LOCUS       EU434648                1903 bp    mRNA    linear   HUM 25-FEB-2008
DEFINITION  Homo sapiens gastric cancer hepatocellular carcinoma suppressor 1
            variant (HCCS1) mRNA, complete cds, alternatively spliced.
ACCESSION   EU434648
VERSION     EU434648.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Kang,X.D., Sun,J., Ni,Z.H. and Xie,S.
  TITLE     A deletion polymorphism of the putative tumor suppressor gene HCCS1
            in Chinese gastric cancer
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Kang,X.D., Sun,J., Ni,Z.H. and Xie,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-JAN-2008) Central Laboratory, Putuo Hospital
            Affiliated Shanghai University of Traditional Chinese Medicine,
            No.164 Lanxi Road, Shanghai 200062, China
FEATURES             Location/Qualifiers
     source          1..1903
                     /db_xref="H-InvDB:HIT000484975"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13"
                     /tissue_type="gastric cancer tissue"
                     /PCR_primers="fwd_seq: atgatggaggaggaggaactg, rev_seq:
                     ctacgtccatctcacctgttctg"
                     /PCR_primers="fwd_seq: gccaagattatgcgtaccagag, rev_seq:
                     catctctggtgttggctcatc"
     gene            1..1903
                     /gene="HCCS1"
     CDS             1..1644
                     /gene="HCCS1"
                     /note="lacks exon 19 and part of exon 16; similar to Homo
                     sapiens vacuolar protein sorting 53 (VPS53); alternatively
                     spliced"
                     /codon_start=1
                     /product="gastric cancer hepatocellular carcinoma
                     suppressor 1 variant"
                     /protein_id="ACA21423.1"
                     /translation="MMEEEELEFVEELEAVLQLTPEVQLAIEQVFPSQDPLDRADFNA
                     VEYINTLFPTEQSLANIDEVVNKIRLKIRRLDDNIRTVVRGQTNVGQDGRQALEEAQK
                     AIQQLFGKIKDIKDKAEKSEQMVKEITRDIKQLDHAKRHLTTSITTLNHLHMLAGGVD
                     SLEAMTRRRQYGEVANLLQGVMNVLEHFHKYMGIPQIRQLSERVKAAQTELGQQILAD
                     FEEAFPSQGTKVAWLDKIDRRYAWIKRQLVDYEEKYGRMFPREWCMAERIAVEFCHVT
                     RAELAKIMRTRAKEIEVKLLLFAIQRTTNFEGFLAKRFSGCTLTDGTLKKRESPPPST
                     NPFLEDEPTPEMEELATEKGDLDQPKKPKAPDNPFHGIVSKCFEPHLYVYIESQDKNL
                     GELIDRFVADFKAQGPPKPNTDEGGAVLPSCADLFVYYKKCMVQCSQLSTGEPMIALT
                     TIFQKYLREYAWKILSGNLPKTTTSSGGLTISSLLKEKEGSEVAKFTLEELCLICNIL
                     STAEYCLATTQQLEEKLKEKVDRHLQQYSAAGSGSGCCL"
     variation       980
                     /gene="HCCS1"
                     /replace="t"
     variation       1252
                     /gene="HCCS1"
                     /replace="a"
     variation       1380
                     /gene="HCCS1"
                     /replace="t"
     variation       1414
                     /gene="HCCS1"
                     /replace="c"
     variation       1430
                     /gene="HCCS1"
                     /replace="a"
     variation       1769^1770
                     /gene="HCCS1"
                     /note="microdeletion"
     variation       1801
                     /gene="HCCS1"
                     /replace="a"
     variation       1818
                     /gene="HCCS1"
                     /replace="c"
     variation       1820
                     /gene="HCCS1"
                     /replace="aa"
BASE COUNT          544 a          485 c          477 g          397 t
ORIGIN      
        1 atgatggagg aggaggaact ggagttcgtg gaggagctgg aagccgtgct gcagctcacg
       61 cccgaggtgc agctggccat cgagcaggtg tttccaagcc aggaccctct agatcgagca
      121 gatttcaatg ctgttgagta tatcaatacc ctgttcccaa ccgagcaatc tctggcgaac
      181 atagacgaag tcgtgaacaa aattaggctg aaaataagga gactggatga caatattcga
      241 actgttgtaa gaggtcagac gaacgtgggg caggatggac ggcaagcgct tgaagaggct
      301 cagaaagcta tccaacaact ctttggcaaa atcaaagata tcaaagacaa agctgaaaaa
      361 tcagagcaaa tggtgaaaga aatcacccgt gatattaagc aattagatca cgccaaacgc
      421 cacctgacca cctcaatcac cacactgaac cacctgcaca tgctggcagg aggtgtcgac
      481 tccctcgaag ccatgaccag gcgaagacaa tacggagaag ttgctaatct ccttcagggt
      541 gtgatgaatg tcctggagca cttccacaag tatatgggga ttccgcagat ccggcagctt
      601 tccgaaagag tgaaggctgc acagactgag ttaggacagc aaatcctggc agattttgaa
      661 gaagcgtttc cttcccaggg caccaaggtt gcctggctgg acaaaatcga cagacgctat
      721 gcctggataa aacgccagct tgtggactat gaggagaaat acggccgcat gtttccacgt
      781 gagtggtgca tggctgagag gattgcggtg gaattttgcc atgtgacaag ggcagaactt
      841 gccaagatta tgcgtaccag agcgaaggaa attgaagtga aattgcttct ttttgctatt
      901 caaagaacaa ctaactttga ggggtttctt gcaaaacgct tctccggctg caccctgacc
      961 gatgggaccc tgaaaaagcg tgagtctcca cccccatcta ccaatccctt cctggaagat
     1021 gagccaacac cagagatgga ggaactggca acggagaaag gagatttaga tcaaccaaag
     1081 aagcctaaag ccccagacaa tccatttcat ggcattgttt ccaagtgttt tgagcctcat
     1141 ctctacgtgt atatcgaatc ccaagacaag aacctcggag agctgataga tcggtttgtg
     1201 gctgatttca aagcccaggg gccacctaag cccaacactg atgaaggggg tgccgtgctc
     1261 cccagctgcg ccgacctctt tgtctactac aagaagtgca tggtgcaatg ctctcagctc
     1321 agtactgggg agcccatgat cgccctgacc accattttcc agaagtacct ccgagaatac
     1381 gcctggaaaa tcctctctgg caacctgccc aaaaccacaa ccagcagtgg aggactgact
     1441 atcagcagcc tcctcaagga aaaggagggc tcagaagtag ccaagttcac tctggaggag
     1501 ctctgcctca tctgtaacat cctgagcacg gcagagtact gtctggccac cacccagcag
     1561 ctagaagaaa aactcaaaga aaaagtggat cgtcatctcc agcagtattc agctgctggt
     1621 tcaggatctg gatgctgcct gtgatcctgc cctgactgcc atgagcaaga tgcagtggca
     1681 gaacgtggag cacgttggtg accagagccc ctacgtcacc tctgtcattc tgcacatcaa
     1741 gcagaacgtc cccatcatcc gtgacaacct ggcttccaca cgcaagtact tcactcagtt
     1801 ctgcgttaaa tttgcaaact ccttcattcc caaattcatc acccacctct tcaagtgcaa
     1861 gccaattagc atggtgggag cagaacaggt gagatggacg tag
//