LOCUS       EU788008                6222 bp    mRNA    linear   HUM 17-OCT-2008
DEFINITION  Homo sapiens mutant F1174V anaplastic lymphoma kinase (ALK) mRNA,
            complete cds.
ACCESSION   EU788008
VERSION     EU788008.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6222)
  AUTHORS   Chen,Y., Takita,J., Choi,Y.L., Kato,M., Ohira,M., Sanada,M.,
            Wang,L., Soda,M., Kikuchi,A., Igarashi,T., Nakagawara,A.,
            Hayashi,Y., Mano,H. and Ogawa,S.
  TITLE     Oncogenic mutations of ALK kinase in neuroblastoma
  JOURNAL   Nature 455 (7215), 971-974 (2008)
   PUBMED   18923524
REFERENCE   2  (bases 1 to 6222)
  AUTHORS   Chen,Y., Takita,J., Choi,Y.L., Kato,M., Ohira,M., Sanada,M.,
            Wang,L., Soda,M., Kikuchi,A., Igarashi,T., Nakagawara,A.,
            Hayashi,Y., Mano,H. and Ogawa,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-JUN-2008) Pediatrics, Graduate School of Medicine,
            University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan
FEATURES             Location/Qualifiers
     source          1..6222
                     /db_xref="H-InvDB:HIT000558068"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="mutant F1174V"
                     /db_xref="taxon:9606"
                     /tissue_type="neuroblastoma"
     gene            1..6222
                     /gene="ALK"
     CDS             908..5770
                     /gene="ALK"
                     /codon_start=1
                     /product="anaplastic lymphoma kinase"
                     /protein_id="ACI47596.1"
                     /translation="MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPL
                     SYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLL
                     GPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGE
                     AAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQ
                     IFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEY
                     SPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTIL
                     SPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGR
                     IGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQ
                     LGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSPHTPQWQVRTLKD
                     ARFQDHQDHALLLSTTDVPASESATVTSATFPAPIKSSPCELRMSWLIRGVLRGNVSL
                     VLVENKTGKEQGRMVWHVAAYEGLSLWQWMVLPLLDVSDRFWLQMVAWWGQGSRAIVA
                     FDNISISLDCYLTISGEDKILQNTAPKSRNLFERNPNKELKPGENSPRQTPIFDPTVH
                     WLFTTCGASGPHGPTQAQCNNAYQNSNLSVEVGSEGPLKGIQIWKVPATDTYSISGYG
                     AAGGKGGKNTMMRSHGVSVLGIFNLEKDDMLYILVGQQGEDACPSTNQLIQKVCIGEN
                     NVIEEEIRVNRSVHEWAGGGGGGGGATYVFKMKDGVPVPLIIAAGGGGRAYGAKTDTF
                     HPERLENNSSVLGLNGNSGAAGGGGGWNDNTSLLWAGKSLQEGATGGHSCPQAMKKWG
                     WETRGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGEDGVSFISPLGILYTPALKV
