LOCUS EU978940 1966 bp mRNA linear HUM 15-SEP-2008
DEFINITION Homo sapiens K2P10.1 potassium channel isoform 3 (KCNK10) mRNA,
complete cds.
ACCESSION EU978940
VERSION EU978940.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 1966)
AUTHORS Gierten,J., Ficker,E., Bloehs,R., Schlomer,K., Kathofer,S.,
Scholz,E., Zitron,E., Kiesecker,C., Bauer,A., Becker,R.,
Katus,H.A., Karle,C.A. and Thomas,D.
TITLE Regulation of two-pore-domain (K2P) potassium leak channels by the
tyrosine kinase inhibitor genistein
JOURNAL Br. J. Pharmacol. 154 (8), 1680-1690 (2008)
PUBMED 18516069
REFERENCE 2 (bases 1 to 1966)
AUTHORS Thomas,D.
TITLE Direct Submission
JOURNAL Submitted (04-AUG-2008) Department of Cardiology, Medical
University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..1966
/db_xref="H-InvDB:HIT000558383"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="pancreas"
gene 1..1966
/gene="KCNK10"
/gene_synonym="TREK-2"
/gene_synonym="TREK2"
CDS 29..1660
/gene="KCNK10"
/gene_synonym="TREK-2"
/gene_synonym="TREK2"
/note="two-pore-domain potassium channel subunit;
TWIK-related K+ channel 2; potassium channel TREK2 splice
variant b; subfamily K member 10 transcript variant 3"
/codon_start=1
/product="K2P10.1 potassium channel isoform 3"
/protein_id="ACH86099.1"
/translation="MEDGFKGDRTEGCRSDSVAVPAAAPVCQPKSATNGQPPAPAPTP
TPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPF
ESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLG
SAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKS
IARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVV
VTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKT
KEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAH
SLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIIN
KFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAM
LTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN"
BASE COUNT 491 a 486 c 554 g 435 t
ORIGIN
1 agtgacacac catgtacatg gctggtatat ggaggatgga tttaaggggg acaggactga
61 aggctgtcgc agtgattcag tggccgttcc cgcagcagca ccggtgtgcc agcccaagag
121 cgccactaac gggcaacccc cggctccggc tccgactcca actccgcgcc tgtccatttc
181 ctcccgagcc acagtggtag ccaggatgga aggcacctcc caagggggct tgcagaccgt
241 catgaagtgg aagacggtgg ttgccatctt tgtggttgtg gtggtctacc ttgtcactgg
301 cggtcttgtc ttccgggcat tggagcagcc ctttgagagc agccagaaga ataccatcgc
361 cttggagaag gcggaattcc tgcgggatca tgtctgtgtg agcccccagg agctggagac
421 gttgatccag catgctcttg atgctgacaa tgcgggagtc agtccaatag gaaactcttc
481 caacaacagc agccactggg acctcggcag tgcctttttc tttgctggaa ctgtcattac
541 gaccataggg tatgggaata ttgctccgag cactgaagga ggcaaaatct tttgtatttt
601 atatgccatc tttggaattc cactctttgg tttcttattg gctggaattg gagaccaact
661 tggaaccatc tttgggaaaa gcattgcaag agtggagaag gtctttcgaa aaaagcaagt
721 gagtcagacc aagatccggg tcatctcaac catcctgttc atcttggccg gctgcattgt
781 gtttgtgacg atccctgctg tcatctttaa gtacatcgag ggctggacgg ccttggagtc
841 catttacttt gtggtggtca ctctgaccac ggtgggcttt ggtgattttg tggcaggggg
901 aaacgctggc atcaattatc gggagtggta taagccccta gtgtggtttt ggatccttgt
961 tggccttgcc tactttgcag ctgtcctcag tatgatcgga gattggctac gggttctgtc
1021 caaaaagaca aaagaagagg tgggtgaaat caaggcccat gcggcagagt ggaaggccaa
1081 tgtcacggct gagttccggg agacacggcg aaggctcagc gtggagatcc acgataagct
1141 gcagcgggcg gccaccatcc gcagcatgga gcgccggcgg ctgggcctgg accagcgggc
1201 ccactcactg gacatgctgt cccccgagaa gcgctctgtc tttgctgccc tggacaccgg
1261 ccgcttcaag gcctcatccc aggagagcat caacaaccgg cccaacaacc tgcgcctgaa
1321 ggggccggag cagctgaaca agcatgggca gggtgcgtcc gaggacaaca tcatcaacaa
1381 gttcgggtcc acctccagac tcaccaagag gaaaaacaag gacctcaaaa agaccttgcc
1441 cgaggacgtt cagaaaatct acaagacctt ccggaattac tccctggacg aggagaagaa
1501 agaggaggag acggaaaaga tgtgtaactc agacaactcc agcacagcca tgctgacgga
1561 ctgtatccag cagcacgctg agttggagaa cggaatgata cccacggaca ccaaagaccg
1621 ggagccggag aacaactcat tacttgaaga cagaaactaa atgtgaagga cattggtctt
1681 ggactgagcg ttgtgtgtgt gtgtgtgtgt gtttttaata ttcacactga gacatgtgcc
1741 ttaaacagac tttttagtcc aaaattacat agcattgaag aatatatttc actgtgccat
1801 aaacaactga aagcttgctc tgccaaaagg aatcagagaa caagaacttc atttcagata
1861 gcaaacgcag gacacaccaa gagtgtccgt gcacgtagcc ggttctggcc gtacatgtta
1921 agggcatttc agtggcagtg ctgtacccct gggcagtgct acctgg
//