LOCUS EU236710 6715 bp mRNA linear HUM 21-JUN-2011
DEFINITION Homo sapiens DOCK10.2 (DOCK10.2) mRNA, complete cds.
ACCESSION EU236710
VERSION EU236710.2
KEYWORDS .
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 6715)
AUTHORS Yelo,E., Bernardo,M.V., Gimeno,L., Alcaraz-Garcia,M.J., Majado,M.J.
and Parrado,A.
TITLE Dock10, a novel CZH protein selectively induced by interleukin-4 in
human B lymphocytes
JOURNAL Mol. Immunol. 45 (12), 3411-3418 (2008)
PUBMED 18499258
REFERENCE 2 (bases 1 to 6715)
AUTHORS Alcaraz-Garcia,M.J., Ruiz-Lafuente,N., Sebastian-Ruiz,S.,
Majado,M.J., Gonzalez-Garcia,C., Bernardo,M.V., Alvarez-Lopez,M.R.
and Parrado,A.
TITLE Human and mouse DOCK10 splicing isoforms with alternative first
coding exon usage are differentially expressed in T and B
lymphocytes
JOURNAL Hum. Immunol. 72 (7), 531-537 (2011)
PUBMED 21514340
REFERENCE 3 (bases 1 to 6715)
AUTHORS Parrado,A., Yelo,E., Bernardo,M.V. and Moya-Quiles,M.R.
TITLE Direct Submission
JOURNAL Submitted (19-OCT-2007) Immunology Service, Hospital Virgen de la
Arrixaca, Ctra. Madrid-Cartagena, s/n. El Palmar, Murcia 30120,
Spain
REFERENCE 4 (bases 1 to 6715)
AUTHORS Parrado,A., Alcaraz-Garcia,M.J. and Ruiz-Lafuente,N.
TITLE Direct Submission
JOURNAL Submitted (20-JAN-2010) Immunology Service, Hospital Virgen de la
Arrixaca, Ctra. Madrid-Cartagena, s/n. El Palmar, Murcia 30120,
Spain
REMARK Sequence update by submitter
COMMENT On Jan 20, 2010 this sequence version replaced EU236710.1.
FEATURES Location/Qualifiers
source 1..6715
/db_xref="H-InvDB:HIT000557602"
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q36"
/cell_type="peripheral blood mononuclear cells from normal
individuals"
gene 1..>6715
/gene="DOCK10.2"
5'UTR 1..111
/gene="DOCK10.2"
CDS 112..6654
/gene="DOCK10.2"
/note="zizimin3; contains exons 1-56"
/codon_start=1
/product="DOCK10.2"
/protein_id="ABY70713.2"
/translation="MSFRGKVFKREPSEFWKKRRTVRRVNQEEIHRFSSQEKPRLLEP
LDYETVIEELEKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLL
VKEACKFYSSQWHVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTT
SHSSSKGGGGAGGTGVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMN
FYKDEKISKEPKGCIFLDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWI
HTLNRILQISPEGPLQGRRSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKY
LTETEDTVKTTRNMERLNLFSLDPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIIC
KALNSNLQGCVTENENDPITNIEPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLL
GASVALENGNIDTITPRQSEEPHIKGLPEEWLKFPKQAVFSVSNPHSEIVLVAKIEKV
LMGNIASGAEPYIKNPDSNKYAQKILKSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNV
DRDSRFSPLFRQESSKISTEDLVKLVSDYRRADRISKMQTIPGSLDIAVDNVPLEHPN
CVTSSFIPVKPFNMMAQTEPTVEVEEFVYDSTKYCRPYRVYKNQIYIYPKHLKYDSQK
CFNKARNITVCIEFKNSDEESAKPLKCIYGKPGGPLFTSAAYTAVLHHSQNPDFSDEV
KIELPTQLHEKHHILFSFYHVTCDINAKANAKKKEALETSVGYAWLPLMKHDQIASQE
YNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGKPLFKVSTFVVSTVNTQDPHVNA
FFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMSFLPIILNQLFKVLVQNEEDE
ITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKERTVHEELAKNVTGLLKSN
DSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFPESYQNELDNLVMVLSD
HVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYISMFSSGDLKTLCQY
KFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPEYSVTNEFCRKHF
LIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQIASLYMPLYG
MLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDTSFSKDVLN
SIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIPRPLSLIGSTLRF
DKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVCLQNFRYLGK
RNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQHRSQTLP
IIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQT
HQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPA
DLCGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQ
LIADAGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEH
EKDPEMLVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAE
YLKRKGYWKVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEE
GAMKEDSGMQDTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKK
LSDLYYDIHRSYLKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGL
SEISQRLLKLYADKFGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDR
KTDFEMHHNINRFVFETPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQS
STELNPIEVAIDEMSKKVSELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAF
LEETNAKKYPDNQVKLLKEIFRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDML
SELSTVMNEQITGRDDLSKRGVDQTCTRVISKATPALPTVSISSSAEV"
variation 188
/gene="DOCK10.2"
/note="results in Asn to Ile substitution"
/replace="t"
variation 199
/gene="DOCK10.2"
/note="results in Ile to Phe substitution"
/replace="t"
variation 624
/gene="DOCK10.2"
/replace="a"
variation 1728
/gene="DOCK10.2"
/replace="g"
variation 1968
/gene="DOCK10.2"
/replace="t"
variation 2568
/gene="DOCK10.2"
/replace="c"
variation 3357
/gene="DOCK10.2"
/replace="c"
variation 3720
/gene="DOCK10.2"
/replace="t"
variation 3849
/gene="DOCK10.2"
/replace="g"
variation 4071
/gene="DOCK10.2"
/replace="c"
variation 5115
/gene="DOCK10.2"
/replace="t"
3'UTR 6655..>6715
/gene="DOCK10.2"
BASE COUNT 2105 a 1465 c 1445 g 1700 t
ORIGIN
1 tcccttttta ccaagaagaa agatttgttc agcctggtga cgcttcagaa gagaagagtt
61 taacgacatt gatattttga aatattttgt gactcaaatt atagcaatac gatgagtttt
121 cgagggaagg tttttaaacg ggagcccagt gaattttgga agaagagacg aactgtgagg
181 agagtaaacc aagaagaaat ccacagattt agttctcaag aaaagcctag gcttctcgag
241 cctttggatt atgagactgt cattgaagaa cttgaaaaga cctaccggaa tgatcctctt
301 caagatctct tgttcttccc cagtgatgac ttttcagcag ccacagtttc ctgggatatc
361 cgcacgttgt actcaacagt acctgaagat gcagagcaca aggcagaaaa tttactggtt
421 aaggaggctt gtaaatttta tagttcccag tggcatgtgg taaactacaa atatgaacaa
481 tattctggag acattcgaca gctaccccga gcagaataca aaccagagaa gcttccttca
541 cattcctttg agattgacca tgaagatgct gataaggatg aagataccac ttcccactcg
601 tcttccaagg ggggtggagg agcgggagga actggtgttt tcaagtccgg ctggctctac
661 aaggggaatt ttaacagcac cgtgaacaac accgttactg ttcggtcatt caaaaagcgc
