LOCUS FJ481111 3999 bp mRNA linear HUM 10-JAN-2009
DEFINITION Homo sapiens NPC1-like 1 protein (NPC11L1) mRNA, complete cds.
ACCESSION FJ481111
VERSION FJ481111.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3999)
AUTHORS Wang,J., Chu,B.-B., Ge,L. and Song,B.-L.
TITLE Membrane Topology of Human NPC1L1, a Protein that Plays a Key Role
in Enterohepatic Cholesterol Absorption
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3999)
AUTHORS Song,B.-L., Ge,L., Wang,J. and Wang,J.
TITLE Direct Submission
JOURNAL Submitted (22-NOV-2008) Molecular Biology, Institute of
Biochemistry and Cell Biology, No. 320 Yue Yang Road, Shanghai,
Shanghai 086-20031, China
FEATURES Location/Qualifiers
source 1..3999
/db_xref="H-InvDB:HIT000558634"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_type="hepatocytes"
gene 1..3999
/gene="NPC11L1"
CDS 1..3999
/gene="NPC11L1"
/note="cholesterol transporter; Niemann-Pick disease type
C1; multitransmembrane protein that plays a key role in
cholesterol absorption in the instestine and liver"
/codon_start=1
/product="NPC1-like 1 protein"
/protein_id="ACL18055.1"
/translation="MAEAGLRGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPE
LSGSLMTLSNVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEAS
LSITKALLTRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLPAVVAYEAFY
QHSFAEQSYDSCSRVRVPAAATLAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDI
TFHLLEPGQAVGSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQALDSTF
YLGQMPGSLVLIIILCSVFAVVTILLVGFRVAPARDKSKMVDPKKGTSLSDKLSFSTH
TLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARS
EKAFHDQHFGPFFRTNQVILTAPNRSSYRYDSLLLGPKNFSGILDLDLLLELLELQER
LRHLQVWSPEAQRNISLQDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQT
LMGQTSQVDWKDHFLYCANAPLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSE
AEALIMTFSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDE
INRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMA
AMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREVHIGRAL
GRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLD
SKRQEASRLDVCCCVKPQELPPPGQGEGLLLGFFQKAYAPFLLHWITRGVVLLLFLAL
FGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEA
GMNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSSCCRLYIS
GPNKDKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLA
AYSTSVNLTSDGQVLASRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDP
AFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIV
MILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEA
TISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVIL
SYVGPDVNPALALEQKRAEEAVAAVMVASCPNHPSRVSTADNIYVNHSFEGSIKGAGA
ISNFLPNNGRQF"
misc_feature 859..912
/gene="NPC11L1"
/note="TMhelix-1; transmembrane region"
misc_feature 1057..1107
/gene="NPC11L1"
/note="TMhelix-2; transmembrane region"
misc_feature 1897..1953
/gene="NPC11L1"
/note="TMhelix-3; transmembrane region"
misc_feature 2002..2049
/gene="NPC11L1"
