LOCUS HM068873 2163 bp mRNA linear HUM 03-SEP-2010
DEFINITION Homo sapiens neuregulin 3 variant 1 (NRG3) mRNA, complete cds,
alternatively spliced.
ACCESSION HM068873
VERSION HM068873.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2163)
AUTHORS Kao,W.T., Wang,Y., Kleinman,J.E., Lipska,B.K., Hyde,T.M.,
Weinberger,D.R. and Law,A.J.
TITLE Common genetic variation in Neuregulin 3 (NRG3) influences risk for
schizophrenia and impacts NRG3 expression in human brain
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 107 (35), 15619-15624 (2010)
PUBMED 20713722
REFERENCE 2 (bases 1 to 2163)
AUTHORS Kao,W.T.K. and Law,A.J.
TITLE Direct Submission
JOURNAL Submitted (08-APR-2010) Clinical Brain Disorders Branch, NIMH/NIH,
10 Center Drive, Building 10, Room 3C-105, Bethesda, MD 20892, USA
FEATURES Location/Qualifiers
source 1..2163
/db_xref="H-InvDB:HIT000649167"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="10"
/map="10q22"
/clone="WKCBDA21F"
/tissue_type="brain"
/dev_stage="adult"
gene 1..2163
/gene="NRG3"
CDS 1..2163
/gene="NRG3"
/note="growth factor; alternatively spliced"
/codon_start=1
/product="neuregulin 3 variant 1"
/protein_id="ADK90020.1"
/translation="MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEG
AAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDL
VDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTT
ITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPST
QAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHT
TTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPK
TDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQI
QEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVG
PQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGP
AYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSI
NMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKW
CKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETE
DSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK"
BASE COUNT 550 a 650 c 532 g 431 t
ORIGIN
1 atgagtgaag gggcagccgc tgcctcgcca cctggtgccg cttcggcagc cgccgcctcg
61 gccgaggagg gcaccgcggc ggctgcggcg gcggcagcgg cgggcggggg cccggacggc
121 ggcggcgaag gggcggccga gcccccccgg gagttacgct gtagcgactg catcgtgtgg
181 aaccggcagc agacgtggct gtgcgtggta cctctgttca tcggcttcat cggcctgggg
241 ctcagcctca tgcttctcaa atggatcgtg gtgggctccg tcaaggagta cgtgcccacc
301 gacctagtgg actccaaggg gatgggccag gaccccttct tcctctccaa gcccagctct
361 ttccccaagg ccatggagac caccaccact accacttcca ccacgtcccc cgccaccccc
421 tccgccgggg gtgccgcctc ctccaggacg cccaaccgga ttagcactcg cctgaccacc
481 atcacgcggg cgcccactcg cttccccggg caccgggtgc ccatccgggc cagcccgcgc
541 tccaccacag cacggaacac tgcggcccct gcgacggtcc cgtccaccac ggccccgttc
601 ttcagtagca gcacgctggg ctcccgaccc ccggtgccag gaactccaag tacccaggca
661 atgccctcct ggcctactgc ggcatacgct acctcctcct accttcacga ttctactccc
721 tcctggaccc tgtctccctt tcaggatgct gcctcctctt cttcctcttc ttcctcctcc
781 gctaccacca ccacaccaga aactagcacc agccccaaat ttcatacgac gacatattcc
841 acagagcgat ccgagcactt caaaccctgc cgagacaagg accttgcata ctgtctcaat
901 gatggcgagt gctttgtgat cgaaaccctg accggatccc ataaacactg tcggtgcaaa
961 gaaggctacc aaggagtccg ttgtgatcaa tttctgccga aaactgattc catcttatcg
1021 gatccaacag accacttggg gattgaattc atggagagtg aagaagttta tcaaaggcag
1081 gtgctgtcaa tttcatgtat catctttgga attgtcatcg tgggcatgtt ctgtgcagca
1141 ttctacttca aaagcaagaa acaagctaaa caaatccaag agcagctgaa agtgccacaa
1201 aatggtaaaa gctacagtct caaagcatcc agcacaatgg caaagtcaga gaacttggtg
1261 aagagccatg tccagctgca aaattattca aaggtggaaa ggcatcctgt gactgcattg
1321 gagaaaatga tggagtcaag ttttgtcggc ccccagtcat tccctgaggt cccttctcct
1381 gacagaggaa gccagtctgt caaacaccac aggagtctat cctcttgctg cagcccaggg
1441 caaagaagtg gcatgctcca taggaatgcc ttcagaagga cacccccgtc accccgaagt
1501 aggctaggtg gaattgtggg accagcatat cagcaactcg aagaatcaag gatcccagac
1561 caggatacga taccttgcca agggatagag gtcaggaaga ctatatccca cctgcctata
1621 cagctgtggt gtgttgaaag acccctggac ttaaagtatt catccagtgg tttaaaaacc
1681 caacgaaata catcaataaa tatgcaactg ccttcaagag agacaaaccc ctattttaat
1741 agcttggagc aaaaggacct ggtgggctat tcatccacaa gggccagttc tgtgcccatc
1801 atcccttcag tgggtttaga ggaaacctgc ctgcaaatgc cagggatttc tgaagtcaaa
1861 agcatcaaat ggtgcaaaaa ctcctattca gctgacgttg tcaatgtgag tattccagtc
1921 agcgattgtc ttatagcaga acaacaagaa gtgaaaatat tgctagaaac tgtccaggag
1981 cagatccgaa ttctgactga tgccagacgg tcagaagact acgaactggc cagcgtagaa
2041 accgaggaca gtgcaagcga aaacacagcc tttctccccc tgagtcccac agccaaatca
2101 gaacgagagg cgcaatttgt cttaagaaat gaaatacaaa gagactctgc attgaccaag
2161 tga
//