721 tacttccagc tgactcagtt accagataac tcctacatta tgaactttta caaagatgag
781 aaaatatcca aagaacccaa aggatgcatc tttttggatt cctgtacagg agtggtgcag
841 aataacagac taagaaaata tgcctttgaa ttgaaaatga atgatctgac ctattttgtg
901 ctggcagctg aaacagagtc agatatggat gaatggatcc acaccctcaa ccgcattctg
961 caaatcagtc ctgaggggcc cctccaaggg aggaggagca cagagctcac tgatctgggt
1021 ctggattcgc tggataattc tgtaacttgt gaatgcacgc cagaggaaac agattcttca
1081 gagaacaacc tacacgcaga ctttgcaaag tacctcacag aaacagaaga tactgtaaaa
1141 acaactcgaa acatggagag gctaaatctg ttctctctag atccagacat agataccttg
1201 aaacttcaaa aaaaagatct cttggaacct gagtctgtga tcaaaccatt tgaagaaaaa
1261 gctgccaaga gaatcatgat catctgtaaa gccctcaact caaatcttca gggatgtgtt
1321 acggagaatg aaaatgatcc gataacgaat attgagcctt tttttgtgag tgtggcactt
1381 tatgacctca gagacagcag gaagatttct gctgattttc atgtggatct aaaccatgct
1441 gctgtcagac agatgctctt gggggcttct gtggctttgg aaaatggcaa catcgacacc
1501 atcactccaa gacaatcaga agaacctcac atcaagggac ttccagagga atggctaaaa
1561 tttccaaagc aggctgtatt ttctgtaagc aatccacatt ctgaaattgt tttggtggcc
1621 aaaatcgaaa aagtcttgat gggaaacatt gcaagtggtg ccgaacctta tattaagaac
1681 ccagactcca acaagtatgc acaaaagata ctaaaatcca acagacaatt ctgcagcaaa
1741 ttgggaaaat accgtatgcc ttttgcttgg gcagtaagat cagtatttaa ggacaaccag
1801 ggaaatgtgg acagagactc aagattttca ccattgttta gacaagaaag tagcaagatt
1861 tcaactgagg acctagttaa actagtatca gattatagaa gggccgacag aataagcaaa
1921 atgcagacca ttcctggaag cctggatatt gctgttgaca acgttccctt ggagcatcca
1981 aattgtgtaa catcgtcctt tatccctgtc aagcctttca acatgatggc tcaaacagaa
2041 cccacagtgg aggtggaaga atttgtttac gattcaacaa agtattgtcg gccttacaga
2101 gtatataaaa atcaaattta tatttacccc aaacacctca agtatgatag ccagaaatgc
2161 ttcaacaagg cacggaatat aactgtgtgc attgaattca aaaattcaga tgaagaaagt
2221 gccaagcccc tgaagtgtat ttatggaaaa cctggagggc ccctcttcac ctcagccgcc
2281 tacacagcag ttctgcacca ctctcagaat ccggatttct cagatgaggt gaaaattgag
2341 ctaccaacac aactccatga gaaacaccat attttgtttt ctttttatca cgtcacctgt
2401 gacatcaatg caaaagctaa tgccaaaaag aaggaggctc tggaaacgtc agttggatat
2461 gcttggcttc ctctgatgaa acacgatcag atagcttctc aagagtacaa catcccaata
2521 gcaacaagtc tgcctcctaa ttatttaagc tttcaagatt ctgcaagtgg aaagcatggt
2581 gggagtgaca ttaaatgggt tgatggtggc aaaccacttt tcaaagtgtc gacatttgtt
2641 gtatcaacag taaatactca ggatccacat gtgaatgcat ttttccaaga gtgccaaaaa
2701 agagagaaag atatgtctca gtcacctacc tcaaatttca tccgctcttg taagaactta
2761 ttgaatgtgg aaaagattca tgcaatcatg agttttctgc ctataatttt gaatcagctc
2821 ttcaaagttc tggtacagaa tgaggaagat gaaataacta caactgtcac cagggttctg
2881 accgacattg tggccaagtg ccatgaggag cagctggatc attctgtcca gtcatatatt
2941 aagttcgtgt tcaagaccag ggcatgcaag gagaggactg tacatgagga actggctaaa
3001 aatgtgactg gtcttttgaa atcaaatgac tcaacaacag taaagcatgt cctaaagcat
3061 tcctggttct tctttgcaat tatcctaaaa tcgatggcac agcacttgat tgacacaaat
3121 aaaatccagc ttccccggcc tcagagattt cctgaatctt accaaaatga attggacaat
3181 cttgtcatgg tcctatccga ccatgtgatt tggaaataca aggatgcact tgaagaaaca
