LOCUS HM191478 4869 bp mRNA linear HUM 29-APR-2011
DEFINITION Homo sapiens formin homology 2 domain containing 3 variant (FHOD3)
mRNA, complete cds, alternatively spliced.
ACCESSION HM191478
VERSION HM191478.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4869)
AUTHORS Iskratsch,T., Lange,S., Dwyer,J., Kho,A.L., dos Remedios,C. and
Ehler,E.
TITLE Formin follows function: a muscle-specific isoform of FHOD3 is
regulated by CK2 phosphorylation and promotes myofibril maintenance
JOURNAL J. Cell Biol. 191 (6), 1159-1172 (2010)
PUBMED 21149568
REFERENCE 2 (bases 1 to 4869)
AUTHORS Iskratsch,T.
TITLE Direct Submission
JOURNAL Submitted (02-MAY-2010) Randall Division of Cell and Molecular
Biophysics and Cardiovascular Division, King's College London, New
Hunt's House, Guy's Campus, London SE1 1UL, UK
FEATURES Location/Qualifiers
source 1..4869
/db_xref="H-InvDB:HIT000649266"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="heart"
gene 1..4869
/gene="FHOD3"
/gene_synonym="FHOS2"
CDS 1..4869
/gene="FHOD3"
/gene_synonym="FHOS2"
/note="actin assembly factor; alternatively spliced"
/codon_start=1
/product="formin homology 2 domain containing 3 variant"
/protein_id="ADL62709.1"
/translation="MATLACRVQFLDDTDPFNSTNFPEPSRPPLFTFREDLALGTQLA
GVHRLLQAPHKLDDCTLQLSHNGAYLDLEATLAEQRDELEGFQDDAGRGKKHSIILRT
QLSVRVHACIEKLYNSSGRDLRRALFSLKQIFQDDKDLVHEFVVAEGLTCLIKVGAEA
DQNYQNYILRALGQIMLYVDGMNGVINRNETIQWLYTLIGSEFRLVVKTALKLLLVFV
EYSESNAPLLIQAVTAVDTKRGVKPWSNIMEILEEKDGVDTELLVYAMTLVNKTLSGL
PDQDTFYDVVDCLEELGIAAVSQRHLNKKGTDLDLVEQLNIYEVALRHEDGDETTEPP
PSGCRDRRRASVCSSGGGEHRGLDRRRSRRHSVQSIKSTLSAPTSPCSQSAPSFKPNQ
VRDLREKEEEEEEEQPITEPSSEEEREDDASCQGKDSKVGAASGQSPTGRDAAPKSSA
LPAVSNASSQGKPLLVGTAGGTTWHSGSSGSEATPSALLSPPASAARPSSATPGSLKV
SPTIDKLPYVPHSPFHLFSYDFEDSSLSTKEKEAESQKENSSSDSFSLSTYSASEPYH
FRSFSSNRYSNFGNNSYHSSRPSSGSSVPTTPTSSVSPPQGARLERSSPSGLLTSSFR
QHQESLAAERERRRQEREERLQRIEREERNKFSRDYLDKREEQRQAREERYKYLEQLA
AEEHEKELRSRSVSRGRADLSLDLTSPAAPACLAPLGHSPSSSDSQEALTVSASSPGT
PHHPQASAGDPEPESEAEPEAEAGAGQVADEAAQDIASAHEGAETEVEQALEQEPEER
ASLSEKERQNEGVNERDNCSASSVSSSSSTLEREEKEDKLPRDRTTGLWPAGVQDAGV
NGQCGDILTNKRFMLDMLYAHNRKSPDDEEKGDGEAGRTQQEAEAVASLATRISTLQA
NSQTQDESVRRVDVGCLDNRGSVKAFAEKFNSGDLGRGSISPDAEPNDKVPETAPVQP
KTESDYIWDQLMANPRELRIQDMDFTDLGEEDDIDVLDVDLGHREAPGPPPPPPPTFL
GLPPPPPPPLLDSIPPPPVPGNLLVPPPPVFNAPQGLGWSQVPRGQPTFTKKKKTIRL
FWNEVRPFDWPCKNNRRCREFLWSKLEPIKVDTSRLEHLFESKSKELSVSKKTAADGK
RQEIIVLDSKRSNAINIGLTVLPPPRTIKIAILNFDEYALNKEGIEKILTMIPTDEEK
QKIQEAQLANPEIPLGSAEQFLLTLSSISELSARLHLWAFKMDYETTEKEVAEPLLDL
KEGIDQLENNKTLGFILSTLLAIGNFLNGTNAKAFELSYLEKVPEVKDTVHKQSLLHH
VCTMVVENFPDSSDLYSEIGAITRSAKVDFDQLQDNLCQMERRCKASWDHLKAIAKHE
MKPVLKQRMSEFLKDCAERIIILKIVHRRIINRFHSFLLFMGHPPYAIREVNINKFCR