                     MEGHGEVNIKHYLNCSHCEVDECHMDPESHKVICFCDHGTVLAEDGVSCIVSPTPEPH
                     LPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTSTI
                     MTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQ
                     VAVKTLPEVCSEQDELDFLMEALIISKVNHQNIVRCIGVSLQSLPRFILLELMAGGDL
                     KSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGP
                     GRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLW
                     EIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAI
                     ILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEER
                     SPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHG
                     SRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLEGSCTVPPNVATGRLPG
                     ASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGYQQQGLPLEAATAPGAGHYEDTILK
                     SKNSMNQPGP"
BASE COUNT         1378 a         1746 c         1858 g         1240 t
ORIGIN      
        1 gggggcggca gcggtggtag cagctggtac ctcccgccgc ctctgttcgg agggtcgcgg
       61 ggcaccgagg tgctttccgg ccgccctctg gtcggccacc caaagccgcg ggcgctgatg
      121 atgggtgagg agggggcggc aagatttcgg gcgcccctgc cctgaacgcc ctcagctgct
      181 gccgccgggg ccgctccagt gcctgcgaac tctgaggagc cgaggcgccg gtgagagcaa
      241 ggacgctgca aacttgcgca gcgcgggggc tgggattcac gcccagaagt tcagcaggca
      301 gacagtccga agccttcccg cagcggagag atagcttgag ggtgcgcaag acggcagcct
      361 ccgccctcgg ttcccgccca gaccgggcag aagagcttgg aggagccaaa aggaacgcaa
      421 aaggcggcca ggacagcgtg cagcagctgg gagccgccgt tctcagcctt aaaagttgca
      481 gagattggag gctgccccga gaggggacag accccagctc cgactgcggg gggcaggaga
      541 ggacggtacc caactgccac ctcccttcaa ccatagtagt tcctctgtac cgagcgcagc
      601 gagctacaga cgggggcgcg gcactcggcg cggagagcgg gaggctcaag gtcccagcca
      661 gtgagcccag tgtgcttgag tgtctctgga ctcgcccctg agcttccagg tctgtttcat
      721 ttagactcct gctcgcctcc gtgcagttgg gggaaagcaa gagacttgcg cgcacgcaca
      781 gtcctctgga gatcaggtgg aaggagccgc tgggtaccaa ggactgttca gagcctcttc
      841 ccatctcggg gagagcgaag ggtgaggctg ggcccggaga gcagtgtaaa cggcctcctc
      901 cggcgggatg ggagccatcg ggctcctgtg gctcctgccg ctgctgcttt ccacggcagc
      961 tgtgggctcc gggatgggga ccggccagcg cgcgggctcc ccagctgcgg ggccgccgct
     1021 gcagccccgg gagccactca gctactcgcg cctgcagagg aagagtctgg cagttgactt
     1081 cgtggtgccc tcgctcttcc gtgtctacgc ccgggaccta ctgctgccac catcctcctc
     1141 ggagctgaag gctggcaggc ccgaggcccg cggctcgcta gctctggact gcgccccgct
     1201 gctcaggttg ctggggccgg cgccgggggt ctcctggacc gccggttcac cagccccggc
     1261 agaggcccgg acgctgtcca gggtgctgaa gggcggctcc gtgcgcaagc tccggcgtgc
     1321 caagcagttg gtgctggagc tgggcgagga ggcgatcttg gagggttgcg tcgggccccc
     1381 cggggaggcg gctgtggggc tgctccagtt caatctcagc gagctgttca gttggtggat
     1441 tcgccaaggc gaagggcgac tgaggatccg cctgatgccc gagaagaagg cgtcggaagt
     1501 gggcagagag ggaaggctgt ccgcggcaat tcgcgcctcc cagccccgcc ttctcttcca
