LOCUS EU854148 3651 bp mRNA linear HUM 05-AUG-2008
DEFINITION Homo sapiens multidrug resistance protein 1 mRNA, complete cds,
alternatively spliced.
ACCESSION EU854148
VERSION EU854148.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 3651)
AUTHORS Jiang,Y., Sun,Q., Xie,Z., Liu,F., Xu,W. and Wang,Y.
TITLE Cloning of P-glycoprotein cDNA sequence from breast cancer MCF7
cell line
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 3651)
AUTHORS Jiang,Y., Xie,Z., Liu,F., Sun,Q. and Xu,W.
TITLE Direct Submission
JOURNAL Submitted (26-JUN-2008) The Key Laboratory of Chemical Biology,
Graduate School at Shenzhen, Tsinghua University, University Town,
Xili, Nanshan, Shenzhen, Guangdong 518055, China
FEATURES Location/Qualifiers
source 1..3651
/db_xref="H-InvDB:HIT000558225"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/cell_line="MCF7/ADR"
/PCR_primers="fwd_seq: tcttcttccaagatttcacgtc, rev_seq:
cagagttcactggcgctttg"
CDS 1..3651
/note="MDR1; P-glycoprotein; alternatively spliced"
/codon_start=1
/product="multidrug resistance protein 1"
/protein_id="ACF94688.1"
/translation="MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSN
WLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTG
FFMNLEEDMTSDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPV
LGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLE
EAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLI
GAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVH
FSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQ
DIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIM
KLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA
LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQT
AGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEAL
DESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE
TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWF
DDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLL
AIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMY
AQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVF
SAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVT
FGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKV
LLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA
NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTES
EKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYF
SMVSVQAGTKRQ"
BASE COUNT 1080 a 707 c 904 g 960 t
ORIGIN
1 atggatcttg aaggggaccg caatggagga gcaaagaaga agaacttttt taaactgaac
61 aataaaagtg aaaaagataa gaaggaaaag aaaccaactg tcagtgtatt ttcaatgttt
121 cgctattcaa attggcttga caagttgtat atggtggtgg gaactttggc tgccatcatc
181 catggggctg gacttcctct catgatgctg gtgtttggag aaatgacaga tatctttgca
241 aatgcaggaa atttagaaga tctgatgtca aacatcacta atagaagtga tatcaatgat
301 acagggttct tcatgaatct ggaggaagac atgaccagtg atgtctccaa gattaatgaa
361 ggaattggtg acaaaattgg aatgttcttt cagtcaatgg caacattttt cactgggttt
421 atagtaggat ttacacgtgg ttggaagcta acccttgtga ttttggccat cagtcctgtt
481 cttggactgt cagctgctgt ctgggcaaag atactatctt catttactga taaagaactc
541 ttagcgtatg caaaagctgg agcagtagct gaagaggtct tggcagcaat tagaactgtg
601 attgcatttg gaggacaaaa gaaagaactt gaaaggtaca acaaaaattt agaagaagct
661 aaaagaattg ggataaagaa agctattaca gccaatattt ctataggtgc tgctttcctg
721 ctgatctatg catcttatgc tctggccttc tggtatggga ccaccttggt cctctcaggg
781 gaatattcta ttggacaagt actcactgta ttcttttctg tattaattgg ggcttttagt
