LOCUS EU709494 4815 bp mRNA linear HUM 08-JUN-2008
DEFINITION Homo sapiens truncated E-cadherin (CDH1) mRNA, complete cds.
ACCESSION EU709494
VERSION EU709494.1
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 4815)
AUTHORS Ghaffari,S.R., Rafati,M., Sabokbar,T. and Dastan,J.
TITLE A novel mutation in the E-cadherin gene in the first family with
hereditary diffuse gastric cancer reported in Iran
JOURNAL Unpublished
REFERENCE 2 (bases 1 to 4815)
AUTHORS Ghaffari,S.R., Rafati,M., Sabokbar,T. and Dastan,J.
TITLE Direct Submission
JOURNAL Submitted (08-MAY-2008) Reproductive Genetics, Reproductive Health
Research Center, Keshavarz Blvd, Tehran, Iran
FEATURES Location/Qualifiers
source 1..4815
/db_xref="H-InvDB:HIT000558021"
/organism="Homo sapiens"
/mol_type="mRNA"
/isolation_source="patient with diffuse gastric cancer"
/db_xref="taxon:9606"
/chromosome="16"
/map="16q22.1"
/country="Iran"
gene 1..4815
/gene="CDH1"
CDS 125..2401
/gene="CDH1"
/note="cadherin 1, type 1, E-cadherin (epithelial)"
/codon_start=1
/product="truncated E-cadherin"
/protein_id="ACD87624.1"
/translation="MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRR
HLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYA
WDSTYRKFSTKVTLNTVGHHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPP
ISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTE
PLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGAL
PGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLD
RESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVV
ITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQY
ILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSY
TAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALII
ATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTS
PFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLE
VSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEP
LLPPEDDTRDNVYYYDEE"
variation 2399
/gene="CDH1"
/note="G759X"
/replace="g"
BASE COUNT 1249 a 1185 c 1137 g 1244 t
ORIGIN
1 agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc
61 gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc
121 agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc
181 ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt
241 cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga
301 ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac
361 agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt
421 ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt
481 ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt
541 gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc
601 tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa
661 atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac
721 accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc
781 tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg
841 gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa
901 gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac
961 ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc
1021 catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat
1081 taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc
1141 tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc
1201 aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac
1261 gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac
1321 tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga
1381 tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc
1441 aaagggcttg gattttgagg ccaagcagca gtacattcta cacgtagcag tgacgaatgt
1501 ggtacctttt gaggtctctc tcaccacctc cacagccacc gtcaccgtgg atgtgctgga
1561 tgtgaatgaa gcccccatct ttgtgcctcc tgaaaagaga gtggaagtgt ccgaggactt
1621 tggcgtgggc caggaaatca catcctacac tgcccaggag ccagacacat ttatggaaca