     1561 gatcttcggg actggtcata gctccttgga atcaccaaca aacatgcctt ctccttctcc
     1621 tgattatttt acatggaatc tcacctggat aatgaaagac tccttccctt tcctgtctca
     1681 tcgcagccga tatggtctgg agtgcagctt tgacttcccc tgtgagctgg agtattcccc
     1741 tccactgcat gacctcagga accagagctg gtcctggcgc cgcatcccct ccgaggaggc
     1801 ctcccagatg gacttgctgg atgggcctgg ggcagagcgt tctaaggaga tgcccagagg
     1861 ctcctttctc cttctcaaca cctcagctga ctccaagcac accatcctga gtccgtggat
     1921 gaggagcagc agtgagcact gcacactggc cgtctcggtg cacaggcacc tgcagccctc
     1981 tggaaggtac attgcccagc tgctgcccca caacgaggct gcaagagaga tcctcctgat
     2041 gcccactcca gggaagcatg gttggacagt gctccaggga agaatcgggc gtccagacaa
     2101 cccatttcga gtggccctgg aatacatctc cagtggaaac cgcagcttgt ctgcagtgga
     2161 cttctttgcc ctgaagaact gcagtgaagg aacatcccca ggctccaaga tggccctgca
     2221 gagctccttc acttgttgga atgggacagt cctccagctt gggcaggcct gtgacttcca
     2281 ccaggactgt gcccagggag aagatgagag ccagatgtgc cggaaactgc ctgtgggttt
     2341 ttactgcaac tttgaagatg gcttctgtgg ctggacccaa ggcacactgt caccccacac
     2401 tcctcaatgg caggtcagga ccctaaagga tgcccggttc caggaccacc aagaccatgc
     2461 tctattgctc agtaccactg atgtccccgc ttctgaaagt gctacagtga ccagtgctac
     2521 gtttcctgca ccgatcaaga gctctccatg tgagctccga atgtcctggc tcattcgtgg
     2581 agtcttgagg ggaaacgtgt ccttggtgct agtggagaac aaaaccggga aggagcaagg
     2641 caggatggtc tggcatgtcg ccgcctatga aggcttgagc ctgtggcagt ggatggtgtt
     2701 gcctctcctc gatgtgtctg acaggttctg gctgcagatg gtcgcatggt ggggacaagg
     2761 atccagagcc atcgtggctt ttgacaatat ctccatcagc ctggactgct acctcaccat
     2821 tagcggagag gacaagatcc tgcagaatac agcacccaaa tcaagaaacc tgtttgagag
     2881 aaacccaaac aaggagctga aacccgggga aaattcacca agacagaccc ccatctttga
     2941 ccctacagtt cattggctgt tcaccacatg tggggccagc gggccccatg gccccaccca
     3001 ggcacagtgc aacaacgcct accagaactc caacctgagc gtggaggtgg ggagcgaggg
     3061 ccccctgaaa ggcatccaga tctggaaggt gccagccacc gacacctaca gcatctcggg
     3121 ctacggagct gctggcggga aaggcgggaa gaacaccatg atgcggtccc acggcgtgtc
     3181 tgtgctgggc atcttcaacc tggagaagga tgacatgctg tacatcctgg ttgggcagca
     3241 gggagaggac gcctgcccca gtacaaacca gttaatccag aaagtctgca ttggagagaa
     3301 caatgtgata gaagaagaaa tccgtgtgaa cagaagcgtg catgagtggg caggaggcgg
     3361 aggaggaggg ggtggagcca cctacgtatt taagatgaag gatggagtgc cggtgcccct
     3421 gatcattgca gccggaggtg gtggcagggc ctacggggcc aagacagaca cgttccaccc
     3481 agagagactg gagaataact cctcggttct agggctaaac ggcaattccg gagccgcagg
     3541 tggtggaggt ggctggaatg ataacacttc cttgctctgg gccggaaaat ctttgcagga
     3601 gggtgccacc ggaggacatt cctgccccca ggccatgaag aagtgggggt gggagacaag
     3661 agggggtttc ggagggggtg gaggggggtg ctcctcaggt ggaggaggcg gaggatatat
     3721 aggcggcaat gcagcctcaa acaatgaccc cgaaatggat ggggaagatg gggtttcctt
     3781 catcagtcca ctgggcatcc tgtacacccc agctttaaaa gtgatggaag gccacgggga
     3841 agtgaatatt aagcattatc taaactgcag tcactgtgag gtagacgaat gtcacatgga
