 7141 cccacccagc caggatgcct ccggggacct gtacaccacg agcagccagc tgaccctgcc 7201 ggccacacag tgcctagccg gcaagtccgt gacatgccac gtgaagcact acacgaatcc 7261 cagccaggat gtgactgtgc cctgcccagg tcagagggca ggctggggag tggggcgggg 7321 ccaccccgtc gtgccctgac actgcgcctg cacccgtgtt ccccacaggg agccgcccct 7381 tcactcacac cagagtggac cccgggccga gccccaggag gtggtggtgg acaggccagg 7441 aggggcgagg cgggggcatg gggaagtatg tgctgaccag ctcaggccat ctctccactc 7501 cagttccctc aactccacct accccatctc cctcaactcc acctacccca tctccctcat 7561 gctgccaccc ccgactgtca ctgcaccgac cggccctcga ggacctgctc ttaggttcag 7621 aagcgaacct cacgtgcaca ctgaccggcc tgagagatgc ctcaggtgtc accttcacct 7681 ggacgccctc aagtgggaag agcgctgttc aaggaccacc tgagcgtgac ctctgtggct 7741 gctacagcgt gtccagtgtc ctgccgggct gtgccgagcc atggaaccat gggaagacct 7801 tcacttgcac tgctgcctac cccgagtcca agaccccgct aaccgccacc ctctcaaaat 7861 ccggtgggtc cagaccctgc tcggggccct gctcagtgct ctggtttgca aagcatattc 7921 ctggcctgcc tcctccctcc caatcctggg ctccagtgct catgccaagt acacagggaa 7981 actgaggcag gctgaggggc caggacacag cccggggtgc ccaccagagc agaggggctc 8041 tctcatcccc tgcccagccc cctgacctgg ctctctaccc tccaggaaac acattccggc 8101 ccgaggtcca cctgctgccg ccgccgtcgg aggagctggc cctgaacgag ctggtgacgc 8161 tgacgtgcct ggcacgcggc ttcagcccca aggacgtgct ggttcgctgg ctgcaggggt 8221 cacaggagct gccccgcgag aagtacctga cttgggcatc ccggcaggag cccagccagg 8281 gcaccaccac cttcgctgtg accagcatac tgcgcgtggc agccgaggac tggaagaagg 8341 gggacacctt ctcctgcatg gtgggccacg aggccctgcc gctggccttc acacagaaga 8401 ccatcgaccg cttggcgggt aaacccaccc atgtcaatgt gtctgttgtc atggcggagg 8461 tggacggcac ctgctactga gccgcccgcc tgtccccacc cctgaataaa ctccatgctc 8521 ccccaagcag ccccacgctt ccatccggcg cctgtctgtc catcctcagg gtctcagcac 8581 ttgggaaagg gccagggcat ggacagggaa gaataccccc tgccctgagc ctcggggggc 8641 ccctggcacc cccatgagac tttccaccct ggtgtgagtg tgagttgtga gtgtgagagt 8701 gtgtggtgca ggaggcctcg ctggtgtgag atcttaggtc tgccaaggca ggcacagccc 8761 aggatgggtt ctgagagacg cacatgcccc ggacagttct gagtgagcag tggcatggcc 8821 gtttgtccct gagagagccg cctctggctg tagctgggag ggaataggga gggtaaaagg 8881 agcaggctag ccaagaaagg cgcaggtagt ggcaggagcg gcgagggagt gaggggctgg 8941 actccagggc cccactggga ggacaagctc caggagggcc ccaccaccct agtgggtggg 9001 cctcaggacg tcccactgac gcatgcagga aggggcacct ccccttaacc acactgctct 9061 gtacggggca cgtgggcaca ggtgcacact cacactcaca tatatgcctg agccctgcag 9121 gagcggaacg ttcacagccc agacccagtt ccagaaaagc caggggagtc ccctcccaag 9181 cccccaagct cagcctgctc ccctaggccc ctctggcttc cctgtgtttc cactgtgcac 9241 agatcaggca ccaactccac agacccctcc caggcagccc ctgctccctg cctggccaag 9301 tctcccatcc cttcctaagc ccaactagga cccaaagcat agacagggag gggccacgtg 9361 gggtggcatc agaag //