LOCUS       EU408704                1647 bp    mRNA    linear   HUM 07-JUN-2008
DEFINITION  Homo sapiens truncated insulin-like 2 growth factor 2-binding
            protein 2 (IGF2BP2) mRNA, complete cds, alternatively spliced.
ACCESSION   EU408704
VERSION     EU408704.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1647)
  AUTHORS   Prokunina-Olsson,L., Hanisch,J.J., Jackson,A., Chines,P.S.,
            Erdos,M.R., Bonnycastle,L.L., Swift,A., Narisu,N., Scott,L.J.,
            Morken,M., Mohlke,K., Bergman,R., Tuomilehto,J., Boehnke,M.,
            Rotimi,C.N., Watanabe,R.N. and Collins,F.S.
  TITLE     A novel type 2 diabetes-associated variant of IGF2BP2 gene affects
            expression of a functional alternative splicing form
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1647)
  AUTHORS   Prokunina-Olsson,L., Hanisch,J.J., Jackson,A., Chines,P.S.,
            Erdos,M.R., Bonnycastle,L.L., Swift,A., Narisu,N., Scott,L.J.,
            Morken,M., Mohlke,K., Bergman,R., Tuomilehto,J., Boehnke,M.,
            Rotimi,C.N., Watanabe,R.N. and Collins,F.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-JAN-2008) NHGRI, NIH, 50 South Dr., Bldg. 50, Rm.
            5314, Bethesda, MD 20892, USA
FEATURES             Location/Qualifiers
     source          1..1647
                     /db_xref="H-InvDB:HIT000557768"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.2"
     gene            1..1647
                     /gene="IGF2BP2"
     CDS             71..238
                     /gene="IGF2BP2"
                     /note="IGF2BP2; RNA-binding protein; alternatively
                     spliced; the transcription start site is in intron 2, an
                     alternative exon is spliced into exon 3; also lacks exon 5
                     resulting in the use of an alternative stop codon in exon
                     6 producing a non-functional protein due to the lack of
                     all protein domains that are normally present in this
                     protein (2 RNA-recognition motifs (RRM) and 4 K-homology
                     (KH) domains); expressed only in HeLa (cervical
                     carcinoma), HepG2 (hepatocellular carinoma)and MDA435
                     (metastatic breast cancer) cell lines but not in normal
                     tissues"
                     /codon_start=1
                     /product="truncated insulin-like 2 growth factor 2-binding
                     protein 2"
                     /protein_id="ACB86628.1"
                     /translation="MFSCPGHYHVDGFLNPGSRKIQIRNIPPHLQWEVLDGLLAQYGT
                     VENVEQEPWRS"
BASE COUNT          462 a          435 c          429 g          321 t
ORIGIN      
        1 aggctaaggg agagatagct aatgaccggt attgtgtact gagatcagac ttcagggatg
       61 aagcagctgt atgttctcat gtcctggaca ctaccacgtt gatggctttc taaatccagg
      121 gagcaggaaa attcagattc gaaacatccc tcctcacctg cagtgggagg tgttggatgg
      181 acttttggct caatatggga cagtggagaa tgtggaacaa gagccatgga gaagctaagc
      241 gggcatcagt ttgagaacta ctccttcaag atttcctaca tcccggatga agaggtgagc
      301 tccccttcgc cccctcagcg agcccagcgt ggggaccact cttcccggga gcaaggccac
      361 gcccctgggg gcacttctca ggccagacag attgatttcc cgctgcggat cctggtcccc
      421 acccagtttg ttggtgccat catcggaaag gagggcttga ccataaagaa catcactaag
      481 cagacccagt cccgggtaga tatccataga aaagagaact ctggagctgc agagaagcct
      541 gtcaccatcc atgccacccc agaggggact tctgaagcat gccgcatgat tcttgaaatc
      601 atgcagaaag aggcagatga gaccaaacta gccgaagaga ttcctctgaa aatcttggca
      661 cacaatggct tggttggaag actgattgga aaagaaggca gaaatttgaa gaaaattgaa
      721 catgaaacag ggaccaagat aacaatctca tctttgcagg atttgagcat atacaacccg
      781 gaaagaacca tcactgtgaa gggcacagtt gaggcctgtg ccagtgctga gatagagatt
      841 atgaagaagc tgcgtgaggc ctttgaaaat gatatgctgg ctgttaacca acaagccaat
      901 ctgatcccag ggttgaacct cagcgcactt ggcatctttt caacaggact gtccgtgcta
      961 tctccaccag cagggccccg cggagctccc cccgctgccc cctaccaccc cttcactacc
     1021 cactccggat acttctccag cctgtacccc catcaccagt ttggcccgtt cccgcatcat
     1081 cactcttatc cagagcagga gattgtgaat ctcttcatcc caacccaggc tgtgggcgcc
     1141 atcatcggga agaagggggc acacatcaaa cagctggcga gattcgccgg agcctctatc
     1201 aagattgccc ctgcggaagg cccagacgtc agcgaaagga tggtcatcat caccgggcca
     1261 ccggaagccc agttcaaggc ccagggacgg atctttggga aactgaaaga ggaaaacttc
     1321 tttaacccca aagaagaagt gaagctggaa gcgcatatca gagtgccctc ttccacagct
     1381 ggccgggtga ttggcaaagg tggcaagacc gtgaacgaac tgcagaactt aaccagtgca
     1441 gaagtcatcg tgcctcgtga ccaaacgcca gatgaaaatg aggaagtgat cgtcagaatt
     1501 atcgggcact tctttgctag ccagactgca cagcgcaaga tcagggaaat tgtacaacag
     1561 gtgaagcagc aggagcagaa ataccctcag ggagtcgcct cacagcgcag caagtgaggc
     1621 tcccacaggc accagcaaaa caacgga
//