     3901 ccctgaaagc cacaaggtca tctgcttctg tgaccacggg acggtgctgg ctgaggatgg
     3961 cgtctcctgc attgtgtcac ccaccccgga gccacacctg ccactctcgc tgatcctctc
     4021 tgtggtgacc tctgccctcg tggccgccct ggtcctggct ttctccggca tcatgattgt
     4081 gtaccgccgg aagcaccagg agctgcaagc catgcagatg gagctgcaga gccctgagta
     4141 caagctgagc aagctccgca cctcgaccat catgaccgac tacaacccca actactgctt
     4201 tgctggcaag acctcctcca tcagtgacct gaaggaggtg ccgcggaaaa acatcaccct
     4261 cattcggggt ctgggccatg gcgcctttgg ggaggtgtat gaaggccagg tgtccggaat
     4321 gcccaacgac ccaagccccc tgcaagtggc tgtgaagacg ctgcctgaag tgtgctctga
     4381 acaggacgaa ctggatttcc tcatggaagc cctgatcatc agcaaagtca accaccagaa
     4441 cattgttcgc tgcattgggg tgagcctgca atccctgccc cggttcatcc tgctggagct
     4501 catggcgggg ggagacctca agtccttcct ccgagagacc cgccctcgcc cgagccagcc
     4561 ctcctccctg gccatgctgg accttctgca cgtggctcgg gacattgcct gtggctgtca
     4621 gtatttggag gaaaaccact tcatccaccg agacattgct gccagaaact gcctcttgac
     4681 ctgtccaggc cctggaagag tggccaagat tggagacttc gggatggccc gagacatcta
     4741 cagggcgagc tactatagaa agggaggctg tgccatgctg ccagttaagt ggatgccccc
     4801 agaggccttc atggaaggaa tattcacttc taaaacagac acatggtcct ttggagtgct
     4861 gctatgggaa atcttttctc ttggatatat gccatacccc agcaaaagca accaggaagt
     4921 tctggagttt gtcaccagtg gaggccggat ggacccaccc aagaactgcc ctgggcctgt
     4981 ataccggata atgactcagt gctggcaaca tcagcctgaa gacaggccca actttgccat
     5041 cattttggag aggattgaat actgcaccca ggacccggat gtaatcaaca ccgctttgcc
     5101 gatagaatat ggtccacttg tggaagagga agagaaagtg cctgtgaggc ccaaggaccc
     5161 tgagggggtt cctcctctcc tggtctctca acaggcaaaa cgggaggagg agcgcagccc
     5221 agctgcccca ccacctctgc ctaccacctc ctctggcaag gctgcaaaga aacccacagc
     5281 tgcagagatc tctgttcgag tccctagagg gccggccgtg gaagggggac acgtgaatat
     5341 ggcattctct cagtccaacc ctccttcgga gttgcacaag gtccacggat ccagaaacaa
     5401 gcccaccagc ttgtggaacc caacgtacgg ctcctggttt acagagaaac ccaccaaaaa
     5461 gaataatcct atagcaaaga aggagccaca cgacaggggt aacctggggc tggagggaag
     5521 ctgtactgtc ccacctaacg ttgcaactgg gagacttccg ggggcctcac tgctcctaga
     5581 gccctcttcg ctgactgcca atatgaagga ggtacctctg ttcaggctac gtcacttccc
     5641 ttgtgggaat gtcaattacg gctaccagca acagggcttg cccttagaag ccgctactgc
     5701 ccctggagct ggtcattacg aggataccat tctgaaaagc aagaatagca tgaaccagcc
     5761 tgggccctga gctcggtcgc acactcactt ctcttccttg ggatccctaa gaccgtggag
     5821 gagagagagg caatggctcc ttcacaaacc agagaccaaa tgtcacgttt tgttttgtgc
     5881 caacctattt tgaagtacca ccaaaaaagc tgtattttga aaatgcttta gaaaggtttt
     5941 gagcatgggt tcatcctatt ctttcgaaag aagaaaatat cataaaaatg agtgataaat
     6001 acaaggccca gatgtggttg cataaggttt ttatgcatgt ttgttgtata cttccttatg
     6061 cttctttcaa attgtgtgtg ctctgcttca atgtagtcag aattagctgc ttctatgttt
     6121 catagttggg gtcatagatg tttccttgcc ttgttgatgt ggacatgagc catttgaggg
     6181 gagagggaac ggaaataaag gagttatttg taatgactaa aa
//