LOCUS       FJ785401                 647 bp    mRNA    linear   HUM 24-JUL-2016
DEFINITION  Homo sapiens isolate RRC2008 mutant BCR/ABL fusion protein mRNA,
            partial cds.
ACCESSION   FJ785401
VERSION     FJ785401.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 647)
  AUTHORS   Hokama,P.O., Capannacci,J., Hokama,N.K., Cliquet,M.G., Souza,M.P.,
            Mauad,M.A. and Colturato,V.A.
  TITLE     Description of a new BCR-ABL point mutation in a CML patient with
            evolution to lymphoid blast crisis
  JOURNAL   Leuk. Res. 34 (4), E106-E107 (2010)
   PUBMED   19931180
REFERENCE   2  (bases 1 to 647)
  AUTHORS   Hokama,P.O.M., Capannacci,J., Hokama,N.K., Bertoluci,B.,
            Souza,M.P., Cliquet,M., Mauad,M. and Colturato,V.A.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-FEB-2009) Molecular Biology Laboratory, Amaral
            Carvalho Hospital - Bone Marrow Transplantation Service, Rua Dona
            Silveria, 150, Jau, Sao Paulo 17210-080, Brasil
FEATURES             Location/Qualifiers
     source          1..647
                     /db_xref="H-InvDB:HIT000558916"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="RRC2008"
                     /isolation_source="CML patient with lymphoid blast crisis"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34"
     CDS             <1..>647
                     /note="ABL kinase domain"
                     /codon_start=3
                     /product="mutant BCR/ABL fusion protein"
                     /protein_id="ACN82441.1"
                     /translation="YEGVWKKYGLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
                     LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN
                     FIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKF
                     SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYEL"
     variation       27
                     /note="S265G"
                     /replace="a"
BASE COUNT          162 a          165 c          188 g          132 t
ORIGIN      
        1 tgtacgaggg cgtgtggaag aaatacggcc tgacggtggc cgtgaagacc ttgaaggagg
       61 acaccatgga ggtggaagag ttcttgaaag aagctgcagt catgaaagag atcaaacacc
      121 ctaacctggt gcagctcctt ggggtctgca cccgggagcc cccgttctat atcatcactg
      181 agttcatgac ctacgggaac ctcctggact acctgaggga gtgcaaccgg caggaggtga
      241 acgccgtggt gctgctgtac atggccactc agatctcgtc agccatggag tacctggaga
      301 agaaaaactt catccacaga gatcttgctg cccgaaactg cctggtaggg gagaaccact
      361 tggtgaaggt agctgatttt ggcctgagca ggttgatgac aggggacacc tacacagccc
      421 atgctggagc caagttcccc atcaaatgga ctgcacccga gagcctggcc tacaacaagt
      481 tctccatcaa gtccgacgtc tgggcatttg gagtattgct ttgggaaatt gctacctatg
      541 gcatgtcccc ttacccggga attgacctgt cccaggtgta tgagctgcta gagaaggact
      601 accgcatgga gcgcccagaa ggctgcccag agaaggtcta tgaactc
//