LOCUS EU362990 2459 bp mRNA linear HUM 16-MAR-2009
DEFINITION Homo sapiens mu opioid receptor splice variant hMOR-1K1 (OPRM1)
mRNA, complete cds, alternatively spliced.
ACCESSION EU362990
VERSION EU362990.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2459)
AUTHORS Shabalina,S.A., Zaykin,D.V., Gris,P., Ogurtsov,A.Y., Gauthier,J.,
Shibata,K., Tchivileva,I.E., Belfer,I., Mishra,B., Kiselycznyk,C.,
Wallace,M.R., Staud,R., Spiridonov,N.A., Max,M.B., Goldman,D.,
Fillingim,R.B., Maixner,W. and Diatchenko,L.
TITLE Expansion of the human mu-opioid receptor gene architecture: novel
functional variants
JOURNAL Hum. Mol. Genet. 18 (6), 1037-1051 (2009)
PUBMED 19103668
REFERENCE 2 (bases 1 to 2459)
AUTHORS Shabalina,S.A., Ogurtsov,A.Y., Gris,P., Gauthier,J.,
Tchivileva,I.E., Maixner,W. and Diatchenko,L.
TITLE Direct Submission
JOURNAL Submitted (21-DEC-2007) Center of Neurosensory Disorders,
University of North Carolina in Chapel Hill, 2190 Old Dental
Building, Chapel Hill, NC 27599, USA
REFERENCE 3 (bases 1 to 2459)
AUTHORS Shabalina,S.A., Ogurtsov,A.Y., Gris,P., Gauthier,J.,
Tchivileva,I.E., Maixner,W. and Diatchenko,L.
TITLE Direct Submission
JOURNAL Submitted (09-APR-2008) Center of Neurosensory Disorders,
University of North Carolina in Chapel Hill, 2190 Old Dental
Building, Chapel Hill, NC 27599, USA
REMARK Sequence update by submitter
COMMENT On Apr 9, 2008 this sequence version replaced EU362990.1.
FEATURES Location/Qualifiers
source 1..2459
/db_xref="H-InvDB:HIT000484894"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q25.2"
/tissue_type="whole brain"
/PCR_primers="fwd_name: hU2, fwd_seq:
taagcctgaaggaaaggttggaagtat, rev_name: h4L3, rev_seq:
ccactgggtgtcttgcacaaactggac"
gene <1..2459
/gene="OPRM1"
exon <1..1298
/gene="OPRM1"
/number=13
misc_feature 288..391
/gene="OPRM1"
/note="internal ribosome entry site (IRES)"
exon 1299..1653
/gene="OPRM1"
/number=2
CDS 1309..2211
/gene="OPRM1"
/note="GPCR; MOR-1K1; alternatively spliced"
/codon_start=1
/product="mu opioid receptor splice variant hMOR-1K1"
/protein_id="ABY66530.1"
/translation="MKTATNIYIFNLALADALXTSTLPFQSVNYLMGTWPFGTILCKI
VISIDYYNMFTSXFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGL
PVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILR
LKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTV
SWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHP
STANTVDRTNHQLENLEAETAPLP"
exon 1654..2172
/gene="OPRM1"
/number=3a
exon 2173..>2459
/gene="OPRM1"
/number=4
BASE COUNT 731 a 579 c 463 g 683 t
ORIGIN
1 ggctagcatg ctaattaact atgcataacc acgtttcctt tcaccatgtt gaaccctgac
61 ataatttttt tttccacaaa cacctcactc tggagaagga aatgattttt tttaattaaa
121 ataaacatac attggaaata cttagtgcta aaataagcct gaaggaaagg ttggaagtat