/note="TMhelix-4; transmembrane region"
misc_feature 2086..2133
/gene="NPC11L1"
/note="TMhelix-5; transmembrane region"
misc_feature 2233..2289
/gene="NPC11L1"
/note="TMhelix-6; transmembrane region"
misc_feature 2335..2391
/gene="NPC11L1"
/note="TMhelix-7; transmembrane region"
misc_feature 2539..2583
/gene="NPC11L1"
/note="TMhelix-8; transmembrane region"
misc_feature 3334..3399
/gene="NPC11L1"
/note="TMhelix-9; transmembrane region"
misc_feature 3406..3462
/gene="NPC11L1"
/note="TMhelix-10; transmembrane region"
misc_feature 3511..3558
/gene="NPC11L1"
/note="TMhelix-11; transmembrane region"
misc_feature 3610..3690
/gene="NPC11L1"
/note="TMhelix-12; transmembrane region"
misc_feature 3724..3780
/gene="NPC11L1"
/note="TMhelix-13; transmembrane region"
variation 816
/gene="NPC11L1"
/note="compared to NM_001101648.1"
/replace="c"
variation 2029
/gene="NPC11L1"
/note="compared to NM_001101648.1"
/replace="c"
variation 3792
/gene="NPC11L1"
/note="compared to NM_001101648.1"
/replace="c"
variation 3807
/gene="NPC11L1"
/note="compared to NM_001101648.1"
/replace="t"
BASE COUNT 722 a 1314 c 1059 g 904 t
ORIGIN
1 atggcggagg ccggcctgag gggctggctg ctgtgggccc tgctcctgcg cttggcccag
61 agtgagcctt acacaaccat ccaccagcct ggctactgcg ccttctatga cgaatgtggg
121 aagaacccag agctgtctgg aagcctcatg acactctcca acgtgtcctg cctgtccaac
181 acgccggccc gcaagatcac aggtgatcac ctgatcctat tacagaagat ctgcccccgc
241 ctctacaccg gccccaacac ccaagcctgc tgctccgcca agcagctggt atcactggaa
301 gcgagtctgt cgatcaccaa ggccctcctc acccgctgcc cagcctgctc tgacaatttt
361 gtgaacctgc actgccacaa cacgtgcagc cccaatcaga gcctcttcat caatgtgacc
421 cgcgtggccc agctaggggc tggacaactc ccagctgtgg tggcctatga ggccttctac
481 cagcatagct ttgccgagca gagctatgac tcctgcagcc gtgtgcgcgt ccctgcagct
541 gccacgctgg ctgtgggcac catgtgtggc gtgtatggct ctgccctttg caatgcccag
601 cgctggctca acttccaggg agacacaggc aatggtctgg ccccactgga catcaccttc
661 cacctcttgg agcctggcca ggccgtgggg agtgggattc agcctctgaa tgagggggtt
721 gcacgttgca atgagtccca aggtgacgac gtggcgacct gctcctgcca agactgtgct
781 gcatcctgtc ctgccatagc ccgcccccag gccctggact ccaccttcta cctgggccag
841 atgccgggca gtctggtcct catcatcatc ctctgctctg tcttcgctgt ggtcaccatc
901 ctgcttgtgg gattccgtgt ggcccccgcc agggacaaaa gcaagatggt ggaccccaag
961 aagggcacca gcctctctga caagctcagc ttctccaccc acaccctcct tggccagttc
1021 ttccagggct ggggcacgtg ggtggcttcg tggcctctga ccatcttggt gctatctgtc
1081 atcccggtgg tggccttggc agcgggcctg gtctttacag aactcactac ggaccccgtg
1141 gagctgtggt cggcccccaa cagccaagcc cggagtgaga aagctttcca tgaccagcat
1201 ttcggcccct tcttccgaac caaccaggtg atcctgacgg ctcctaaccg gtccagctac
1261 aggtatgact ctctgctgct ggggcccaag aacttcagcg gaatcctgga cctggacttg
1321 ctgctggagc tgctagagct gcaggagagg ctgcggcacc tccaggtatg gtcgcccgaa
1381 gcacagcgca acatctccct gcaggacatc tgctacgccc ccctcaatcc ggacaatacc
1441 agtctctacg actgctgcat caacagcctc ctgcagtatt tccagaacaa ccgcacgctc
1501 ctgctgctca cagccaacca gacactgatg gggcagacct cccaagtcga ctggaaggac
