LOCUS HQ259683 969 bp mRNA linear HUM 02-NOV-2010 DEFINITION Homo sapiens H4K20-specific histone methyltransferase splice variant Set8b (SETD8) mRNA, complete cds, alternatively spliced. ACCESSION HQ259683 VERSION HQ259683.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 969) AUTHORS Abbas,T., Shibata,E., Park,J., Jha,S., Karnani,N. and Dutta,A. TITLE CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation JOURNAL Mol. Cell 40 (1), 9-21 (2010) PUBMED 20932471 REFERENCE 2 (bases 1 to 969) AUTHORS Abbas,T., Shibata,E., Park,J., Jha,S., Karnani,N. and Dutta,A. TITLE Direct Submission JOURNAL Submitted (15-SEP-2010) Biochemistry and Molecular Genetics, Unviersity of Virginia, School of Medicine, 1300 Jefferson Park Ave, Charlottesville, VA 22908, USA FEATURES Location/Qualifiers source 1..969 /db_xref="H-InvDB:HIT000653190_03" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="12" /map="12q24.31" /cell_line="U2OS" /PCR_primers="fwd_name: Set8b-F-primer, fwd_seq: ccggaattcgctagaggcaggaagatgtccaag, rev_name: Set8b-R-primer, rev_seq: aaagcggccgcttaatgcttcagccacgggtgggctt" /note="osteosarcoma-derived cell line" gene 1..969 /gene="SETD8" /note="KMT5A; PR-Set7; SET07; SET8" CDS 1..969 /gene="SETD8" /EC_number="2.1.1.43" /function="histone H4-lysine 20-specific methyl-transferase" /note="alternatively spliced; splice variant of the human Set8/Pr-Set7 histone H4K20 monomethyl transferase; SET domain containing (lysine methyltransferase) 8; lacks exon 2" /codon_start=1 /product="H4K20-specific histone methyltransferase splice variant Set8b" /protein_id="ADP08984.1" /translation="MARGRKMSKPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEEN SVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKS EAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRS SRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGD LIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQ TKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH" BASE COUNT 311 a 252 c 245 g 161 t ORIGIN 1 atggctagag gcaggaagat gtccaagccc cgcaccgacg gggagaacgt atttaccggg 61 cagtcaaaga tctattccta catgagcccg aacaaatgct ctggaatgcg tttccccctt 121 caggaagaga actcagttac acatcacgaa gtcaaatgcc aggggaaacc attagccgga 181 atctacagga aacgagaaga gaaaagaaat gctgggaacg cagtacggag cgccatgaag 241 tccgaggaac agaagatcaa agacgccagg aaaggtcccc tggtaccttt tccaaaccaa 301 aaatctgaag cagcagaacc tccaaaaact ccaccctcat cttgtgattc caccaatgca 361 gccatcgcca agcaagccct gaaaaagccc atcaagggca aacaggcccc ccgaaaaaaa 421 gctcaaggaa aaacgcaaca gaatcgcaaa cttacggatt tctaccctgt ccgaaggagc 481 tccaggaaga gcaaagccga gctgcagtct gaagaaagga aaagaataga tgaattgatt 541 gaaagtggga aggaagaagg aatgaagatt gacctcatcg atggcaaagg caggggtgtg 601 attgccacca agcagttctc ccggggtgac tttgtggtgg aataccacgg ggacctcatc 661 gagatcaccg acgccaagaa acgggaggct ctgtacgcac aggacccttc cacgggctgc 721 tacatgtact attttcagta tctgagcaaa acctactgcg tggatgcaac tagagagaca 781 aatcgcctag gaagactgat caatcacagc aaatgtggga actgccaaac caaactgcac 841 gacatcgacg gcgtacctca cctcatcctc atcgcctccc gagacatcgc ggctggggag 901 gagctcctgt atgactatgg ggaccgcagc aaggcttcca ttgaagccca cccgtggctg 961 aagcattaa //