LOCUS HQ171445 2883 bp mRNA linear HUM 30-NOV-2011
DEFINITION Homo sapiens cyclin dependent kinase 5 transcript variant (CDKL5)
mRNA, complete cds, alternatively spliced.
ACCESSION HQ171445
VERSION HQ171445.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2883)
AUTHORS Williamson,S.L.
TITLE A Novel Transcript of Cyclin-Dependent Kinase-like 5 (CDKL5) has an
Alternative C-terminus
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 2883)
AUTHORS Williamson,S.L.
TITLE Direct Submission
JOURNAL Submitted (23-AUG-2010) NSW Centre for Rett Syndrome Research,
Research Building, The Children's Hospital at Westmead, Hawkesbury
Rd, Westmead, NSW 2145, Australia
FEATURES Location/Qualifiers
source 1..2883
/db_xref="H-InvDB:HIT000715137"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="SH-SY5Y"
gene <1..>2883
/gene="CDKL5"
CDS 1..2883
/gene="CDKL5"
/note="retains a portion of intron 18 resulting in an
alternative C-terminus; alternatively spliced"
/codon_start=1
/product="cyclin dependent kinase 5 transcript variant"
/protein_id="ADN38258.1"
/translation="MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKF
KDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEE
MPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNL
SEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEID
QLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKN
LLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTA
LQSHHRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGS
TSKDLTNNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRSQQNRHSFMES
SQSKAGTLQPNEKQSRHSYIDTIPQSSRSPSYRTKAKSHGALSDSKSVSNLSEARAQI
AEPSTSRYFPSSCLDLNSPTSPTPTRHSDTRTLLSPSGRNNRNEGTLDSRRTTTRHSK
TMEELKLPEHMDSSHSHSLSAPHESFSYGLGYTSPFSSQQRPHRHSMYVTRDKVRAKG
LDGSLSIGQGMAARANSLQLLSPQPGEQLPPEMTVARSSVKETSREGTSSFHTRQKSE
GGVYHDPHSDDGTAPKENRHLYNDPVPRRVGSFYRVPSPRPDNSFHENNVSTRVSSLP
SESSSGTNHSKRQPAFDPWKSPENISHSEQLKEKEKQGFFRSMKKKKKKSQTVPNSDS
PDLLTLQKSIHSASTPSSRPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSD
PRFQPLTAQQTKNSFSEIRIHPLSQASGGSSNIRQEPAPKGRPALQLPGQMDPGWHVS
SVTRSATEGPSYSEQLGAKSGPNGHPYNRTNRSRMPNLNDLKETAL"
BASE COUNT 885 a 731 c 631 g 636 t
ORIGIN
1 atgaagattc ctaacattgg taatgtgatg aataaatttg agatccttgg ggttgtaggt
61 gaaggagcct atggagttgt acttaaatgc agacacaagg aaacacatga aattgtggcg
121 atcaagaaat tcaaggacag tgaagaaaat gaagaagtca aagaaacgac tttacgagag
181 cttaaaatgc ttcggactct caagcaggaa aacattgtgg agttgaagga agcatttcgt
241 cggaggggaa agttgtactt ggtgtttgag tatgttgaaa aaaatatgct cgaattgctg
301 gaagaaatgc caaatggagt tccacctgag aaagtaaaaa gctacatcta tcagctaatc
361 aaggctattc actggtgcca taagaatgat attgtccatc gagatataaa accagaaaat
421 ctcttaatca gccacaatga tgtcctaaaa ctgtgtgact ttggttttgc tcgtaatctg
481 tcagaaggca ataatgctaa ttacacagag tacgttgcca ccagatggta tcggtcccca
