LOCUS EU788010 6222 bp mRNA linear HUM 17-OCT-2008 DEFINITION Homo sapiens mutant R1275Q anaplastic lymphoma kinase (ALK) mRNA, complete cds. ACCESSION EU788010 VERSION EU788010.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 6222) AUTHORS Chen,Y., Takita,J., Choi,Y.L., Kato,M., Ohira,M., Sanada,M., Wang,L., Soda,M., Kikuchi,A., Igarashi,T., Nakagawara,A., Hayashi,Y., Mano,H. and Ogawa,S. TITLE Oncogenic mutations of ALK kinase in neuroblastoma JOURNAL Nature 455 (7215), 971-974 (2008) PUBMED 18923524 REFERENCE 2 (bases 1 to 6222) AUTHORS Chen,Y., Takita,J., Choi,Y.L., Kato,M., Ohira,M., Sanada,M., Wang,L., Soda,M., Kikuchi,A., Igarashi,T., Nakagawara,A., Hayashi,Y., Mano,H. and Ogawa,S. TITLE Direct Submission JOURNAL Submitted (03-JUN-2008) Pediatrics, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan FEATURES Location/Qualifiers source 1..6222 /db_xref="H-InvDB:HIT000558070" /organism="Homo sapiens" /mol_type="mRNA" /isolate="mutant R1275Q" /db_xref="taxon:9606" /tissue_type="neuroblastoma" gene 1..6222 /gene="ALK" CDS 908..5770 /gene="ALK" /codon_start=1 /product="anaplastic lymphoma kinase" /protein_id="ACI47598.1" /translation="MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPL SYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLL GPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGE AAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQ IFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEY SPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTIL SPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGR IGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQ LGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKD ARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSL VLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVA FDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVH WLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYG AAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGEN NVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTF HPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWG WETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKV MEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPH LPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTI MTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ VAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDL KSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGP GRVAKIGDFGMAQDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAI ILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEER SPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHG SRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPG ASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILK SKNSMNQPGP" BASE COUNT 1379 a 1746 c 1856 g 1241 t ORIGIN 1 gggggcggca gcggtggtag cagctggtac ctcccgccgc ctctgttcgg agggtcgcgg 61 ggcaccgagg tgctttccgg ccgccctctg gtcggccacc caaagccgcg ggcgctgatg 121 atgggtgagg agggggcggc aagatttcgg gcgcccctgc cctgaacgcc ctcagctgct 181 gccgccgggg ccgctccagt gcctgcgaac tctgaggagc cgaggcgccg gtgagagcaa 241 ggacgctgca aacttgcgca gcgcgggggc tgggattcac gcccagaagt tcagcaggca 301 gacagtccga agccttcccg cagcggagag atagcttgag ggtgcgcaag acggcagcct 361 ccgccctcgg ttcccgccca gaccgggcag aagagcttgg aggagccaaa aggaacgcaa 421 aaggcggcca ggacagcgtg cagcagctgg gagccgccgt tctcagcctt aaaagttgca 481 gagattggag gctgccccga