IISEFALEYRTTRERVLQQKQKRANHRERNKTRGKMITDTDEEEEVESGKFSGSSPAP
PSQPQGLSYAEDAAEHENMKAVLKTSSPSVEDATPALGVRTRSRASRGSTSSWTMGTD
DSPNVTDDAADEIMDRIVKSATQVPSQRVVPRERKRSRANRKSLRRTLKSGLTPEEAR
ALGLVGTSELQL"
exon 1..165
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=1
exon 166..272
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=2
exon 273..337
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=3
exon 338..405
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=4
exon 406..511
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=5
exon 512..606
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=6
exon 607..718
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=7
exon 719..813
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=8
exon 814..957
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=9
exon 958..1196
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=10
exon 1197..1286
/gene="FHOD3"
/gene_synonym="FHOS2"
/note="alternative exon"
/number=11
exon 1287..1646
/gene="FHOD3"
/gene_synonym="FHOS2"
/note="alternative exon"
/number=12
exon 1647..1721
/gene="FHOD3"
/gene_synonym="FHOS2"
/note="alternative exon"
/number=13
exon 1722..1835
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=14
exon 1836..1970
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=15
exon 1971..2021
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=16
exon 2022..2236
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=17
exon 2237..2533
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=18
exon 2534..3417
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=19
exon 3418..3576
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=20
exon 3577..3759
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=21
exon 3760..3879
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=22
exon 3880..4041
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=23
exon 4042..4232
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=24
exon 4233..4425
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=25
exon 4426..4449
/gene="FHOD3"
/gene_synonym="FHOS2"
/note="alternative exon"
/number=26
exon 4450..4624
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=27
exon 4625..4786
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=28
exon 4787..4869
/gene="FHOD3"
/gene_synonym="FHOS2"
/number=29
BASE COUNT 1269 a 1306 c 1352 g 942 t
ORIGIN
1 atggccacgc tggcttgccg ggtgcagttc ttggacgaca cggacccttt caacagcacc
61 aacttccccg agcccagccg gccgccgctg ttcacgttcc gcgaggacct cgcgctcggc
121 acccagctgg cgggggtcca taggctgctg caggcgccgc acaagctgga tgactgtact
181 ctgcagctct ctcacaatgg cgcctacctg gatttggagg ccaccctggc agagcagcgg
241 gatgagttgg aaggcttcca ggatgacgcc gggcggggca agaagcacag catcatccta
