LOCUS EU360599 2440 bp mRNA linear HUM 16-MAR-2009
DEFINITION Homo sapiens mu opioid receptor splice variant hMOR-1K2 (OPRM1)
mRNA, complete cds, alternatively spliced.
ACCESSION EU360599
VERSION EU360599.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 2440)
AUTHORS Shabalina,S.A., Zaykin,D.V., Gris,P., Ogurtsov,A.Y., Gauthier,J.,
Shibata,K., Tchivileva,I.E., Belfer,I., Mishra,B., Kiselycznyk,C.,
Wallace,M.R., Staud,R., Spiridonov,N.A., Max,M.B., Goldman,D.,
Fillingim,R.B., Maixner,W. and Diatchenko,L.
TITLE Expansion of the human mu-opioid receptor gene architecture: novel
functional variants
JOURNAL Hum. Mol. Genet. 18 (6), 1037-1051 (2009)
PUBMED 19103668
REFERENCE 2 (bases 1 to 2440)
AUTHORS Shabalina,S.A., Ogurtsov,A.Y., Gris,P., Gauthier,J.,
Tchivileva,I.E., Spiridonov,N.A., Maixner,W. and Diatchenko,L.
TITLE Direct Submission
JOURNAL Submitted (20-DEC-2007) Center of Neurosensory Disorders,
University of North Carolina in Chapel Hill, 2190 Old Dental
Building, Chapel Hill, NC 27599, USA
REFERENCE 3 (bases 1 to 2440)
AUTHORS Shabalina,S.A., Ogurtsov,A.Y., Gris,P., Gauthier,J.,
Tchivileva,I.E., Spiridonov,N.A., Maixner,W. and Diatchenko,L.
TITLE Direct Submission
JOURNAL Submitted (09-APR-2008) Center of Neurosensory Disorders,
University of North Carolina in Chapel Hill, 2190 Old Dental
Building, Chapel Hill, NC 27599, USA
REMARK Sequence update by submitter
COMMENT On Apr 9, 2008 this sequence version replaced EU360599.1.
FEATURES Location/Qualifiers
source 1..2440
/db_xref="H-InvDB:HIT000484892"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="6"
/map="6q25.2"
/tissue_type="whole brain"
/PCR_primers="fwd_name: hU2, fwd_seq:
taagcctgaaggaaaggttggaagtat, rev_name: h4L3, rev_seq:
ccactgggtgtcttgcacaaactggac"
gene 1..2440
/gene="OPRM1"
exon 1..1279
/gene="OPRM1"
/note="exon 13"
misc_feature 288..391
/gene="OPRM1"
/note="internal ribosome entry site (IRES)"
exon 1280..1634
/gene="OPRM1"
/note="exon 2"
CDS 1290..2192
/gene="OPRM1"
/note="GPCR; alternatively spliced"
/codon_start=1
/product="mu opioid receptor splice variant hMOR-1K2"
/protein_id="ABY61366.1"
/translation="MKTATNIYIFNLALADALXTSTLPFQSVNYLMGTWPFGTILCKI
VISIDYYNMFTSXFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGL
PVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILR
LKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTV
SWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHP
STANTVDRTNHQLENLEAETAPLP"
exon 1635..2153
/gene="OPRM1"
/note="exon 3a"
exon 2154..2440
/gene="OPRM1"
/note="exon 4"
BASE COUNT 723 a 577 c 461 g 676 t
ORIGIN
1 ggctagcatg ctaattaact atgcataacc acgtttcctt tcaccatgtt gaaccctgac
61 ataatttttt tttccacaaa cacctcactc tggagaagga aatgattttt tttaattaaa