841 gttggacagg catctccaag cattgaagca tttgcaaatg caagaggagc agcttatgaa
901 atcttcaaga taattgataa taagccaagt attgacagct attcgaagag tgggcacaaa
961 ccagataata ttaagggaaa tttggaattc agaaatgttc acttcagtta cccatctcga
1021 aaagaagtta agatcttgaa gggtctgaac ctgaaggtgc agagtgggca gacggtggcc
1081 ctggttggaa acagtggctg tgggaagagc acaacagtcc agctgatgca gaggctctat
1141 gaccccacag aggggatggt cagtgttgat ggacaggata ttaggaccat aaatgtaagg
1201 tttctacggg aaatcattgg tgtggtgagt caggaacctg tattgtttgc caccacgata
1261 gctgaaaaca ttcgctatgg ccgtgaaaat gtcaccatgg atgagattga gaaagctgtc
1321 aaggaagcca atgcctatga ctttatcatg aaactgcctc ataaatttga caccctggtt
1381 ggagagagag gggcccagtt gagtggtggg cagaagcaga ggatcgccat tgcacgtgcc
1441 ctggttcgca accccaagat cctcctgctg gatgaggcca cgtcagcctt ggacacagaa
1501 agcgaagcag tggttcaggt ggctctggat aaggccagaa aaggtcggac caccattgtg
1561 atagctcatc gtttgtctac agttcgtaat gctgacgtca tcgctggttt cgatgatgga
1621 gtcattgtgg agaaaggaaa tcatgatgaa ctcatgaaag agaaaggcat ttacttcaaa
1681 cttgtcacaa tgcagacagc aggaaatgaa gttgaattag aaaatgcagc tgatgaatcc
1741 aaaagtgaaa ttgatgcctt ggaaatgtct tcaaatgatt caagatccag tctaataaga
1801 aaaagatcaa ctcgtaggag tgtccgtgga tcacaagccc aagacagaaa gcttagtacc
1861 aaagaggctc tggatgaaag tatacctcca gtttcctttt ggaggattat gaagctaaat
1921 ttaactgaat ggccttattt tgttgttggt gtattttgtg ccattataaa tggaggcctg
1981 caaccagcat ttgcaataat attttcaaag attatagggg tttttacaag aattgatgat
2041 cctgaaacaa aacgacagaa tagtaacttg ttttcactat tgtttctagc ccttggaatt
2101 atttctttta ttacattttt ccttcagggt ttcacatttg gcaaagctgg agagatcctc
2161 accaagcggc tccgatacat ggttttccga tccatgctca gacaggatgt gagttggttt
2221 gatgacccta aaaacaccac tggagcattg actaccaggc tcgccaatga tgctgctcaa
2281 gttaaagggg ctataggttc caggcttgct gtaattaccc agaatatagc aaatcttggg
2341 acaggaataa ttatatcctt catctatggt tggcaactaa cactgttact cttagcaatt
2401 gtacccatca ttgcaatagc aggagttgtt gaaatgaaaa tgttgtctgg acaagcactg
2461 aaagataaga aagaactaga aggttctggg aagatcgcta ctgaagcaat agaaaacttc
2521 cgaaccgttg tttctttgac tcaggagcag aagtttgaac atatgtatgc tcagagtttg
2581 caggtaccat acagaaactc tttgaggaaa gcacacatct ttggaattac attttccttc
2641 acccaggcaa tgatgtattt ttcctatgct ggatgtttcc ggtttggagc ctacttggtg
2701 gcacataaac tcatgagctt tgaggatgtt ctgttagtat tttcagctgt tgtctttggt
2761 gccatggccg tggggcaagt cagttcattt gctcctgact atgccaaagc caaaatatca
2821 gcagcccaca tcatcatgat cattgaaaaa acccctttga ttgacagcta cagcacggaa
2881 ggcctaatgc cgaacacatt ggaaggaaat gtcacatttg gtgaagttgt attcaactat
2941 cccacccgac cggacatccc agtgcttcag ggactgagcc tggaggtgaa gaagggccag
3001 acgctggctc tggtgggcag cagtggctgt gggaagagca cagtggtcca gctcctggag
3061 cggttctacg accccttggc agggaaagtg ctgcttgatg gcaaagaaat aaagcgactg
3121 aatgttcagt ggctccgagc acacctgggc atcgtgtccc aggagcccat cctgtttgac
3181 tgcagcattg ctgagaacat tgcctatgga gacaacagcc gggtggtgtc acaggaagag
3241 attgtgaggg cagcaaagga ggccaacata catgccttca tcgagtcact gcctaataaa
3301 tatagcacta aagtaggaga caaaggaact cagctctctg gtggccagaa acaacgcatt
3361 gccatagctc gtgcccttgt tagacagcct catattttgc ttttggatga agccacgtca
3421 gctctggata cagaaagtga aaaggttgtc caagaagccc tggacaaagc cagagaaggc
3481 cgcacctgca ttgtgattgc tcaccgcctg tccaccatcc agaatgcaga cttaatagtg
3541 gtgtttcaga atggcagagt caaggagcat ggcacgcatc agcagctgct ggcacagaaa
3601 ggcatctatt tttcaatggt cagtgtccag gctggaacaa agcgccagtg a
//