1681 gaaaataaca tatcggattt ggagagacac tgccaactgg ctggagatta atccggacac
1741 tggtgccatt tccactcggg ctgagctgga cagggaggat tttgagcacg tgaagaacag
1801 cacgtacaca gccctaatca tagctacaga caatggttct ccagttgcta ctggaacagg
1861 gacacttctg ctgatcctgt ctgatgtgaa tgacaacgcc cccataccag aacctcgaac
1921 tatattcttc tgtgagagga atccaaagcc tcaggtcata aacatcattg atgcagacct
1981 tcctcccaat acatctccct tcacagcaga actaacacac ggggcgagtg ccaactggac
2041 cattcagtac aacgacccaa cccaagaatc tatcattttg aagccaaaga tggccttaga
2101 ggtgggtgac tacaaaatca atctcaagct catggataac cagaataaag accaagtgac
2161 caccttagag gtcagcgtgt gtgactgtga aggggccgct ggcgtctgta ggaaggcaca
2221 gcctgtcgaa gcaggattgc aaattcctgc cattctgggg attcttggag gaattcttgc
2281 tttgctaatt ctgattctgc tgctcttgct gtttcttcgg aggagagcgg tggtcaaaga
2341 gcccttactg cccccagagg atgacacccg ggacaacgtt tattactatg atgaagaatg
2401 aggcggagaa gaggaccagg actttgactt gagccagctg cacaggggcc tggacgctcg
2461 gcctgaagtg actcgtaacg acgttgcacc aaccctcatg agtgtccccc ggtatcttcc
2521 ccgccctgcc aatcccgatg aaattggaaa ttttattgat gaaaatctga aagcggctga
2581 tactgacccc acagccccgc cttatgattc tctgctcgtg tttgactatg aaggaagcgg
2641 ttccgaagct gctagtctga gctccctgaa ctcctcagag tcagacaaag accaggacta
2701 tgactacttg aacgaatggg gcaatcgctt caagaagctg gctgacatgt acggaggcgg
2761 cgaggacgac taggggactc gagagaggcg ggccccagac ccatgtgctg ggaaatgcag
2821 aaatcacgtt gctggtggtt tttcagctcc cttcccttga gatgagtttc tggggaaaaa
2881 aaagagactg gttagtgatg cagttagtat agctttatac tctctccact ttatagctct
2941 aataagtttg tgttagaaaa gtttcgactt atttcttaaa gctttttttt ttttcccatc
3001 actctttaca tggtggtgat gtccaaaaga tacccaaatt ttaatattcc agaagaacaa
3061 ctttagcatc agaaggttca cccagcacct tgcagatttt cttaaggaat tttgtctcac
3121 ttttaaaaag aaggggagaa gtcagctact ctagttctgt tgttttgtgt atataatttt
3181 ttaaaaaaaa tttgtgtgct tctgctcatt actacactgg tgtgtccctc tgcctttttt
3241 ttttttttaa gacagggtct cattctatcg gccaggctgg agtgcagtgg tgcaatcaca
3301 gctcactgca gccttgtcct cccaggctca agctatcctt gcacctcagc ctcccaagta
3361 gctgggacca caggcatgca ccactacgca tgactaattt tttaaatatt tgagacgggg
3421 tctccctgtg ttacccaggc tggtctcaaa ctcctgggct caagtgatcc tcccatcttg
3481 gcctcccaga gtattgggat tacagacatg agccactgca cctgcccagc tccccaactc
3541 cctgccattt tttaagagac agtttcgctc catcgcccag gcctgggatg cagtgatgtg
3601 atcatagctc actgtaacct caaactctgg ggctcaagca gttctcccac cagcctcctt
3661 tttatttttt tgtacagatg gggtcttgct atgttgccca agctggtctt aaactcctgg
3721 cctcaagcaa tccttctgcc ttggcccccc aaagtgctgg gattgtgggc atgagctgct
3781 gtgcccagcc tccatgtttt aatatcaact ctcactcctg aattcagttg ctttgcccaa
3841 gataggagtt ctctgatgca gaaattattg ggctctttta gggtaagaag tttgtgtctt
3901 tgtctggcca catcttgact aggtattgtc tactctgaag acctttaatg gcttccctct
3961 ttcatctcct gagtatgtaa cttgcaatgg gcagctatcc agtgacttgt tctgagtaag
4021 tgtgttcatt aatgtttatt tagctctgaa gcaagagtga tatactccag gacttagaat
4081 agtgcctaaa gtgctgcagc caaagacaga gcggaactat gaaaagtggg cttggagatg
4141 gcaggagagc ttgtcattga gcctggcaat ttagcaaact gatgctgagg atgattgagg
4201 tgggtctacc tcatctctga aaattctgga aggaatggag gagtctcaac atgtgtttct
4261 gacacaagat ccgtggtttg tactcaaagc ccagaatccc caagtgcctg cttttgatga
4321 tgtctacaga aaatgctggc tgagctgaac acatttgccc aattccaggt gtgcacagaa
4381 aaccgagaat attcaaaatt ccaaattttt ttcttaggag caagaagaaa atgtggccct
4441 aaagggggtt agttgagggg tagggggtag tgaggatctt gatttggatc tctttttatt
4501 taaatgtgaa tttcaacttt tgacaatcaa agaaaagact tttgttgaaa tagctttact
4561 gtttctcaag tgttttggag aaaaaaatca accctgcaat cactttttgg aattgtcttg
4621 atttttcggc agttcaagct atatcgaata tagttctgtg tagagaatgt cactgtagtt
4681 ttgagtgtat acatgtgtgg gtgctgataa ttgtgtattt tctttggggg tggaaaagga
4741 aaacaattca agctgagaaa agtattctca aagatgcatt tttataaatt ttattaaaca
4801 attttgttaa accat
//