gaggggacag accccagctc cgactgcggg gggcaggaga 541 ggacggtacc caactgccac ctcccttcaa ccatagtagt tcctctgtac cgagcgcagc 601 gagctacaga cgggggcgcg gcactcggcg cggagagcgg gaggctcaag gtcccagcca 661 gtgagcccag tgtgcttgag tgtctctgga ctcgcccctg agcttccagg tctgtttcat 721 ttagactcct gctcgcctcc gtgcagttgg gggaaagcaa gagacttgcg cgcacgcaca 781 gtcctctgga gatcaggtgg aaggagccgc tgggtaccaa ggactgttca gagcctcttc 841 ccatctcggg gagagcgaag ggtgaggctg ggcccggaga gcagtgtaaa cggcctcctc 901 cggcgggatg ggagccatcg ggctcctgtg gctcctgccg ctgctgcttt ccacggcagc 961 tgtgggctcc gggatgggga ccggccagcg cgcgggctcc ccagctgcgg ggccgccgct 1021 gcagccccgg gagccactca gctactcgcg cctgcagagg aagagtctgg cagttgactt 1081 cgtggtgccc tcgctcttcc gtgtctacgc ccgggaccta ctgctgccac catcctcctc 1141 ggagctgaag gctggcaggc ccgaggcccg cggctcgcta gctctggact gcgccccgct 1201 gctcaggttg ctggggccgg cgccgggggt ctcctggacc gccggttcac cagccccggc 1261 agaggcccgg acgctgtcca gggtgctgaa gggcggctcc gtgcgcaagc tccggcgtgc 1321 caagcagttg gtgctggagc tgggcgagga ggcgatcttg gagggttgcg tcgggccccc 1381 cggggaggcg gctgtggggc tgctccagtt caatctcagc gagctgttca gttggtggat 1441 tcgccaaggc gaagggcgac tgaggatccg cctgatgccc gagaagaagg cgtcggaagt 1501 gggcagagag ggaaggctgt ccgcggcaat tcgcgcctcc cagccccgcc ttctcttcca 1561 gatcttcggg actggtcata gctccttgga atcaccaaca aacatgcctt ctccttctcc 1621 tgattatttt acatggaatc tcacctggat aatgaaagac tccttccctt tcctgtctca 1681 tcgcagccga tatggtctgg agtgcagctt tgacttcccc tgtgagctgg agtattcccc 1741 tccactgcat gacctcagga accagagctg gtcctggcgc cgcatcccct ccgaggaggc 1801 ctcccagatg gacttgctgg atgggcctgg ggcagagcgt tctaaggaga tgcccagagg 1861 ctcctttctc cttctcaaca cctcagctga ctccaagcac accatcctga gtccgtggat 1921 gaggagcagc agtgagcact gcacactggc cgtctcggtg cacaggcacc tgcagccctc 1981 tggaaggtac attgcccagc tgctgcccca caacgaggct gcaagagaga tcctcctgat 2041 gcccactcca gggaagcatg gttggacagt gctccaggga agaatcgggc gtccagacaa 2101 cccatttcga gtggccctgg aatacatctc cagtggaaac cgcagcttgt ctgcagtgga 2161 cttctttgcc ctgaagaact gcagtgaagg aacatcccca ggctccaaga tggccctgca 2221 gagctccttc acttgttgga atgggacagt cctccagctt gggcaggcct gtgacttcca 2281 ccaggactgt gcccagggag aagatgagag ccagatgtgc cggaaactgc ctgtgggttt 2341 ttactgcaac tttgaagatg gcttctgtgg ctggacccaa ggcacactgt caccccacac 2401 tcctcaatgg caggtcagga ccctaaagga tgcccggttc caggaccacc aagaccatgc 2461 tctattgctc agtaccactg atgtccccgc ttctgaaagt gctacagtga ccagtgctac 2521 gtttcctgca ccgatcaaga gctctccatg tgagctccga atgtcctggc tcattcgtgg 2581 agtcttgagg ggaaacgtgt ccttggtgct agtggagaac aaaaccggga aggagcaagg 2641 caggatggtc tggcatgtcg ccgcctatga aggcttgagc ctgtggcagt ggatggtgtt 2701 gcctctcctc gatgtgtctg acaggttctg gctgcagatg gtcgcatggt ggggacaagg 2761 atccagagcc atcgtggctt ttgacaatat ctccatcagc ctggactgct acctcaccat 2821 tagcggagag gacaagatcc tgcagaatac agcacccaaa tcaagaaacc tgtttgagag 2881 aaacccaaac aaggagctga aacccgggga aaattcacca agacagaccc ccatctttga 2941 ccctacagtt cattggctgt tcaccacatg tggggccagc gggccccatg gccccaccca 3001 ggcacagtgc aacaacgcct accagaactc caacctgagc gtggaggtgg ggagcgaggg 3061 ccccctgaaa ggcatccaga tctggaaggt gccagccacc gacacctaca gcatctcggg 3121 ctacggagct gctggcggga aaggcgggaa gaacaccatg atgcggtccc acggcgtgtc 3181 tgtgctgggc atcttcaacc tggagaagga tgacatgctg tacatcctgg ttgggcagca 3241 gggagaggac gcctgcccca gtacaaacca gttaatccag aaagtctgca ttggagagaa 3301 caatgtgata gaagaagaaa tccgtgtgaa cagaagcgtg catgagtggg caggaggcgg 3361 aggaggaggg