LOCUS HM068875 1428 bp mRNA linear HUM 03-SEP-2010
DEFINITION Homo sapiens neuregulin 3 variant 4 (NRG3) mRNA, complete cds,
alternatively spliced.
ACCESSION HM068875
VERSION HM068875.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1428)
AUTHORS Kao,W.T., Wang,Y., Kleinman,J.E., Lipska,B.K., Hyde,T.M.,
Weinberger,D.R. and Law,A.J.
TITLE Common genetic variation in Neuregulin 3 (NRG3) influences risk for
schizophrenia and impacts NRG3 expression in human brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15619-15624 (2010)
PUBMED 20713722
REFERENCE 2 (bases 1 to 1428)
AUTHORS Kao,W.T.K. and Law,A.J.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2010) Clinical Brain Disorders Branch, NIMH/NIH,
10 Center Drive, Building 10, Room 3C-105, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..1428
/db_xref="H-InvDB:HIT000649169"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22"
/clone="WKCBDA03T"
/tissue_type="brain"
/dev_stage="adult"
gene 1..1428
/gene="NRG3"
CDS 1..1428
/gene="NRG3"
/note="growth factor; alternatively spliced"
/codon_start=1
/product="neuregulin 3 variant 4"
/protein_id="ADK90022.1"
/translation="MECGIPPTLVCVGRGGGLHTINIIIWYYFPSAWRTCFNISSSVG
LLLTNSYKFYTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGY
QGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAF
YFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTA
LEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPS
PRSRLGGIVGPAYQQLEESRIPDQDTIPCQGYSSSGLKTQRNTSINMQLPSRETNPYF
NSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVS
IPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLS
PTAKSEREAQFVLRNEIQRDSALTK"
BASE COUNT 440 a 331 c 329 g 328 t
ORIGIN
1 atggagtgtg gtatacctcc aacccttgta tgcgttggga gaggaggggg actacacacg
61 atcaatataa tcatctggta ttattttcct tctgcctgga ggacttgctt taacatttca
121 agtagtgtgg gtctgctgct gacgaattca tacaaatttt atacgacgac atattccaca
181 gagcgatccg agcacttcaa accctgccga gacaaggacc ttgcatactg tctcaatgat
241 ggcgagtgct ttgtgatcga aaccctgacc ggatcccata aacactgtcg gtgcaaagaa
301 ggctaccaag gagtccgttg tgatcaattt ctgccgaaaa ctgattccat cttatcggat
361 ccaacagacc acttggggat tgaattcatg gagagtgaag aagtttatca aaggcaggtg
421 ctgtcaattt catgtatcat ctttggaatt gtcatcgtgg gcatgttctg tgcagcattc
481 tacttcaaaa gcaagaaaca agctaaacaa atccaagagc agctgaaagt gccacaaaat
541 ggtaaaagct acagtctcaa agcatccagc acaatggcaa agtcagagaa cttggtgaag
601 agccatgtcc agctgcaaaa ttattcaaag gtggaaaggc atcctgtgac tgcattggag
661 aaaatgatgg agtcaagttt tgtcggcccc cagtcattcc ctgaggtccc ttctcctgac
721 agaggaagcc agtctgtcaa acaccacagg agtctatcct cttgctgcag cccagggcaa
781 agaagtggca tgctccatag gaatgccttc agaaggacac ccccgtcacc ccgaagtagg
841 ctaggtggaa ttgtgggacc agcatatcag caactcgaag aatcaaggat cccagaccag
901 gatacgatac cttgccaagg gtattcatcc agtggtttaa aaacccaacg aaatacatca
961 ataaatatgc aactgccttc aagagagaca aacccctatt ttaatagctt ggagcaaaag
1021 gacctggtgg gctattcatc cacaagggcc agttctgtgc ccatcatccc ttcagtgggt
1081 ttagaggaaa cctgcctgca aatgccaggg atttctgaag tcaaaagcat caaatggtgc
1141 aaaaactcct attcagctga cgttgtcaat gtgagtattc cagtcagcga ttgtcttata
1201 gcagaacaac aagaagtgaa aatattgcta gaaactgtcc aggagcagat ccgaattctg
1261 actgatgcca gacggtcaga agactacgaa ctggccagcg tagaaaccga ggacagtgca
1321 agcgaaaaca cagcctttct ccccctgagt cccacagcca aatcagaacg agaggcgcaa
1381 tttgtcttaa gaaatgaaat acaaagagac tctgcattga ccaagtga
//