LOCUS HM068876 1400 bp mRNA linear HUM 03-SEP-2010
DEFINITION Homo sapiens neuregulin 3 variant 5 (NRG3) mRNA, complete cds,
alternatively spliced.
ACCESSION HM068876
VERSION HM068876.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1400)
AUTHORS Kao,W.T., Wang,Y., Kleinman,J.E., Lipska,B.K., Hyde,T.M.,
Weinberger,D.R. and Law,A.J.
TITLE Common genetic variation in Neuregulin 3 (NRG3) influences risk for
schizophrenia and impacts NRG3 expression in human brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15619-15624 (2010)
PUBMED 20713722
REFERENCE 2 (bases 1 to 1400)
AUTHORS Kao,W.T.K. and Law,A.J.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2010) Clinical Brain Disorders Branch, NIMH/NIH,
10 Center Drive, Building 10, Room 3C-105, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..1400
/db_xref="H-InvDB:HIT000649170"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22"
/clone="WKCBDA37F"
/tissue_type="brain"
/dev_stage="adult"
gene 1..1400
/gene="NRG3"
CDS 30..1400
/gene="NRG3"
/note="growth factor; alternatively spliced"
/codon_start=1
/product="neuregulin 3 variant 5"
/protein_id="ADK90023.1"
/translation="MRWERRGTTHDTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIE
TLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISC
IIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHV
QLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQR
SGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPI
QLWCVERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSV
PIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLE
TVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQR
DSALTK"
BASE COUNT 436 a 329 c 329 g 306 t
ORIGIN
1 atggagtgtg gtatacctcc aacccttgta tgcgttggga gaggaggggg actacacacg
61 atacgacgac atattccaca gagcgatccg agcacttcaa accctgccga gacaaggacc
121 ttgcatactg tctcaatgat ggcgagtgct ttgtgatcga aaccctgacc ggatcccata
181 aacactgtcg gtgcaaagaa ggctaccaag gagtccgttg tgatcaattt ctgccgaaaa
241 ctgattccat cttatcggat ccaacagacc acttggggat tgaattcatg gagagtgaag
301 aagtttatca aaggcaggtg ctgtcaattt catgtatcat ctttggaatt gtcatcgtgg
361 gcatgttctg tgcagcattc tacttcaaaa gcaagaaaca agctaaacaa atccaagagc
421 agctgaaagt gccacaaaat ggtaaaagct acagtctcaa agcatccagc acaatggcaa
481 agtcagagaa cttggtgaag agccatgtcc agctgcaaaa ttattcaaag gtggaaaggc
541 atcctgtgac tgcattggag aaaatgatgg agtcaagttt tgtcggcccc cagtcattcc
601 ctgaggtccc ttctcctgac agaggaagcc agtctgtcaa acaccacagg agtctatcct
661 cttgctgcag cccagggcaa agaagtggca tgctccatag gaatgccttc agaaggacac
721 ccccgtcacc ccgaagtagg ctaggtggaa ttgtgggacc agcatatcag caactcgaag
781 aatcaaggat cccagaccag gatacgatac cttgccaagg gatagaggtc aggaagacta
841 tatcccacct gcctatacag ctgtggtgtg ttgaaagacc cctggactta aagtattcat
901 ccagtggttt aaaaacccaa cgaaatacat caataaatat gcaactgcct tcaagagaga
961 caaaccccta ttttaatagc ttggagcaaa aggacctggt gggctattca tccacaaggg
1021 ccagttctgt gcccatcatc ccttcagtgg gtttagagga aacctgcctg caaatgccag
1081 ggatttctga agtcaaaagc atcaaatggt gcaaaaactc ctattcagct gacgttgtca
1141 atgtgagtat tccagtcagc gattgtctta tagcagaaca acaagaagtg aaaatattgc
1201 tagaaactgt ccaggagcag atccgaattc tgactgatgc cagacggtca gaagactacg
1261 aactggccag cgtagaaacc gaggacagtg caagcgaaaa cacagccttt ctccccctga
1321 gtcccacagc caaatcagaa cgagaggcgc aatttgtctt aagaaatgaa atacaaagag
1381 actctgcatt gaccaagtga
//