LOCUS EU408704 1647 bp mRNA linear HUM 07-JUN-2008 DEFINITION Homo sapiens truncated insulin-like 2 growth factor 2-binding protein 2 (IGF2BP2) mRNA, complete cds, alternatively spliced. ACCESSION EU408704 VERSION EU408704.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 1647) AUTHORS Prokunina-Olsson,L., Hanisch,J.J., Jackson,A., Chines,P.S., Erdos,M.R., Bonnycastle,L.L., Swift,A., Narisu,N., Scott,L.J., Morken,M., Mohlke,K., Bergman,R., Tuomilehto,J., Boehnke,M., Rotimi,C.N., Watanabe,R.N. and Collins,F.S. TITLE A novel type 2 diabetes-associated variant of IGF2BP2 gene affects expression of a functional alternative splicing form JOURNAL Unpublished REFERENCE 2 (bases 1 to 1647) AUTHORS Prokunina-Olsson,L., Hanisch,J.J., Jackson,A., Chines,P.S., Erdos,M.R., Bonnycastle,L.L., Swift,A., Narisu,N., Scott,L.J., Morken,M., Mohlke,K., Bergman,R., Tuomilehto,J., Boehnke,M., Rotimi,C.N., Watanabe,R.N. and Collins,F.S. TITLE Direct Submission JOURNAL Submitted (16-JAN-2008) NHGRI, NIH, 50 South Dr., Bldg. 50, Rm. 5314, Bethesda, MD 20892, USA FEATURES Location/Qualifiers source 1..1647 /db_xref="H-InvDB:HIT000557768" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" /chromosome="3" /map="3q27.2" gene 1..1647 /gene="IGF2BP2" CDS 71..238 /gene="IGF2BP2" /note="IGF2BP2; RNA-binding protein; alternatively spliced; the transcription start site is in intron 2, an alternative exon is spliced into exon 3; also lacks exon 5 resulting in the use of an alternative stop codon in exon 6 producing a non-functional protein due to the lack of all protein domains that are normally present in this protein (2 RNA-recognition motifs (RRM) and 4 K-homology (KH) domains); expressed only in HeLa (cervical carcinoma), HepG2 (hepatocellular carinoma)and MDA435 (metastatic breast cancer) cell lines but not in normal tissues" /codon_start=1 /product="truncated insulin-like 2 growth factor 2-binding protein 2" /protein_id="ACB86628.1" /translation="MFSCPGHYHVDGFLNPGSRKIQIRNIPPHLQWEVLDGLLAQYGT VENVEQEPWRS" BASE COUNT 462 a 435 c 429 g 321 t ORIGIN 1 aggctaaggg agagatagct aatgaccggt attgtgtact gagatcagac ttcagggatg 61 aagcagctgt atgttctcat gtcctggaca ctaccacgtt gatggctttc taaatccagg 121 gagcaggaaa attcagattc gaaacatccc tcctcacctg cagtgggagg tgttggatgg 181 acttttggct caatatggga cagtggagaa tgtggaacaa gagccatgga gaagctaagc 241 gggcatcagt ttgagaacta ctccttcaag atttcctaca tcccggatga agaggtgagc 301 tccccttcgc cccctcagcg agcccagcgt ggggaccact cttcccggga gcaaggccac 361 gcccctgggg gcacttctca ggccagacag attgatttcc cgctgcggat cctggtcccc 421 acccagtttg ttggtgccat catcggaaag gagggcttga ccataaagaa catcactaag 481 cagacccagt cccgggtaga tatccataga aaagagaact ctggagctgc agagaagcct 541 gtcaccatcc atgccacccc agaggggact tctgaagcat gccgcatgat tcttgaaatc 601 atgcagaaag aggcagatga gaccaaacta gccgaagaga ttcctctgaa aatcttggca 661 cacaatggct tggttggaag actgattgga aaagaaggca gaaatttgaa gaaaattgaa 721 catgaaacag ggaccaagat aacaatctca tctttgcagg atttgagcat atacaacccg 781 gaaagaacca tcactgtgaa gggcacagtt gaggcctgtg ccagtgctga gatagagatt 841 atgaagaagc tgcgtgaggc ctttgaaaat gatatgctgg ctgttaacca acaagccaat 901 ctgatcccag ggttgaacct cagcgcactt ggcatctttt caacaggact gtccgtgcta 961 tctccaccag cagggccccg cggagctccc cccgctgccc cctaccaccc cttcactacc 1021 cactccggat acttctccag cctgtacccc catcaccagt ttggcccgtt cccgcatcat 1081 cactcttatc cagagcagga gattgtgaat ctcttcatcc caacccaggc tgtgggcgcc 1141 atcatcggga agaagggggc acacatcaaa cagctggcga gattcgccgg agcctctatc 1201 aagattgccc ctgcggaagg cccagacgtc agcgaaagga tggtcatcat caccgggcca 1261 ccggaagccc agttcaaggc ccagggacgg atctttggga aactgaaaga ggaaaacttc 1321 tttaacccca aagaagaagt gaagctggaa gcgcatatca gagtgccctc ttccacagct 1381 ggccgggtga ttggcaaagg tggcaagacc gtgaacgaac tgcagaactt aaccagtgca 1441 gaagtcatcg tgcctcgtga ccaaacgcca gatgaaaatg aggaagtgat cgtcagaatt 1501 atcgggcact tctttgctag ccagactgca cagcgcaaga tcagggaaat tgtacaacag 1561 gtgaagcagc aggagcagaa ataccctcag ggagtcgcct cacagcgcag caagtgaggc 1621 tcccacaggc accagcaaaa caacgga //