LOCUS EU978942 1733 bp mRNA linear HUM 15-SEP-2008
DEFINITION Homo sapiens K2P13.1 potassium channel (KCNK13) mRNA, complete cds.
ACCESSION EU978942
VERSION EU978942.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1733)
AUTHORS Gierten,J., Ficker,E., Bloehs,R., Schlomer,K., Kathofer,S.,
Scholz,E., Zitron,E., Kiesecker,C., Bauer,A., Becker,R.,
Katus,H.A., Karle,C.A. and Thomas,D.
TITLE Regulation of two-pore-domain (K2P) potassium leak channels by the
tyrosine kinase inhibitor genistein
JOURNAL Br. J. Pharmacol. 154 (8), 1680-1690 (2008)
PUBMED 18516069
REFERENCE 2 (bases 1 to 1733)
AUTHORS Thomas,D.
TITLE Direct Submission
JOURNAL Submitted (04-AUG-2008) Department of Cardiology, Medical
University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..1733
/db_xref="H-InvDB:HIT000558385"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
gene 1..1733
/gene="KCNK13"
/gene_synonym="THIK-1"
/gene_synonym="THIK1"
CDS 184..1410
/gene="KCNK13"
/gene_synonym="THIK-1"
/gene_synonym="THIK1"
/note="two-pore-domain potassium channel subunit; tandem
pore domain halothane inhibited K+ channel; potassium
channel subfamily K member 13"
/codon_start=1
/product="K2P13.1 potassium channel"
/protein_id="ACH86101.1"
/translation="MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELA
HERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEEATRAGIRVDNVRPRWDFTGAFY
FVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSC
HQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTP
IEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLF
NVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVRNRCNISIETDGVAE
SDTDGRRLSGEMISMKDLLAANKASLAILQKQLSEMANGCPHQTSTLARDNEFSGGVG
AFAIMNNRLAETSGDR"
BASE COUNT 325 a 526 c 530 g 352 t
ORIGIN
1 ctaccgaggc ggcggccggg ggagcctcgc ggcctgcggg agagcccggc ggtcatgggc
61 gagccggcgg tggggcgccc gggagctggc tgagcgccgg ggcccttatt tcccgggggt
121 gtgggcgaga ctccgccgac gcccggtgcc gtgggcctgg gggctgcccc cgggggcccg
181 gccatggctg gccggggttt cagctggggc ccgggccacc tgaacgagga caacgcgcgc
241 tttctgctgc tggccgcgct catcgtgctc tacctgctgg gcggcgccgc cgtcttctcc
301 gcgctggagc tggcgcacga gcgccaggcc aagcagcgct gggaggagcg cctggccaac
361 ttcagccgcg gccacaacct gagccgcgac gagctgcgcg gcttcctccg ccactacgag
421 gaggccactc gggccggcat ccgcgtggac aacgtccgcc cgcgctggga cttcaccggc
481 gccttctact tcgtgggcac cgtcgtttcc accatagggt ttgggatgac aactccggcg
541 acagtaggag gaaaaatctt tctgatcttt tacggccttg ttgggtgttc cagcaccatc
601 ttgttcttca acctcttcct ggagcgcctg atcaccatca tcgcctacat catgaagtcg
661 tgccaccagc ggcagctccg gagacgaggg gccctgcccc aggagagcct gaaggatgcg
721 gggcagtgtg aggtggacag cctggccggc tggaagccct ccgtgtacta cgtcatgctg
781 atcctatgca cagcctccat cctcatctct tgctgcgcct cagccatgta cacccccatt
841 gaaggctgga gctactttga ctcactctac ttctgttttg tggctttcag caccattggc
901 tttggggacc tggtcagcag ccagaacgcc cactatgaga gccaaggcct ctatcgcttt
961 gccaacttcg tcttcatcct catgggtgtc tgctgcatct actccttgtt caatgtcatc
1021 tctatcctca tcaaacagtc cttgaactgg atcctgagga aaatggacag cgggtgctgc
1081 ccgcaatgcc agagaggact cttgcgatca cgcaggaacg tggtgatgcc aggcagcgtc
1141 cggaaccgct gcaacatctc catagagaca gacggggtgg cagagagtga cacggacggg
1201 cgccggctct caggggagat gatctccatg aaggacttgc tggcagccaa caaggcctcg
1261 ttggccatcc tgcagaagca actgtctgag atggccaacg gctgccccca ccagaccagc
1321 acactggccc gggacaatga attctcaggg ggggtgggag cctttgcaat catgaacaac
1381 aggttggcag agaccagtgg ggacaggtag aagccaggag tggatgctgg gcagaggcca
1441 gagtagaatg gaggatgatt gccgcccagg ggacgagctc agccctgcgc cttggctctg
1501 ttccttctgg gagctgttcc cgggagcctc cgcaagcatc tttagaaatc tgatctcggc
1561 tccaaccaac agccaccttc cagggatggg gggcctgaag cctcgatgct tgtctcctga
1621 tccttattct ttaagtctaa attcagtctt ttcaaaacaa atcacaaaag cagcattaga
1681 cattgccttg tttcattaat cttgtttcag agctttagct gcctgaggag ata
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