181 gatgagtcag aaaactgact gtaaagaaac caattactta acataaaaca ccattaaaga
241 taagccacga aatgtaaggt ctgctgggta ggaaagtggc aaatgcaatg aagcatgtct
301 ttagatcatg caggtctata accaayggtg aatctagcaa aagttatttt ctcttttggg
361 gagaaacttc ttcttattaa aaaaataaaa aatgtttcaa cttcttgagc accaaggtca
421 attattctaa atcttaaaac cacagtttta attttgcttt tttgttggtt tttgtacttt
481 ggagtatttg tctacattat cctttttata tttgccatat ttaaagtcca aactaaaagc
541 aaattatttt ctctcctcaa gttaaatggc tctatctttt tctttaaaat ccattaagaa
601 agtgaaactc ccaaagtaag tccaaaaaaa agcccccaag tctgaaaatg tggagctttt
661 ctggcagtaa tgcagcttct gcaagtattg cagaccagat caggtatcag aattttaaag
721 cttcagtaac aaagctgtcc tattgaccct gaggagattt atgaaatcac tttcctgatg
781 ttattgaaac caaaacactt tcctggacac tgaattcagt cctaaacaaa gggcctccaa
841 ccaacagctg tcttgggctg aatgagttag actcaacctc gtgtgacgga aaaacagtaa
901 acacaagcta acatttaaaa ggaattgatg gcaccgtgta aatcagaagc ccaaggaggg
961 cctggcttca ggtgtggggt tctctctcac gctctcaaat ccacatcctc cggattaggt
1021 ccattttcag acaagctcct ccagcaacta cataccatgc gtcttctcag gtgtgggtcc
1081 tgcaggaaaa ctaatacact ctttgtccat aagtctcaaa ataaactctc actggctctg
1141 gttggaacat gagagcatcc ttgccattca ccatggcccc ggtcactaaa cgtcttcacg
1201 ccctggactg gtaatacagc ctatcccaaa gcacctggac tgagaacggg aaatgagtgg
1261 ttcccagagt gaaactgagg tactattact aaattaagat acaccaagat gaagactgcc
1321 accaacatct acattttcaa ccttgctctg gcagatgcct takccaccag taccctgccc
1381 ttccagagtg tgaattacct aatgggaaca tggccatttg gaaccatcct ttgcaagata
1441 gtgatctcca tagattacta taacatgttc accagcntat tcaccctctg caccatgagt
1501 gttgatcgat acattgcagt ctgccaccct gtcaaggcct tagatttccg tactccccga
1561 aatgccaaaa ttatcaatgt ctgcaactgg atcctctctt cagccattgg tcttcctgta
1621 atgttcatgg ctacaacaaa atacaggcaa ggttccatag attgtacact aacattctct
1681 catccaacct ggtactggga aaacctgctg aagatctgtg ttttcatctt cgccttcatt
1741 atgccagtgc tcatcattac cgtgtgctat ggactgatga tcttgcgcct caagagtgtc
1801 cgcatgctct ctggctccaa agaaaaggac aggaatcttc gaaggatcac caggatggtg
1861 ctggtggtgg tggctgtgtt catcgtctgc tggactccca ttcacattta cgtcatcatt
1921 aaagccttgg ttacaatccc agaaactacg ttccagactg tttcttggca cttctgcatt
1981 gctctaggtt acacaaacag ctgcctcaac ccagtccttt atgcatttct ggatgaaaac
2041 ttcaaacgat gcttcagaga gttctgtatc ccaacctctt ccaacattga gcaacaaaac
2101 tccactcgaa ttcgtcagaa cactagagac cacccctcca cggccaatac agtggataga
2161 actaatcatc agctagaaaa tctggaagca gaaactgctc cgttgcccta acagggtctc
2221 atgccattcc gaccttcacc aagcttagaa gccaccatgt atgtggaagc aggttgcttc
2281 aagaatgtgt aggaggctct aattctctag gaaagtgcct gcttttaggt catccaacct
2341 ctttcctctc tggccactct gctctgcaca ttagagggac agccaaaagt aagtggagca
2401 tttggaagga aaggaatata ccacaccgag gagtccagtt tgtgcaagac acccagtgg
//