541 gaactcttac ttggcgctcc ctatggaaag tccgtggaca tgtggtcggt gggctgtatt
601 cttggggagc ttagcgatgg acagccttta tttcctggag aaagtgaaat tgaccaactt
661 tttactattc agaaggtgct aggaccactt ccatctgagc agatgaagct tttctacagt
721 aatcctcgct tccatgggct ccggtttcca gctgttaacc atcctcagtc cttggaaaga
781 agataccttg gaattttgaa tagtgttcta cttgacctaa tgaagaattt actgaagttg
841 gacccagctg acagatactt gacagaacag tgtttgaatc accctacatt tcaaacccag
901 agacttctgg atcgttctcc ttcaaggtca gcaaaaagaa aaccttacca tgtggaaagc
961 agcacattgt ctaatagaaa ccaagccggc aaaagtactg ccttgcagtc tcaccacaga
1021 tctaacagca aggacatcca gaacctgagt gtaggcctgc cccgggctga cgaaggtctc
1081 cctgccaatg aaagcttcct aaatggaaac cttgctggag ctagtcttag tccactgcac
1141 accaaaacct accaagcaag cagccagcct gggtctacca gcaaagatct caccaacaac
1201 aacataccac accttcttag cccaaaagaa gccaagtcaa aaacagagtt tgattttaat
1261 attgacccaa agccttcaga aggcccaggg acaaagtacc tcaagtcaaa cagcagatct
1321 cagcagaacc gccactcatt catggaaagc tctcaaagca aagctgggac actgcagccc
1381 aatgaaaagc agagtcggca tagctatatt gacacaattc cccagtcctc taggagtccc
1441 tcctacagga ccaaggccaa aagccatggg gcactgagtg actccaagtc tgtgagcaac
1501 ctttctgaag ccagggccca aattgcggag cccagtacca gtaggtactt cccatctagc
1561 tgcttagact tgaattctcc caccagccca acccccacca gacacagtga cacgagaact
1621 ttgctcagcc cttctggaag aaataaccga aatgagggaa cgctggactc acgtcgaacc
1681 acaaccagac attctaagac gatggaggaa ttgaagctgc cggagcacat ggacagtagc
1741 cattcccatt cactgtctgc acctcacgaa tctttttctt atggactggg ctacaccagc
1801 cccttttctt cccagcaacg tcctcatagg cattctatgt atgtgacccg tgacaaagtg
1861 agagccaagg gcttggatgg aagcttgagc atagggcaag ggatggcagc tagagccaac
1921 agcctgcaac tcttgtcacc ccagcctgga gaacagctcc ctccagagat gactgtggca
1981 agatcttcgg tcaaagagac ctccagagaa ggcacctctt ccttccatac acgccagaag
2041 tctgagggtg gagtgtatca tgacccacac tctgatgatg gcacagcccc caaagaaaat
2101 agacacctat acaatgatcc tgtgccaagg agagttggta gcttttacag agtgccatct
2161 ccacgtccag acaattcttt ccatgaaaat aatgtgtcaa ctagagtttc ttctctacca
2221 tcagagagca gttctggaac caaccactca aaaagacaac cagcattcga tccatggaaa
2281 agtcctgaaa atattagtca ttcggagcaa ctcaaggaaa aagagaagca aggatttttc
2341 aggtcaatga aaaagaaaaa gaagaaatct caaacagtac ccaattccga cagccctgat
2401 cttctgacgt tgcagaaatc cattcattct gctagcactc caagcagcag accaaaggag
2461 tggcgccccg agaagatctc agatctgcag acccaaagcc agccattaaa gtcactgcgc
2521 aagttgttac atctctcttc ggcctcaaat cacccggctt cctcagatcc ccgcttccag
2581 cccttaacag ctcaacaaac caaaaattcc ttctcagaaa ttcggattca ccccctgagc
2641 caggcctctg gcgggagcag caacatccgg caggaacccg caccgaaggg caggccagcc
2701 ctccagctgc caggtcagat ggatcctggt tggcatgtgt cctctgtgac caggagtgcc
2761 acagagggcc cttcctactc tgaacagctg ggtgccaaaa gtgggccaaa tgggcacccc
2821 tataacagaa caaatcgctc acgaatgcca aatctgaatg atttaaaaga gacagccttg
2881 taa
//