301 aggacgcagc tgtctgtgag ggtccatgcc tgcatcgaaa aactatacaa ctccagcgga
361 cgagatttga gaagggccct cttctccctg aagcagatat ttcaggatga caaggatttg
421 gtgcatgaat ttgtagtggc tgaaggtctg acatgtttga tcaaggtggg agctgaggct
481 gatcagaact atcagaacta catcttaagg gctttgggcc agattatgtt gtatgtggat
541 ggaatgaatg gagtaataaa ccgcaatgaa accattcagt ggctgtacac tctcattggg
601 tcagagttcc gcctggtggt gaagacagcc ctgaagctgc tgctcgtctt tgtagagtac
661 tcggagtcca acgcacctct cctaattcag gctgtcactg ctgttgacac gaaaagaggg
721 gtcaaacctt ggtcaaatat catggaaatc ctggaggaaa aagatggagt tgatacggag
781 ctactggttt atgcaatgac tttggtgaac aagacgttat caggactacc agaccaagac
841 accttctacg acgtcgtgga ctgcctggag gagctgggca ttgctgctgt gtcccagagg
901 cacttgaaca agaaagggac tgacctggac ttagtggagc aactcaacat ttatgaggtg
961 gcgctcaggc acgaggatgg cgatgagacc acggagccac cccccagtgg gtgccgggac
1021 cggaggaggg ccagcgtgtg ttccagtggc ggaggcgagc accggggcct ggaccgcaga
1081 aggagccgca ggcactcggt gcagagcatc aagagcaccc tgtcggcccc caccagtccc
1141 tgctcccagt cagctcccag cttcaagccc aaccaagtgc gagatctgcg tgaaaaggag
1201 gaggaggagg aagaggagca gccaatcacg gagcccagtt ccgaagaaga gagagaggat
1261 gatgcttcct gtcagggcaa ggacagcaag gtcggcgctg cctcagggca gagccccact
1321 ggaagggatg ctgctcccaa gagctctgcc ctccctgctg tctcgaatgc cagctcgcag
1381 ggaaagccgc ttctggttgg cactgctggc gggaccacct ggcacagtgg gtcctctggg
1441 tctgaggcca ccccatctgc cctcctgtca ccccctgcct cagctgctcg gccctcctcc
1501 gccacaccag gctccctgaa ggtgtcaccg accatagaca agctgcccta cgtgccccac
1561 agccccttcc acctcttctc ctatgacttt gaggactcct ccctgtccac caaggagaag
1621 gaagcagagt cccagaagga aaacagttcc tctgattctt tctctttgag cacatattct
1681 gcctctgagc cttaccactt ccgatctttc tcttctaata gatacagcaa ttttggcaat
1741 aactcttatc actcctcaag accctcatct ggatccagtg tgcccaccac ccccacatca
1801 tccgtctcac ccccacaggg ggccaggttg gaaaggtcat caccgagtgg tcttctcaca
1861 tcatccttca ggcagcacca agagtcactg gcagcagaga gagagaggcg gcggcaggag
1921 agagaagaaa ggttgcagag aatagagcgg gaagaaagaa acaaattcag ccgagattat
1981 ttagacaaaa gagaggagca aaggcaagca agagaagaaa gatacaaata cttggaacag
2041 ttggcagctg aggagcacga gaaggagctg agaagccgga gtgtgagccg gggcagagcc
2101 gacctctcct tggacctgac ctcgccagca gccccagcct gcctggctcc tctgggccat
2161 agcccctcat cttcagactc tcaagaggct ctcacggtgt ctgcctcctc cccaggaacc
2221 cctcaccatc cccaagcaag tgccggggat cctgaacccg aatcagaggc agaaccggaa
2281 gcagaggcag gggcggggca ggttgctgat gaagctgccc aggacatagc ctctgcccac
2341 gagggtgcag agactgaagt ggagcaggca ctagagcaag agccggaaga aagagcctcc
2401 ctcagtgaaa aagagaggca gaacgagggg gtgaacgaga gggacaactg ctctgcctcc
2461 agcgtctcgt cctccagcag cacgttggag agggaggaga aggaggacaa gctccccagg
2521 gacaggacaa ctggtttgtg gcccgcaggt gtccaggatg caggtgtaaa tggacagtgt