1561 cattttctgt actgtgccaa tgccccgctc accttcaagg atggcacagc cctggccctg
1621 agctgcatgg ctgactacgg ggcccctgtc ttccccttcc ttgccattgg ggggtacaaa
1681 ggaaaggact attctgaggc agaggccctg atcatgacgt tctccctcaa caattaccct
1741 gccggggacc cccgtctggc ccaggccaag ctgtgggagg aggccttctt agaggaaatg
1801 cgagccttcc agcgtcggat ggctggcatg ttccaggtca cgttcatggc tgagcgctct
1861 ctggaagacg agatcaatcg caccacagct gaagacctgc ccatctttgc caccagctac
1921 attgtcatat tcctgtacat ctctctggcc ctgggcagct attccagctg gagccgagtg
1981 atggtggact ccaaggccac gctgggcctc ggcggggtgg ccgtggtctt gggagcagtc
2041 atggctgcca tgggcttctt ctcctacttg ggtatccgct cctccctggt catcctgcaa
2101 gtggttcctt tcctggtgct gtccgtgggg gctgataaca tcttcatctt tgttctcgag
2161 taccagaggc tgccccggag gcctggggag ccacgagagg tccacattgg gcgagcccta
2221 ggcagggtgg ctcccagcat gctgttgtgc agcctctctg aggccatctg cttcttccta
2281 ggggccctga cccccatgcc agctgtgcgg acctttgccc tgacctctgg ccttgcagtg
2341 atccttgact tcctcctgca gatgtcagcc tttgtggccc tgctctccct ggacagcaag
2401 aggcaggagg cctcccggtt ggacgtctgc tgctgtgtca agccccagga gctgcccccg
2461 cctggccagg gagaggggct cctgcttggc ttcttccaaa aggcttatgc ccccttcctg
2521 ctgcactgga tcactcgagg tgttgtgctg ctgctgtttc tcgccctgtt cggagtgagc
2581 ctctactcca tgtgccacat cagcgtggga ctggaccagg agctggccct gcccaaggac
2641 tcgtacctgc ttgactattt cctctttctg aaccgctact tcgaggtggg ggccccggtg
2701 tactttgtta ccaccttggg ctacaacttc tccagcgagg ctgggatgaa tgccatctgc
2761 tccagtgcag gctgcaacaa cttctccttc acccagaaga tccagtatgc cacagagttc
2821 cctgagcagt cttacctggc catccctgcc tcctcctggg tggatgactt cattgactgg
2881 ctgaccccgt cctcctgctg ccgcctttat atatctggcc ccaataagga caagttctgc
2941 ccctcgaccg tcaactctct gaactgccta aagaactgca tgagcatcac gatgggctct
3001 gtgaggccct cggtggagca gttccataag tatcttccct ggttcctgaa cgaccggccc
3061 aacatcaaat gtcccaaagg cggcctggca gcatacagca cctctgtgaa cttgacttca
3121 gatggccagg ttttagcctc caggttcatg gcctatcaca agcccctgaa aaactcacag
3181 gattacacag aagctctgcg ggcagctcga gagctggcag ccaacatcac tgctgacctg
3241 cggaaagtgc ctggaacaga cccggctttt gaggtcttcc cctacacgat caccaatgtg
3301 ttttatgagc agtacctgac catcctccct gaggggctct tcatgctcag cctctgcctt
3361 gtgcccacct tcgctgtctc ctgcctcctg ctgggcctgg acctgcgctc cggcctcctc
3421 aacctgctct ccattgtcat gatcctcgtg gacactgtcg gcttcatggc cctgtggggc
3481 atcagttaca atgctgtgtc cctcatcaac ctggtctcgg cggtgggcat gtctgtggag
3541 tttgtgtccc acattacccg ctcctttgcc atcagcacca agcccacctg gctggagagg
3601 gccaaagagg ccaccatctc tatgggaagt gcggtgtttg caggtgtggc catgaccaac
3661 ctgcctggca tccttgtcct gggcctcgcc aaggcccagc tcattcagat cttcttcttc
3721 cgcctcaacc tcctgatcac tctgctgggc ctgctgcatg gcttggtctt cctgcccgtc
3781 atcctcagct atgtggggcc tgacgtcaac ccggctctgg cactggagca gaagcgggct
3841 gaggaggcgg tggcagcagt catggtggcc tcttgcccaa atcacccctc ccgagtctcc
3901 acagctgaca acatctatgt caaccacagc tttgaaggtt ctatcaaagg tgctggtgcc
3961 atcagcaact tcttgcccaa caatgggcgg cagttctga
//