LOCUS EU921891 2235 bp mRNA linear HUM 27-AUG-2008 DEFINITION Homo sapiens uridine monophosphate synthetase isoform F (UMPS) mRNA, complete cds. ACCESSION EU921891 VERSION EU921891.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2235) AUTHORS Griffith,M., Pugh,T.J., Tang,M.J., Asano,J.K., Ally,A., Chan,S.Y., Taylor,G., Morin,G.B., Tai,I.T. and Marra,M.A. TITLE Genomic analysis of UMPS expression and sequence reveals novel isoforms and sequence polymorphisms associated with 5-FU resistance JOURNAL Unpublished REFERENCE 2 (bases 1 to 2235) AUTHORS Griffith,M., Pugh,T.J., Tang,M.J., Asano,J.K., Ally,A., Chan,S.Y., Taylor,G., Morin,G.B., Tai,I.T. and Marra,M.A. TITLE Direct Submission JOURNAL Submitted (24-JUL-2008) Genome Sciences Centre, British Columbia Cancer Agency, BC Cancer Research Centre, 675 West 10th Avenue, 7th Floor, Vancouver, BC V5Z 1L3, Canada COMMENT Created by TOPO TA cloning. Direction is forward with respect to M13F site. PCR primers used to generate clone were 5'-CAAACAGGCAGCGCGCGACA-3' (forward) and 5'-GCTGACTTTAGCCTCTTGGTGCCC-3' (reverse). FEATURES Location/Qualifiers source 1..2235 /db_xref="H-InvDB:HIT000558355" /organism="Homo sapiens" /mol_type="mRNA" /isolation_source="colorectal cancer cell line" /db_xref="taxon:9606" /clone="RKO_2136_2" /cell_line="RKO" /PCR_primers="fwd_seq: caaacaggcagcgcgcgaca, rev_seq: gctgactttagcctcttggtgccc" gene 1..2235 /gene="UMPS" /gene_synonym="OPRT" CDS 396..1562 /gene="UMPS" /gene_synonym="OPRT" /codon_start=1 /product="uridine monophosphate synthetase isoform F" /protein_id="ACH48229.1" /translation="MLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETV EVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETV GRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKET NLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIF EDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLI AEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGD NLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV" BASE COUNT 563 a 475 c 574 g 623 t ORIGIN 1 caaacaggca gcgcgcgaca atggcggtcg ctcgtgcagc tttggggcca ttggtgacgg 61 gtctgtacga cgtgcaggct ttcaagtttg gggacttcgt gctgaagagc gggctttcct 121 cccccatcta catcgatctg cggggcatcg tgtctcgacc gcgtcttctg agtcagatgg 181 gatctctctt acgtcaccca ggctggagtg cagctctgtg atcatagctc actgcagcct 241 ggaactcctg ggcttaagag atcttcttgc ctcgggttgc agatatttta ttccaaactg 301 cccaaaatgc aggcatcagt tttgacaccg tgtgtggagt gccttataca gctttgccat 361 tggctacagt tatctgttca accaatcaaa ttccaatgct tattagaagg aaagaaacaa 421 aggattatgg aactaagcgt cttgtagaag gaactattaa tccaggagaa acctgtttaa 481 tcattgaaga tgttgtcacc agtggatcta gtgttttgga aactgttgag gttcttcaga 541 aggagggctt gaaggtcact gatgccatag tgctgttgga cagagagcag ggaggcaagg 601 acaagttgca ggcgcacggg atccgcctcc actcagtgtg tacattgtcc aaaatgctgg 661 agattctcga gcagcagaaa aaagttgatg ctgagacagt tgggagagtg aagaggttta 721 ttcaggagaa tgtctttgtg gcagcgaatc ataatggttc tcccctttct ataaaggaag 781 cacccaaaga actcagcttc ggtgcacgtg cagagctgcc caggatccac ccagttgcat 841 cgaagcttct caggcttatg caaaagaagg agaccaatct gtgtctatct gctgatgttt 901 cactggccag agagctgttg cagctagcag atgctttagg acctagtatc tgcatgctga 961 agactcatgt agatattttg aatgatttta ctctggatgt gatgaaggag ttgataactc 1021 tggcaaaatg ccatgagttc ttgatatttg aagaccggaa gtttgcagat ataggaaaca 1081 cagtgaaaaa gcagtatgaa ggaggtatct ttaaaatagc ttcctgggca gatctagtaa 1141 atgctcacgt ggtgccaggc tcaggagttg tgaaaggcct gcaagaagtg ggcctgcctt 1201 tgcatcgggg gtgcctcctt attgcggaaa tgagctccac cggctccctg gccactgggg 1261 actacactag agcagcggtt agaatggctg aggagcactc tgaatttgtt gttggtttta 1321 tttctggctc ccgagtaagc atgaaaccag aatttcttca cttgactcca ggagttcagt 1381 tggaagcagg aggagataat cttggccaac agtacaatag cccacaagaa gttattggca 1441 aacgaggttc cgatatcatc attgtaggtc gtggcataat ctcagcagct gatcgtctgg 1501 aagcagcaga gatgtacaga aaagctgctt gggaagcgta tttgagtaga cttggtgttt 1561 gagtgcttca gatacatttt tcagatacaa tgtgaagaca ttgaagatat gtggtcctcc 1621 tgaaagtcac tggctggaaa taatccaatt attcctgctt ggattcttcc acagggcctg 1681 tgtaagaatg ggttctggag ttctcatggt ctttaggaaa tattgagtaa tttgtaatca 1741 ccgcattgat actataataa gttcattctt aagcttgctt tttttgagac tggtgtttgt 1801 tagacagcca cagtcctgtc tgggttaggg tcttccacat ttgaggatcc ttcctatctc 1861 tccatgggac tagactgctt tgttattcta tttatttttt aatttttttc gagacaggat 1921 ctcactctgt tgcccaggat ggagtgcagt ggtgagatca cggctcattg cagcctcgac 1981 ctcccaggtg atcctcccac ctcagcttcc agattagctg gtgctatagg catgcaccac 2041 cacgtccatc taaatttctt tattatttgt agagatgagg tcttgccatg ttacccaggc 2101 tggtctcaac tcctgggctc aagcgatcct cctgcctcag tctctcaaag tgctgggatt 2161 acaggtgtga gccactgtgc ccagcctaat tgcagtaaga caaaaattct agggcaccaa 2221 gaggctaaag tcagc //