121 ataaacatac attggaaata cttagtgcta aaataagcct gaaggaaagg ttggaagtat
181 gatgagtcag aaaactgact gtaaagaaac caattactta acataaaaca ccattaaaga
241 taagccacga aatgtaaggt ctgctgggta ggaaagtggc aaatgcaatg aagcatgtct
301 ttagatcatg caggtctata accaayggtg aatctagcaa aagttatttt ctcttttggg
361 gagaaacttc ttcttattaa aaaaataaaa aatgtttcaa cttcttgagc accaaggtca
421 attattctaa atcttaaaac cacagtttta attttgcttt tttgttggtt tttgtacttt
481 ggagtatttg tctacattat cctttttata tttgccatat ttaaagtcca aactaaaagc
541 aaattatttt ctctcctcaa gttaaatggc tctatctttt tctttaaaat ccattaagaa
601 agtgaaactc ccaaagtaag tccaaaaaaa agcccccaag tctgaaaatg tggagctttt
661 ctggcagtaa tgcagcttct gcaagtattg cagaccagat caggtatcag aattttaaag
721 cttcagtaac aaagctgtcc tattgaccct gaggagattt atgaaatcac tttcctgatg
781 ttattgaaac caaaacactt tcctggacac tgaattcagt cctaaacaaa gggcctccaa
841 ccaacagctg tcttgggctg aatgagttag actcaacctc gtgtgacgga aaaacagtaa
901 acacaagcta acatttaaaa ggaattgatg gcaccgtgta aatcagaagc ccaaggaggg
961 cctggcttca ggtgtggggt tctctctcac gctctcaaat ccacatcctc cggattaggt
1021 ccattttcag acaagctcct ccagcaacta cataccatgc gtcttctcag gtgtgggtcc
1081 tgcaggaaaa ctaatacact ctttgtccat aagtctcaaa ataaactctc actggctctg
1141 gttggaacat gagagcatcc ttgccattca ccatggcccc ggtcactaaa cgtcttcacg
1201 ccctggactg gtaatacagc ctatcccaaa gcacctggac tgagaacggg aaatgagtgg
1261 ttcccagagt gaaactgaga tacaccaaga tgaagactgc caccaacatc tacattttca
1321 accttgctct ggcagatgcc ttakccacca gtaccctgcc cttccagagt gtgaattacc
1381 taatgggaac atggccattt ggaaccatcc tttgcaagat agtgatctcc atagattact
1441 ataacatgtt caccagcnta ttcaccctct gcaccatgag tgttgatcga tacattgcag
1501 tctgccaccc tgtcaaggcc ttagatttcc gtactccccg aaatgccaaa attatcaatg
1561 tctgcaactg gatcctctct tcagccattg gtcttcctgt aatgttcatg gctacaacaa
1621 aatacaggca aggttccata gattgtacac taacattctc tcatccaacc tggtactggg
1681 aaaacctgct gaagatctgt gttttcatct tcgccttcat tatgccagtg ctcatcatta
1741 ccgtgtgcta tggactgatg atcttgcgcc tcaagagtgt ccgcatgctc tctggctcca
1801 aagaaaagga caggaatctt cgaaggatca ccaggatggt gctggtggtg gtggctgtgt
1861 tcatcgtctg ctggactccc attcacattt acgtcatcat taaagccttg gttacaatcc
1921 cagaaactac gttccagact gtttcttggc acttctgcat tgctctaggt tacacaaaca
1981 gctgcctcaa cccagtcctt tatgcatttc tggatgaaaa cttcaaacga tgcttcagag
2041 agttctgtat cccaacctct tccaacattg agcaacaaaa ctccactcga attcgtcaga
2101 acactagaga ccacccctcc acggccaata cagtggatag aactaatcat cagctagaaa
2161 atctggaagc agaaactgct ccgttgccct aacagggtct catgccattc cgaccttcac
2221 caagcttaga agccaccatg tatgtggaag caggttgctt caagaatgtg taggaggctc
2281 taattctcta ggaaagtgcc tgcttttagg tcatccaacc tctttcctct ctggccactc
2341 tgctctgcac attagaggga cagccaaaag taagtggagc atttggaagg aaaggaatat
2401 accacaccga ggagtccagt ttgtgcaaga cacccagtgg
//