LOCUS       EU434649                1269 bp    mRNA    linear   HUM 25-FEB-2008
DEFINITION  Homo sapiens gastric cancer hepatocellular carcinoma suppressor 1
            variant (HCCS1) mRNA, complete cds, alternatively spliced.
ACCESSION   EU434649
VERSION     EU434649.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1269)
  AUTHORS   Kang,X.D., Sun,J., Ni,Z.H. and Xie,S.
  TITLE     A deletion polymorphism of the putative tumor suppressor gene HCCS1
            in Chinese gastric cancer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1269)
  AUTHORS   Kang,X.D., Sun,J., Ni,Z.H. and Xie,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JAN-2008) Central Laboratory, Putuo Hospital
            Affiliated Shanghai University of Traditional Chinese Medicine,
            No.164 Lanxi Road, Shanghai 200062, China
FEATURES             Location/Qualifiers
     source          1..1269
                     /db_xref="H-InvDB:HIT000484976"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13"
                     /tissue_type="gastric cancer tissue"
                     /PCR_primers="fwd_seq: atgatggaggaggaggaactg, rev_seq:
                     ctacgtccatctcacctgttctg"
                     /PCR_primers="fwd_seq: gccaagattatgcgtaccagag, rev_seq:
                     catctctggtgttggctcatc"
     gene            1..1269
                     /gene="HCCS1"
     CDS             1..1269
                     /gene="HCCS1"
                     /note="lacks exons 5 through 11; includes exon 19; similar
                     to Homo sapiens vacuolar protein sorting 53 (VPS53);
                     alternatively spliced"
                     /codon_start=1
                     /product="gastric cancer hepatocellular carcinoma
                     suppressor 1 variant"
                     /protein_id="ACA21424.1"
                     /translation="MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNA
                     VEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQKKRESPP
                     PSTNPFLEDEPTPEMEELATEKGDLDQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQD
                     KNLGELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMI
                     ALTTIFQKYLREYAWKILSGNLPKTTTSSGGLTISSLLKEKEGSEVAKFTLEELCLIC
                     NILSTAEYCLATTQQLEEKLKEKVDVSLIERINLTGEMDTFSTVISSSIQLLVQDLDA
                     ACDPALTAMSKMQWQNVEHVGDQSPYVTSVILHIKQNVPIIRDNLASTRKYFTQFCVK
                     FANSFIPKFITHLFKCKPISMVGAEQVRWT"
     variation       293
                     /gene="HCCS1"
                     /replace="t"
     variation       565
                     /gene="HCCS1"
                     /replace="a"
     variation       693
                     /gene="HCCS1"
                     /replace="t"
     variation       727
                     /gene="HCCS1"
                     /replace="c"
     variation       743
                     /gene="HCCS1"
                     /replace="a"
     variation       1135^1136
                     /gene="HCCS1"
                     /note="microdeletion"
     variation       1167
                     /gene="HCCS1"
                     /replace="a"
     variation       1185
                     /gene="HCCS1"
                     /replace="g"
     variation       1187..1188
                     /gene="HCCS1"
                     /replace="aa"
BASE COUNT          356 a          334 c          317 g          262 t
ORIGIN      
        1 atgatggagg aggaggaact ggagttcgtg gaggagctgg aagccgtgct gcagctcacg
       61 cccgaggtgc agctggccat cgagcaggtg tttccaagcc aggaccctct agatcgagca
      121 gatttcaatg ctgttgagta tatcaatacc ctgttcccaa ccgagcaatc tctggcgaac
      181 atagacgaag tcgtgaacaa aattaggctg aaaataagga gactggatga caatattcga
      241 actgttgtaa gaggtcagac gaacgtgggg caggatggac ggcaaaaaaa gcgtgagtct
      301 ccacccccat ctaccaatcc cttcctggaa gatgagccaa caccagagat ggaggaactg
      361 gcaacggaga aaggagattt agatcaacca aagaagccta aagccccaga caatccattt
      421 catggcattg tttccaagtg ttttgagcct catctctacg tgtatatcga atcccaagac
      481 aagaacctcg gagagctgat agatcggttt gtggctgatt tcaaagccca ggggccacct
      541 aagcccaaca ctgatgaagg gggtgccgtg ctccccagct gcgccgacct ctttgtctac
      601 tacaagaagt gcatggtgca atgctctcag ctcagtactg gggagcccat gatcgccctg
      661 accaccattt tccagaagta cctccgagaa tacgcctgga aaatcctctc tggcaacctg
      721 cccaaaacca caaccagcag tggaggactg actatcagca gcctcctcaa ggaaaaggag
      781 ggctcagaag tagccaagtt cactctggag gagctctgcc tcatctgtaa catcctgagc
      841 acggcagagt actgtctggc caccacccag cagctagaag aaaaactcaa agaaaaagtg
      901 gatgtaagtc tgattgaacg aatcaatctg actggagaga tggacacgtt cagcaccgtc
      961 atctccagca gtattcagct gctggttcag gatctggatg ctgcctgtga tcctgccctg
     1021 actgccatga gcaagatgca gtggcagaac gtggagcacg ttggtgacca gagcccctac
     1081 gtcacctctg tcattctgca catcaagcag aacgtcccca tcatccgtga caacctggct
     1141 tccacacgca agtacttcac tcagttctgc gttaaatttg caaactcctt cattcccaaa
     1201 ttcatcaccc acctcttcaa gtgcaagcca attagcatgg tgggagcaga acaggtgaga
     1261 tggacgtag
//