LOCUS HM068874 1861 bp mRNA linear HUM 03-SEP-2010
DEFINITION Homo sapiens neuregulin 3 variant 3 (NRG3) mRNA, complete cds,
alternatively spliced.
ACCESSION HM068874
VERSION HM068874.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1861)
AUTHORS Kao,W.T., Wang,Y., Kleinman,J.E., Lipska,B.K., Hyde,T.M.,
Weinberger,D.R. and Law,A.J.
TITLE Common genetic variation in Neuregulin 3 (NRG3) influences risk for
schizophrenia and impacts NRG3 expression in human brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15619-15624 (2010)
PUBMED 20713722
REFERENCE 2 (bases 1 to 1861)
AUTHORS Kao,W.T.K. and Law,A.J.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2010) Clinical Brain Disorders Branch, NIMH/NIH,
10 Center Drive, Building 10, Room 3C-105, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..1861
/db_xref="H-InvDB:HIT000649168"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22"
/clone="WKCBD49F"
/tissue_type="brain"
/dev_stage="adult"
gene 1..1861
/gene="NRG3"
CDS 1..1137
/gene="NRG3"
/note="growth factor; alternatively spliced"
/codon_start=1
/product="neuregulin 3 variant 3"
/protein_id="ADK90021.1"
/translation="MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEG
AAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDL
VDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTT
ITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPST
QAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHT
TTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPK
TDSILSDPTDHLGIEFMVFKGGKASCDCIGENDGVKFCRPPVIP"
BASE COUNT 447 a 589 c 463 g 362 t
ORIGIN
1 atgagtgaag gggcagccgc tgcctcgcca cctggtgccg cttcggcagc cgccgcctcg
61 gccgaggagg gcaccgcggc ggctgcggcg gcggcagcgg cgggcggggg cccggacggc
121 ggcggcgaag gggcggccga gcccccccgg gagttacgct gtagcgactg catcgtgtgg
181 aaccggcagc agacgtggct gtgcgtggta cctctgttca tcggcttcat cggcctgggg
241 ctcagcctca tgcttctcaa atggatcgtg gtgggctccg tcaaggagta cgtgcccacc
301 gacctagtgg actccaaggg gatgggccag gaccccttct tcctctccaa gcccagctct
361 ttccccaagg ccatggagac caccaccact accacttcca ccacgtcccc cgccaccccc
421 tccgccgggg gtgccgcctc ctccaggacg cccaaccgga ttagcactcg cctgaccacc
481 atcacgcggg cgcccactcg cttccccggg caccgggtgc ccatccgggc cagcccgcgc
541 tccaccacag cacggaacac tgcggcccct gcgacggtcc cgtccaccac ggccccgttc
601 ttcagtagca gcacgctggg ctcccgaccc ccggtgccag gaactccaag tacccaggca
661 atgccctcct ggcctactgc ggcatacgct acctcctcct accttcacga ttctactccc
721 tcctggaccc tgtctccctt tcaggatgct gcctcctctt cttcctcttc ttcctcctcc
781 gctaccacca ccacaccaga aactagcacc agccccaaat ttcatacgac gacatattcc
841 acagagcgat ccgagcactt caaaccctgc cgagacaagg accttgcata ctgtctcaat
901 gatggcgagt gctttgtgat cgaaaccctg accggatccc ataaacactg tcggtgcaaa
961 gaaggctacc aaggagtccg ttgtgatcaa tttctgccga aaactgattc catcttatcg
1021 gatccaacag accacttggg gattgaattc atggtattca aaggtggaaa ggcatcctgt
1081 gactgcattg gagaaaatga tggagtcaag ttttgtcggc ccccagtcat tccctgaggt
1141 cccttctcct gacagaggaa gccagtctgt caaacaccac aggagtctat cctcttgctg
1201 cagcccaggg caaagaagtg gcatgctcca taggaatgcc ttcagaagga cacccccgtc
1261 accccgaagt aggctaggtg gaattgtggg accagcatat cagcaactcg aagaatcaag
1321 gatcccagac caggatacga taccttgcca agggtattca tccagtggtt taaaaaccca
1381 acgaaataca tcaataaata tgcaactgcc ttcaagagag acaaacccct attttaatag
1441 cttggagcaa aaggacctgg tgggctattc atccacaagg gccagttctg tgcccatcat
1501 cccttcagtg ggtttagagg aaacctgcct gcaaatgcca gggatttctg aagtcaaaag
1561 catcaaatgg tgcaaaaact cctattcagc tgacgttgtc aatgtgagta ttccagtcag
1621 cgattgtctt atagcagaac aacaagaagt gaaaatattg ctagaaactg tccaggagca
1681 gatccgaatt ctgactgatg ccagacggtc agaagactac gaactggcca gcgtagaaac
1741 cgaggacagt gcaagcgaaa acacagcctt tctccccctg agtcccacag ccaaatcaga
1801 acgagaggcg caatttgtct taagaaatga aatacaaaga gactctgcat tgaccaagtg
1861 a
//