LOCUS HM068883 1503 bp mRNA linear HUM 03-SEP-2010
DEFINITION Homo sapiens neuregulin 3 variant 12 (NRG3) mRNA, complete cds,
alternatively spliced.
ACCESSION HM068883
VERSION HM068883.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1503)
AUTHORS Kao,W.T., Wang,Y., Kleinman,J.E., Lipska,B.K., Hyde,T.M.,
Weinberger,D.R. and Law,A.J.
TITLE Common genetic variation in Neuregulin 3 (NRG3) influences risk for
schizophrenia and impacts NRG3 expression in human brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15619-15624 (2010)
PUBMED 20713722
REFERENCE 2 (bases 1 to 1503)
AUTHORS Kao,W.T.K. and Law,A.J.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2010) Clinical Brain Disorders Branch, NIMH/NIH,
10 Center Drive, Building 10, Room 3C-105, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..1503
/db_xref="H-InvDB:HIT000649177"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22"
/clone="WKCBDB33F"
/tissue_type="brain"
/dev_stage="adult"
gene 1..1503
/gene="NRG3"
CDS 1..1503
/gene="NRG3"
/note="growth factor; alternatively spliced"
/codon_start=1
/product="neuregulin 3 variant 12"
/protein_id="ADK90030.1"
/translation="MECGIPPTLVCVGRGGGLHTVGVFHVLSQLISLCTIPEVFKEKP
KINIIIWYYFPSAWRTCFNISSSVGLLLTNSYKFYTTTYSTERSEHFKPCRDKDLAYC
LNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEV
YQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMA
KSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRS
LSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGYS
SSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQ
MPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARR
SEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK"
BASE COUNT 458 a 345 c 345 g 355 t
ORIGIN
1 atggagtgtg gtatacctcc aacccttgta tgcgttggga gaggaggggg actacacacg
61 gtaggggtat ttcatgttct ttctcaattg atttccttgt gtaccattcc ggaggtcttt
121 aaagaaaagc ccaagatcaa tataatcatc tggtattatt ttccttctgc ctggaggact
181 tgctttaaca tttcaagtag tgtgggtctg ctgctgacga attcatacaa attttatacg
241 acgacatatt ccacagagcg atccgagcac ttcaaaccct gccgagacaa ggaccttgca
301 tactgtctca atgatggcga gtgctttgtg atcgaaaccc tgaccggatc ccataaacac
361 tgtcggtgca aagaaggcta ccaaggagtc cgttgtgatc aatttctgcc gaaaactgat
421 tccatcttat cggatccaac agaccacttg gggattgaat tcatggagag tgaagaagtt
481 tatcaaaggc aggtgctgtc aatttcatgt atcatctttg gaattgtcat cgtgggcatg
541 ttctgtgcag cattctactt caaaagcaag aaacaagcta aacaaatcca agagcagctg
601 aaagtgccac aaaatggtaa aagctacagt ctcaaagcat ccagcacaat ggcaaagtca
661 gagaacttgg tgaagagcca tgtccagctg caaaattatt caaaggtgga aaggcatcct
721 gtgactgcat tggagaaaat gatggagtca agttttgtcg gcccccagtc attccctgag
781 gtcccttctc ctgacagagg aagccagtct gtcaaacacc acaggagtct atcctcttgc
841 tgcagcccag ggcaaagaag tggcatgctc cataggaatg ccttcagaag gacacccccg
901 tcaccccgaa gtaggctagg tggaattgtg ggaccagcat atcagcaact cgaagaatca
961 aggatcccag accaggatac gataccttgc caagggtatt catccagtgg tttaaaaacc
1021 caacgaaata catcaataaa tatgcaactg ccttcaagag agacaaaccc ctattttaat
1081 agcttggagc aaaaggacct ggtgggctat tcatccacaa gggccagttc tgtgcccatc
1141 atcccttcag tgggtttaga ggaaacctgc ctgcaaatgc cagggatttc tgaagtcaaa
1201 agcatcaaat ggtgcaaaaa ctcctattca gctgacgttg tcaatgtgag tattccagtc
1261 agcgattgtc ttatagcaga acaacaagaa gtgaaaatat tgctagaaac tgtccaggag
1321 cagatccgaa ttctgactga tgccagacgg tcagaagact acgaactggc cagcgtagaa
1381 accgaggaca gtgcaagcga aaacacagcc tttctccccc tgagtcccac agccaaatca
1441 gaacgagagg cgcaatttgt cttaagaaat gaaatacaaa gagactctgc attgaccaag
1501 tga
//