ggtggagcca cctacgtatt taagatgaag gatggagtgc cggtgcccct 3421 gatcattgca gccggaggtg gtggcagggc ctacggggcc aagacagaca cgttccaccc 3481 agagagactg gagaataact cctcggttct agggctaaac ggcaattccg gagccgcagg 3541 tggtggaggt ggctggaatg ataacacttc cttgctctgg gccggaaaat ctttgcagga 3601 gggtgccacc ggaggacatt cctgccccca ggccatgaag aagtgggggt gggagacaag 3661 agggggtttc ggagggggtg gaggggggtg ctcctcaggt ggaggaggcg gaggatatat 3721 aggcggcaat gcagcctcaa acaatgaccc cgaaatggat ggggaagatg gggtttcctt 3781 catcagtcca ctgggcatcc tgtacacccc agctttaaaa gtgatggaag gccacgggga 3841 agtgaatatt aagcattatc taaactgcag tcactgtgag gtagacgaat gtcacatgga 3901 ccctgaaagc cacaaggtca tctgcttctg tgaccacggg acggtgctgg ctgaggatgg 3961 cgtctcctgc attgtgtcac ccaccccgga gccacacctg ccactctcgc tgatcctctc 4021 tgtggtgacc tctgccctcg tggccgccct ggtcctggct ttctccggca tcatgattgt 4081 gtaccgccgg aagcaccagg agctgcaagc catgcagatg gagctgcaga gccctgagta 4141 caagctgagc aagctccgca cctcgaccat catgaccgac tacaacccca actactgctt 4201 tgctggcaag acctcctcca tcagtgacct gaaggaggtg ccgcggaaaa acatcaccct 4261 cattcggggt ctgggccatg gcgcctttgg ggaggtgtat gaaggccagg tgtccggaat 4321 gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg ctgcctgaag tgtgctctga 4381 acaggacgaa ctggatttcc tcatggaagc cctgatcatc agcaaattca accaccagaa 4441 cattgttcgc tgcattgggg tgagcctgca atccctgccc cggttcatcc tgctggagct 4501 catggcgggg ggagacctca agtccttcct ccgagagacc cgccctcgcc cgagccagcc 4561 ctcctccctg gccatgctgg accttctgca cgtggctcgg gacattgcct gtggctgtca 4621 gtatttggag gaaaaccact tcatccaccg agacattgct gccagaaact gcctcttgac 4681 ctgtccaggc cctggaagag tggccaagat tggagacttc gggatggccc aagacatcta 4741 cagggcgagc tactatagaa agggaggctg tgccatgctg ccagttaagt ggatgccccc 4801 agaggccttc atggaaggaa tattcacttc taaaacagac acatggtcct ttggagtgct 4861 gctatgggaa atcttttctc ttggatatat gccatacccc agcaaaagca accaggaagt 4921 tctggagttt gtcaccagtg gaggccggat ggacccaccc aagaactgcc ctgggcctgt 4981 ataccggata atgactcagt gctggcaaca tcagcctgaa gacaggccca actttgccat 5041 cattttggag aggattgaat actgcaccca ggacccggat gtaatcaaca ccgctttgcc 5101 gatagaatat ggtccacttg tggaagagga agagaaagtg cctgtgaggc ccaaggaccc 5161 tgagggggtt cctcctctcc tggtctctca acaggcaaaa cgggaggagg agcgcagccc 5221 agctgcccca ccacctctgc ctaccacctc ctctggcaag gctgcaaaga aacccacagc 5281 tgcagagatc tctgttcgag tccctagagg gccggccgtg gaagggggac acgtgaatat 5341 ggcattctct cagtccaacc ctccttcgga gttgcacaag gtccacggat ccagaaacaa 5401 gcccaccagc ttgtggaacc caacgtacgg ctcctggttt acagagaaac ccaccaaaaa 5461 gaataatcct atagcaaaga aggagccaca cgacaggggt aacctggggc tggagggaag 5521 ctgtactgtc ccacctaacg ttgcaactgg gagacttccg ggggcctcac tgctcctaga 5581 gccctcttcg ctgactgcca atatgaagga ggtacctctg ttcaggctac gtcacttccc 5641 ttgtgggaat gtcaattacg gctaccagca acagggcttg cccttagaag ccgctactgc 5701 ccctggagct ggtcattacg aggataccat tctgaaaagc aagaatagca tgaaccagcc 5761 tgggccctga gctcggtcgc acactcactt ctcttccttg ggatccctaa gaccgtggag 5821 gagagagagg caatggctcc ttcacaaacc agagaccaaa tgtcacgttt tgttttgtgc 5881 caacctattt tgaagtacca ccaaaaaagc tgtattttga aaatgcttta gaaaggtttt 5941 gagcatgggt tcatcctatt ctttcgaaag aagaaaatat cataaaaatg agtgataaat 6001 acaaggccca gatgtggttg cataaggttt ttatgcatgt ttgttgtata cttccttatg 6061 cttctttcaa attgtgtgtg ctctgcttca atgtagtcag aattagctgc ttctatgttt 6121 catagttggg gtcatagatg tttccttgcc ttgttgatgt ggacatgagc catttgaggg 6181 gagagggaac ggaaataaag gagttatttg taatgactaa aa //