LOCUS HUMFBRA 2182 bp mRNA linear HUM 08-NOV-1994
DEFINITION Human fibrinogen alpha-chain mRNA, complete cds.
ACCESSION J00127
VERSION J00127.1
KEYWORDS alpha-fibrinogen; fibrin; fibrinogen.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2182)
AUTHORS Rixon,M.W., Chan,W.Y., Davie,E.W. and Chung,D.W.
TITLE Characterization of a complementary deoxyribonucleic acid coding
for the alpha chain of human fibrinogen
JOURNAL Biochemistry 22 (13), 3237-3244 (1983)
PUBMED 6688355
COMMENT Original source text: Human liver, cDNA to mRNA (library of Chandra
and Woo), clone pHI-alpha-3.
The initiation codon 'atg' at positions 40-42 could also initiate
the translation of alpha-fibrinogen.
FEATURES Location/Qualifiers
source 1..2182
/db_xref="H-InvDB:HIT000191044"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/map="4q28"
gene 1..2182
/gene="FGA"
mRNA <1..2182
/gene="FGA"
/product="a-fibrinogen mRNA"
CDS 31..1965
/gene="FGA"
/note="alpha-fibrinogen precursor"
/codon_start=1
/protein_id="AAA52426.1"
/db_xref="GDB:G00-119-129"
/translation="MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQ
SACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDS
HSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVR
AQLVDMKRLEVDIDIKIRSCRGSWSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDR
QHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTS
YGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSAGSW
NSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGS
FRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVT
SGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDG
FRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPG
IAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHA
KSRPVRGIHTSPLGKPSLSP"
sig_peptide 31..87
/gene="FGA"
/note="alpha-fibrinogen signal peptide"
mat_peptide 88..1962
/gene="FGA"
/product="alpha-fibrinogen"
BASE COUNT 638 a 476 c 552 g 516 t
ORIGIN 90 bp upstream of PstI site; chromosome 4q31.
1 gtctaggagc cagccccacc cttagaaaag atgttttcca tgaggatcgt ctgcctagtt
61 ctaagtgtgg tgggcacagc atggactgca gatagtggtg aaggtgactt tctagctgaa
121 ggaggaggcg tgcgtggccc aagggttgtg gaaagacatc aatctgcctg caaagattca
181 gactggccct tctgctctga tgaagactgg aactacaaat gcccttctgg ctgcaggatg
241 aaagggttga ttgatgaagt caatcaagat tttacaaaca gaataaataa gctcaaaaat
301 tcactatttg aatatcagaa gaacaataag gattctcatt cgttgaccac taatataatg
361 gaaattttga gaggcgattt ttcctcagcc aataaccgtg ataataccta caaccgagtg
421 tcagaggatc tgagaagcag aattgaagtc ctgaagcgca aagtcataga aaaagtacag
481 catatccagc ttctgcagaa aaatgttaga gctcagttgg ttgatatgaa acgactggag
541 gtggacattg atattaagat ccgatcttgt cgagggtcat ggagtagggc tttagctcgt
601 gaagtagatc tgaaggacta tgaagatcag cagaagcaac ttgaacaggt cattgccaaa
661 gacttacttc cctctagaga taggcaacac ttaccactga taaaaatgaa accagttcca
721 gacttggttc ccggaaattt taagagccag cttcagaagg tacccccaga gtggaaggca
781 ttaacagaca tgccgcagat gagaatggag ttagagagac ctggtggaaa tgagattact
841 cgaggaggct ccacctctta tggaaccgga tcagagacgg aaagccccag gaaccctagc
901 agtgctggaa gctggaactc tgggagctct ggacctggaa gtactggaaa ccgaaaccct
961 gggagctctg ggactggagg gactgcaacc tggaaacctg ggagctctgg acctggaagt
1021 gctggaagct ggaactctgg gagctctgga actggaagta ctggaaacca aaaccctgga
1081 agtcctagac ctggtagtac cggaacctgg aatcctggca gctctgaacg cggaagtgct
1141 gggcactgga cctctgagag ctctgtatct ggtagtactg gacaatggca ctctgaatct
1201 ggaagtttta ggccagatag cccaggctct gggaacgcga ggcctaacaa cccagactgg
1261 ggcacatttg aagaggtgtc aggaaatgta agtccaggga caaggagaga gtaccacaca
1321 gaaaaactgg tcacttctaa aggagataaa gagctcagga ctggtaaaga gaaggtcacc
1381 tctggtagca caaccaccac gcgtcgttca tgctctaaaa ccgttactaa gactgttatt
1441 ggtcctgatg gtcacaaaga agttaccaaa gaagtggtga cctccgaaga tggttctgac
1501 tgtcccgagg caatggattt aggcacattg tctggcatag gtactctgga tgggttccgt
1561 cataggcacc ctgatgaagc tgccttcttc gacactgcct caactggaaa aacattccca
1621 ggtttcttct cacctatgtt aggagagttt gtcagtgaga ctgagtctag gggctcagaa
1681 tctggcatct tcacaaatac aaaggaatcc agttctcatc accctgggat agctgaattc
1741 ccttcccgtg gtaaatcttc aagttacagc aaacaattta ctagtagcac gagttacaac
1801 agaggagact ccacatttga aagcaagagc tataaaatgg cagatgaggc cggaagtgaa
1861 gccgatcatg aaggaacaca tagcaccaag agagggcatg ctaaatctcg ccctgtcaga
1921 ggtatccaca cttctccttt ggggaagcct tccctgtccc cctagactaa gttaaatatt
1981 tctgcacagt gttcccatgg ccccttgcat ttccttctta actctctgtt acacgtcatt
2041 gaaactacac ttttttggtc tgtttttgtg ctagactgta agttccttgg gggcagggcc
2101 tttgtctgtc tcatctctgt attcccaaat gcctaacagt acagagccat gactcaataa
2161 atacatgtta aatggatgaa tg
//