2581 ggcgacatcc tcaccaacaa acggttcatg cttgacatgc tgtatgccca taacaggaag
2641 tctccggatg atgaggagaa gggggatggg gaggctggga ggacccagca ggaggcagag
2701 gcggtagcca gccttgctac caggatatcc accctgcagg ccaactctca gacccaggat
2761 gagagtgtca ggagggtgga tgtcggctgt ttggacaatc ggggcagtgt gaaagcattt
2821 gctgagaaat tcaacagtgg ggacctgggg agaggttcca tctcccctga tgctgagccc
2881 aatgacaagg tcccagaaac ggcgccggtg cagccgaaga cagagtctga ttacatctgg
2941 gaccagctca tggccaatcc aagagagctc agaatccaag acatggattt cacagaccta
3001 ggggaggagg acgatatcga tgttttggat gtggatctgg gccaccggga ggccccaggg
3061 ccacctcctc caccccctcc cacctttctg ggtttgccac ccccaccccc tccacccctg
3121 ttggacagca ttcctccccc acctgtcccc ggtaatttat tggttcctcc tcctcctgtg
3181 ttcaacgctc ctcagggctt agggtggtcc caggtaccca ggggtcagcc cacattcact
3241 aagaaaaaga agaccatccg tttgttctgg aatgaagttc ggccttttga ctggccatgt
3301 aaaaacaacc gacgctgcag agaattcctg tggtcaaaac tggaacccat taaggtggac
3361 acttccagac tggagcacct gtttgagtct aaatccaagg aactgtctgt ctcaaagaaa
3421 actgctgcag atggaaaaag gcaagagatc attgttctgg attccaagag gagtaacgcc
3481 atcaatattg gtctgacggt gctgccccct ccaaggacga ttaagatcgc cattttgaat
3541 tttgatgagt atgccttaaa caaagaagga atcgagaaaa ttctaacgat gattcccacc
3601 gatgaggaga agcagaaaat ccaggaagct cagctggcca accctgaaat ccccctgggc
3661 agtgcagagc agttcctcct caccctgtcc tccatcagcg agctctctgc acgacttcac
3721 ctctgggcat tcaaaatgga ttatgaaact acagaaaagg aagtagcaga accactcctg
3781 gacctgaagg aaggaataga ccagttggag aacaataaaa ccttgggctt tatcctgtct
3841 actctcttag ccattgggaa ctttctaaat ggaactaatg ccaaagcgtt tgagttaagc
3901 tacctcgaga aggttccaga agtcaaagac acagtgcaca agcagtcgct tctccaccat
3961 gtgtgcacca tggtggtaga aaacttccca gacagctccg atctgtactc ggagatcggg
4021 gccatcacca ggtcagccaa ggttgacttt gatcaacttc aggataattt atgtcagatg
4081 gagagaagat gcaaagcttc atgggatcac ctcaaggcaa ttgcaaaaca tgaaatgaaa
4141 ccagttttaa aacaacggat gtcagagttc ctgaaagact gtgcagagcg aattataatt
4201 ttaaagattg tccatagaag gataatcaac agattccact cctttttact ctttatgggc
4261 catccacctt atgcaattcg ggaagtgaac ataaacaaat tctgcaggat tattagtgaa
4321 tttgcactag agtatcgcac aaccagggaa agggttttgc agcagaaaca gaaacgggcc
4381 aaccacagag agagaaataa gaccagaggg aagatgatca ccgatactga tgaggaggag
4441 gaagttgagt ctggcaagtt ctccggcagt tctccggcgc ccccaagcca gccgcagggt
4501 ctgagctatg cggaggacgc ggctgagcac gagaacatga aggctgtgct gaaaacctcg
4561 tccccctccg tggaggacgc cacccccgcg ctgggcgtcc gcacacgcag ccgagcaagc
4621 cgaggatcca ctagttcctg gactatggga actgatgact cgcccaatgt cacagatgat
4681 gcagctgatg agatcatgga ccgcatcgtc aagtcagcca cccaagtgcc cagtcagcga
4741 gtggtgccga gggagaggaa acgatcccgg gccaaccgga aatctttgcg aagaaccctg
4801 aagagcggcc tgaccccaga agaagccaga gccctgggct tggttggcac ctcggagttg
4861 cagctgtga
//