LOCUS       HQ259683                 969 bp    mRNA    linear   HUM 02-NOV-2010
DEFINITION  Homo sapiens H4K20-specific histone methyltransferase splice
            variant Set8b (SETD8) mRNA, complete cds, alternatively spliced.
ACCESSION   HQ259683
VERSION     HQ259683.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 969)
  AUTHORS   Abbas,T., Shibata,E., Park,J., Jha,S., Karnani,N. and Dutta,A.
  TITLE     CRL4(Cdt2) regulates cell proliferation and histone gene expression
            by targeting PR-Set7/Set8 for degradation
  JOURNAL   Mol. Cell 40 (1), 9-21 (2010)
   PUBMED   20932471
REFERENCE   2  (bases 1 to 969)
  AUTHORS   Abbas,T., Shibata,E., Park,J., Jha,S., Karnani,N. and Dutta,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (15-SEP-2010) Biochemistry and Molecular Genetics,
            Unviersity of Virginia, School of Medicine, 1300 Jefferson Park
            Ave, Charlottesville, VA 22908, USA
FEATURES             Location/Qualifiers
     source          1..969
                     /db_xref="H-InvDB:HIT000653190_03"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
                     /cell_line="U2OS"
                     /PCR_primers="fwd_name: Set8b-F-primer, fwd_seq:
                     ccggaattcgctagaggcaggaagatgtccaag, rev_name:
                     Set8b-R-primer, rev_seq:
                     aaagcggccgcttaatgcttcagccacgggtgggctt"
                     /note="osteosarcoma-derived cell line"
     gene            1..969
                     /gene="SETD8"
                     /note="KMT5A; PR-Set7; SET07; SET8"
     CDS             1..969
                     /gene="SETD8"
                     /EC_number="2.1.1.43"
                     /function="histone H4-lysine 20-specific
                     methyl-transferase"
                     /note="alternatively spliced; splice variant of the human
                     Set8/Pr-Set7 histone H4K20 monomethyl transferase; SET
                     domain containing (lysine methyltransferase) 8; lacks exon
                     2"
                     /codon_start=1
                     /product="H4K20-specific histone methyltransferase splice
                     variant Set8b"
                     /protein_id="ADP08984.1"
                     /translation="MARGRKMSKPRTDGENVFTGQSKIYSYMSPNKCSGMRFPLQEEN
                     SVTHHEVKCQGKPLAGIYRKREEKRNAGNAVRSAMKSEEQKIKDARKGPLVPFPNQKS
                     EAAEPPKTPPSSCDSTNAAIAKQALKKPIKGKQAPRKKAQGKTQQNRKLTDFYPVRRS
                     SRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGD
                     LIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHSKCGNCQ
                     TKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAHPWLKH"
BASE COUNT          311 a          252 c          245 g          161 t
ORIGIN      
        1 atggctagag gcaggaagat gtccaagccc cgcaccgacg gggagaacgt atttaccggg
       61 cagtcaaaga tctattccta catgagcccg aacaaatgct ctggaatgcg tttccccctt
      121 caggaagaga actcagttac acatcacgaa gtcaaatgcc aggggaaacc attagccgga
      181 atctacagga aacgagaaga gaaaagaaat gctgggaacg cagtacggag cgccatgaag
      241 tccgaggaac agaagatcaa agacgccagg aaaggtcccc tggtaccttt tccaaaccaa
      301 aaatctgaag cagcagaacc tccaaaaact ccaccctcat cttgtgattc caccaatgca
      361 gccatcgcca agcaagccct gaaaaagccc atcaagggca aacaggcccc ccgaaaaaaa
      421 gctcaaggaa aaacgcaaca gaatcgcaaa cttacggatt tctaccctgt ccgaaggagc
      481 tccaggaaga gcaaagccga gctgcagtct gaagaaagga aaagaataga tgaattgatt
      541 gaaagtggga aggaagaagg aatgaagatt gacctcatcg atggcaaagg caggggtgtg
      601 attgccacca agcagttctc ccggggtgac tttgtggtgg aataccacgg ggacctcatc
      661 gagatcaccg acgccaagaa acgggaggct ctgtacgcac aggacccttc cacgggctgc
      721 tacatgtact attttcagta tctgagcaaa acctactgcg tggatgcaac tagagagaca
      781 aatcgcctag gaagactgat caatcacagc aaatgtggga actgccaaac caaactgcac
      841 gacatcgacg gcgtacctca cctcatcctc atcgcctccc gagacatcgc ggctggggag
      901 gagctcctgt atgactatgg ggaccgcagc aaggcttcca ttgaagccca cccgtggctg
      961 aagcattaa
//