LOCUS HUMFBRAA 2223 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human fibrinogen A-alpha-chain mRNA, complete cds.
ACCESSION J00128
VERSION J00128.1
KEYWORDS fibrin; fibrinogen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2223)
AUTHORS Kant,J.A., Lord,S.T. and Crabtree,G.R.
TITLE Partial mRNA sequences for human A alpha, B beta, and gamma
fibrinogen chains: evolutionary and functional implications
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80 (13), 3953-3957 (1983)
PUBMED 6575389
COMMENT Original source text: Human: liver DNA and cDNA to mRNA.
An alternate signal peptide start is found at bases 64-66, a
consensus polyadenylation signal is found at bases 2180-2185.
FEATURES Location/Qualifiers
source 1..2223
/db_xref="H-InvDB:HIT000191045"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q28"
gene 1..2223
/gene="FGA"
mRNA <1..2223
/gene="FGA"
/product="A-af mRNA"
CDS 55..1989
/gene="FGA"
/note="A-alpha fibrinogen"
/codon_start=1
/protein_id="AAA52427.1"
/db_xref="GDB:G00-119-129"
/translation="MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQ
SACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDS
HSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVR
AQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDR
QHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTS
YGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSW
NSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGS
FRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVT
SGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDG
FRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPG
IAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHA
KSRPVRGIHTSPLGKPSLSP"
sig_peptide 55..111
/gene="FGA"
/note="A-alpha fibrinogen signal peptide"
mat_peptide 112..1941
/gene="FGA"
/product="A-alpha fibrinogen mature peptide"
repeat_region 920..1231
/gene="FGA"
/note="A-af 39-bp tandem repeat unit"
BASE COUNT 648 a 494 c 553 g 528 t
ORIGIN Chromosome 4q31.
1 aatcctttct ttcagctgga gtgtcctcag gagccagccc cacccttaga aaagatgttt
61 tccatgagga tcgtctgcct ggtcctaagt gtggtgggca cagcatggac tgcagatagt
121 ggtgaaggtg actttctagc tgaaggagga ggcgtgcgtg gcccaagggt tgtggaaaga
181 catcaatctg cctgcaaaga ttcagactgg cccttctgct ctgatgaaga ctggaactac
241 aaatgccctt ctggctgcag gatgaaaggg ttgattgatg aagtcaatca agattttaca
301 aacagaataa ataagctcaa aaattcacta tttgaatatc agaagaacaa taaggattct
361 cattcgttga ccactaatat aatggaaatt ttgagaggcg atttttcctc agccaataac
421 cgtgataata cctacaaccg agtgtcagag gatctgagaa gcagaattga agtcctgaag
481 cgcaaagtca tagaaaaagt acagcatatc cagcttctgc aaaaaaatgt tagagctcag
541 ttggttgata tgaaacgact ggaggtggac attgatatta agatccgatc ttgtcgaggg
601 tcatgcagta gggctttagc tcgtgaagta gatctgaagg actatgaaga tcagcagaag
661 caacttgaac aggtcattgc caaagactta cttccctcta gagataggca acacttacca
721 ctgatcaaaa tgaaaccagt tccagacttg gttcccggaa attttaagag ccagcttcag
781 aaggtacccc cagagtggaa ggcattaaca gacatgccgc agatgagaat ggagttagag
841 agacctggtg gaaatgagat tactcgagga ggctccactt cttatggaac cggatcagag
901 acggaaagcc caaggaaccc tagcagtgct ggaagctgga actctgggag ctctggacct
961 ggaagtactg gaaaccgaaa ccctgggagc tctgggactg gagggactgc aacctggaaa
1021 cctggaagct ctggacctgg aagtactgga agctggaact ctgggagctc tggaactgga
1081 agtactggaa accaaaaccc tgggagccct agacctggta gtaccggaac ctggaatcct
1141 ggcagctctg aacgcggaag tgctggacac tggacttctg agagctctgt atctggtagt
1201 actggacaat ggcactctga atctggaagt tttaggccag atagcccagg ctctgggaac
1261 gcgaggccta acaacccaga ctggggcaca tttgaagagg tgtcaggaaa tgtaagtcca
1321 gggacaagga gagagtacca cacagaaaaa ctggtcactt ctaaaggaga taaagagctc
1381 aggactggta aagagaaggt cacctctggt agcacaacca ccacgcgtcg ttcatgctct
1441 aaaaccgtta ctaagactgt tattggtcct gatggtcaca aagaagttac caaagaagtg
1501 gtgacctccg aagatggttc tgactgtccc gaggcaatgg atttaggcac attgtctggc
1561 ataggcaccc tggatgggtt ccgccatagg caccctgatg aagctgcctt cttcgacact
1621 gcctcaactg gaaaaacatt cccaggtttc ttctcaccta tgttaggaga gtttgtcagt
1681 gagactgagt ctaggggctc agaatctggc atcttcacaa atacaaagga atccagttct
1741 catcaccctg ggatagctga attcccttcc cgtggtaaat cttcaagtta cagcaaacaa
1801 tttactagta gcacgagtta caacagagga gactccacat ttgaaagcaa gagctataaa
1861 atggcagatg aggccggaag tgaagccgat catgaaggaa cacatagcac caagagaggc
1921 catgctaaat ctcgccctgt cagaggtatc cacacttctc ctttggggaa gccttccctg
1981 tccccctaga ctaagttaaa tatttctgca cagtgttccc atggcccctt gcatttcctt
2041 cttaactctc tgttacacgt cattgaaact acactttttt ggtctgtttt tgtgctagac
2101 tgtaagttcc ttgggggcag ggcctttgtc tgtctcatct ctgtattccc aaatgcctaa
2161 cagtacaggc ccatgactca ataaatacat gttaaatgga tgaatgaatt cctctgaaac
2221 tct
//