LOCUS HM068882 1575 bp mRNA linear HUM 03-SEP-2010
DEFINITION Homo sapiens neuregulin 3 variant 11 (NRG3) mRNA, complete cds,
alternatively spliced.
ACCESSION HM068882
VERSION HM068882.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1575)
AUTHORS Kao,W.T., Wang,Y., Kleinman,J.E., Lipska,B.K., Hyde,T.M.,
Weinberger,D.R. and Law,A.J.
TITLE Common genetic variation in Neuregulin 3 (NRG3) influences risk for
schizophrenia and impacts NRG3 expression in human brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15619-15624 (2010)
PUBMED 20713722
REFERENCE 2 (bases 1 to 1575)
AUTHORS Kao,W.T.K. and Law,A.J.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2010) Clinical Brain Disorders Branch, NIMH/NIH,
10 Center Drive, Building 10, Room 3C-105, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..1575
/db_xref="H-InvDB:HIT000649176"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22"
/clone="WKCBDB26F"
/tissue_type="brain"
/dev_stage="adult"
gene 1..1575
/gene="NRG3"
CDS 1..1575
/gene="NRG3"
/note="growth factor; alternatively spliced"
/codon_start=1
/product="neuregulin 3 variant 11"
/protein_id="ADK90029.1"
/translation="MECGIPPTLVCVGRGGGLHTVGVFHVLSQLISLCTIPEVFKEKP
KINIIIWYYFPSAWRTCFNISSSVGLLLTNSYKFYTTTYSTERSEHFKPCRDKDLAYC
LNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEV
YQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMA
KSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRS
LSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIE
VRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLV
GYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIA
EQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREA
QFVLRNEIQRDSALTK"
BASE COUNT 479 a 361 c 363 g 372 t
ORIGIN
1 atggagtgtg gtatacctcc aacccttgta tgcgttggga gaggaggggg actacacacg
61 gtaggggtat ttcatgttct ttctcaattg atttccttgt gtaccattcc ggaggtcttt
121 aaagaaaagc ccaagatcaa tataatcatc tggtattatt ttccttctgc ctggaggact
181 tgctttaaca tttcaagtag tgtgggtctg ctgctgacga attcatacaa attttatacg
241 acgacatatt ccacagagcg atccgagcac ttcaaaccct gccgagacaa ggaccttgca
301 tactgtctca atgatggcga gtgctttgtg atcgaaaccc tgaccggatc ccataaacac
361 tgtcggtgca aagaaggcta ccaaggagtc cgttgtgatc aatttctgcc gaaaactgat
421 tccatcttat cggatccaac agaccacttg gggattgaat tcatggagag tgaagaagtt
481 tatcaaaggc aggtgctgtc aatttcatgt atcatctttg gaattgtcat cgtgggcatg
541 ttctgtgcag cattctactt caaaagcaag aaacaagcta aacaaatcca agagcagctg
601 aaagtgccac aaaatggtaa aagctacagt ctcaaagcat ccagcacaat ggcaaagtca
661 gagaacttgg tgaagagcca tgtccagctg caaaattatt caaaggtgga aaggcatcct
721 gtgactgcat tggagaaaat gatggagtca agttttgtcg gcccccagtc attccctgag
781 gtcccttctc ctgacagagg aagccagtct gtcaaacacc acaggagtct atcctcttgc
841 tgcagcccag ggcaaagaag tggcatgctc cataggaatg ccttcagaag gacacccccg
901 tcaccccgaa gtaggctagg tggaattgtg ggaccagcat atcagcaact cgaagaatca
961 aggatcccag accaggatac gataccttgc caagggatag aggtcaggaa gactatatcc
1021 cacctgccta tacagctgtg gtgtgttgaa agacccctgg acttaaagta ttcatccagt
1081 ggtttaaaaa cccaacgaaa tacatcaata aatatgcaac tgccttcaag agagacaaac
1141 ccctatttta atagcttgga gcaaaaggac ctggtgggct attcatccac aagggccagt
1201 tctgtgccca tcatcccttc agtgggttta gaggaaacct gcctgcaaat gccagggatt
1261 tctgaagtca aaagcatcaa atggtgcaaa aactcctatt cagctgacgt tgtcaatgtg
1321 agtattccag tcagcgattg tcttatagca gaacaacaag aagtgaaaat attgctagaa
1381 actgtccagg agcagatccg aattctgact gatgccagac ggtcagaaga ctacgaactg
1441 gccagcgtag aaaccgagga cagtgcaagc gaaaacacag cctttctccc cctgagtccc
1501 acagccaaat cagaacgaga ggcgcaattt gtcttaagaa atgaaataca aagagactct
1561 gcattgacca agtga
//