LOCUS EU978938 2209 bp mRNA linear HUM 15-SEP-2008
DEFINITION Homo sapiens K2P10.1 potassium channel isoform 1 (KCNK10) mRNA,
complete cds.
ACCESSION EU978938
VERSION EU978938.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2209)
AUTHORS Gierten,J., Ficker,E., Bloehs,R., Schlomer,K., Kathofer,S.,
Scholz,E., Zitron,E., Kiesecker,C., Bauer,A., Becker,R.,
Katus,H.A., Karle,C.A. and Thomas,D.
TITLE Regulation of two-pore-domain (K2P) potassium leak channels by the
tyrosine kinase inhibitor genistein
JOURNAL Br. J. Pharmacol. 154 (8), 1680-1690 (2008)
PUBMED 18516069
REFERENCE 2 (bases 1 to 2209)
AUTHORS Thomas,D.
TITLE Direct Submission
JOURNAL Submitted (04-AUG-2008) Department of Cardiology, Medical
University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg
D-69120, Germany
FEATURES Location/Qualifiers
source 1..2209
/db_xref="H-InvDB:HIT000558381"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/tissue_type="brain"
gene 1..2209
/gene="KCNK10"
/gene_synonym="TREK-2"
/gene_synonym="TREK2"
CDS 287..1903
/gene="KCNK10"
/gene_synonym="TREK-2"
/gene_synonym="TREK2"
/note="two-pore-domain potassium channel subunit;
TWIK-related K+ channel 2; potassium channel TREK2 splice
variant a; potassium channel subfamily K member 10
transcript variant 1"
/codon_start=1
/product="K2P10.1 potassium channel isoform 1"
/protein_id="ACH86097.1"
/translation="MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLS
ISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQK
NTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFF
AGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVE
KVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTT
VGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVG
EIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDML
SPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGST
SRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCI
QQHAELENGMIPTDTKDREPENNSLLEDRN"
BASE COUNT 523 a 569 c 625 g 492 t
ORIGIN
1 gcaactattg gtgcgctccg gccgggcagg ttttgagctg cagagacccg tgcccggtag
61 cagcgctttg ccaccgagtg cacccaggac gcagtggccg ccagcccggg tctcctgctg
121 ggggccggcg agtgcaggga gactttgcgc cacgatgttt tgttttcctg ccgcaggaac
181 gctaggcagt ctctttccac cggacttaac ccgcctgaag caatagccat ggaagttgcg
241 gcggcacaga gggagacaga accgcttggc gcggcatctt tcttggatgt tttttctcta
301 cacagacttc tttctttcct tggtggccgt tcccgcagca gcaccggtgt gccagcccaa
361 gagcgccact aacgggcaac ccccggctcc ggctccgact ccaactccgc gcctgtccat
421 ttcctcccga gccacagtgg tagccaggat ggaaggcacc tcccaagggg gcttgcagac
481 cgtcatgaag tggaagacgg tggttgccat ctttgtggtt gtggtggtct accttgtcac
541 tggcggtctt gtcttccggg cattggagca gccctttgag agcagccaga agaataccat
601 cgccttggag aaggcggaat tcctgcggga tcatgtctgt gtgagccccc aggagctgga
661 gacgttgatc cagcatgctc ttgatgctga caatgcggga gtcagtccaa taggaaactc
721 ttccaacaac agcagccact gggacctcgg cagtgccttt ttctttgctg gaactgtcat
781 tacgaccata gggtatggga atattgctcc gagcactgaa ggaggcaaaa tcttttgtat
841 tttatatgcc atctttggaa ttccactctt tggtttctta ttggctggaa ttggagacca
901 acttggaacc atctttggga aaagcattgc aagagtggag aaggtctttc gaaaaaagca
961 agtgagtcag accaagatcc gggtcatctc aaccatcctg ttcatcttgg ccggctgcat
1021 tgtgtttgtg acgatccctg ctgtcatctt taagtacatc gagggctgga cggccttgga
1081 gtccatttac tttgtggtgg tcactctgac cacggtgggc tttggtgatt ttgtggcagg
1141 gggaaacgct ggcatcaatt atcgggagtg gtataagccc ctagtgtggt tttggatcct
1201 tgttggcctt gcctactttg cagctgtcct cagtatgatc ggagattggc tacgggttct
1261 gtccaaaaag acaaaagaag aggtgggtga aatcaaggcc catgcggcag agtggaaggc
1321 caatgtcacg gctgagttcc gggagacacg gcgaaggctc agcgtggaga tccacgataa
1381 gctgcagcgg gcggccacca tccgcagcat ggagcgccgg cggctgggcc tggaccagcg
1441 ggcccactca ctggacatgc tgtcccccga gaagcgctct gtctttgctg ccctggacac
1501 cggccgcttc aaggcctcat cccaggagag catcaacaac cggcccaaca acctgcgcct
1561 gaaggggccg gagcagctga acaagcatgg gcagggtgcg tccgaggaca acatcatcaa
1621 caagttcggg tccacctcca gactcaccaa gaggaaaaac aaggacctca aaaagacctt
1681 gcccgaggac gttcagaaaa tctacaagac cttccggaat tactccctgg acgaggagaa
1741 gaaagaggag gagacggaaa agatgtgtaa ctcagacaac tccagcacag ccatgctgac
1801 ggactgtatc cagcagcacg ctgagttgga gaacggaatg atacccacgg acaccaaaga
1861 ccgggagccg gagaacaact cattacttga agacagaaac taaatgtgaa ggacattggt
1921 cttggactga gcgttgtgtg tgtgtgtgtg tgtgttttta atattcacac tgagacatgt
1981 gccttaaaca gactttttag tccaaaatta catagcattg aagaatatat ttcactgtgc
2041 cataaacaac tgaaagcttg ctctgccaaa aggaatcaga gaacaagaac ttcatttcag
2101 atagcaaacg caggacacac caagagtgtc cgtgcacgta gccggttctg gccgtacatg
2161 ttaagggcat ttcagtggca gtgctgtacc cctgggcagt gctacctgg
//