3241 agaagggcaa accacagcgt tgccagattt ctcaagcgct gctttacatt tatggaccga
3301 gggtatgtgt ttaagatggt caacaattac atcagcatgt tctcctccgg tgaccttaag
3361 accttgtgcc agtataaatt tgattttctt caagaagtat gtcaacatga acactttatc
3421 cctttgtgtc tgcccataag atcagcaaac attccagatc ctttgacacc ttcagaatcg
3481 actcaagagt tacatgcatc agatatgcct gaatattcag tcacaaatga attttgtcgc
3541 aaacacttct taatcggaat tctgctccga gaagttggct ttgccctgca ggaagaccaa
3601 gatgtcagac acttagcttt agctgtccta aaaaatctaa tggctaagca ttcatttgat
3661 gatcgataca gagagccaag aaagcaggcc cagatagcaa gtttatacat gcccctgtac
3721 ggcatgctcc tggacaatat gccaaggatt tatctgaagg acctgtatcc ttttactgtc
3781 aatacatcta atcaggggtc tagagatgat ctaagcacca atggaggatt tcaaagccag
3841 acagctatca aacatgcaaa ctctgtggat acatcatttt ctaaagatgt tttaaattcc
3901 atagcagcat tttcatcaat agctatttct acagtaaacc atgctgactc cagagcatct
3961 ttagcaagtc ttgactccaa tccaagtacc aatgagaaga gcagtgagaa gacggacaac
4021 tgtgaaaaga tcccaagacc cttgtctttg attggctcaa ctcttcgatt tgacaagtta
4081 gatcaagcag aaaccaggag tctcctgatg tgttttcttc acattatgaa aacgatttcg
4141 tacgagactc tgattgccta ctggcagaga gctcccagcc cagaggtgtc cgacttcttc
4201 agcatcttgg acgtttgtct tcaaaatttc agatacctag gaaaacgcaa cataataaga
4261 aaaattgctg ctgcatttaa atttgtgcag tccacccaga acaatggaac tctcaaagga
4321 tccaatcctt cctgccagac atcaggtctc ttgtcacaat ggatgcactc cacttccagt
4381 catgaaggcc ataagcagca cagatcacaa actttaccta taattcgagg caaaaatgca
4441 ctttctaacc ccaaactctt acagatgtta gacaatacca tgaccagcaa ctccaatgaa
4501 atagacatcg tgcatcatgt agacactgag gccaatatag ctacggaggt ttgcctcact
4561 attctggacc tgttatccct cttcacacag actcatcaga gacaactcca acaatgtgac
4621 tgtcaaaatt cattgatgaa aagggtcttt gatacctaca tgctcttttt ccaagtcaat
4681 cagtcagcca cagcgctgaa gcatgtgttt gcctccttga gactgtttgt atgcaagttt
4741 ccttcagcgt tctttcaagg gcctgctgac ctctgtggat cattctgtta cgaagtccta
4801 aaatgctgta accacaggtc acggtcaact cagacagaag cctcagccct tctgtacttt
4861 ttcatgagga agaattttga atttaacaag cagaagtcaa ttgtccggtc ccacttacaa
4921 ctcatcaaag ctgtgagcca gttaatagcc gatgctggga ttggaggctc tcggtttcaa
4981 cattcgcttg caattaccaa taatttcgcc aatggagata agcaaatgaa aaacagcaat
5041 ttcccagcag aggtgaagga cctgactaag cgtataagga ctgttttgat ggccacagct
5101 cagatgaagg agcacgagaa ggaccccgag atgctggtgg atctccagta cagcctggca
5161 aactcctacg caagcactcc tgaactacgc aggacctggc tggaaagtat ggccaagatt
5221 catgccagaa acggagattt atctgaggct gccatgtgtt acatccatat tgctgctctc
5281 attgcagagt atctgaaaag aaagggttac tggaaagtgg aaaagatttg cacagcatcc
5341 ctgctctcgg aggataccca cccctgtgat agcaactcat tactaacaac tcccagtgga
5401 ggaagcatgt tctctatggg atggccagct tttttgagca ttacaccaaa cattaaggaa
5461 gaaggagcga tgaaagagga ttctggaatg caagatacac catacaatga gaatatcctg
5521 gtggagcagc tatacatgtg tgtggagttt ctctggaagt ctgagcgata tgaactcatt
5581 gctgatgtca acaagcccat cattgctgtc tttgagaaac aacgagactt caaaaaattg
5641 tcagatctct actacgacat tcatcggtca tatctgaaag tggcagaggt ggtgaattcg
5701 gagaagcggc tgtttggtcg ctactatcgt gtggcatttt atgggcaggg cttttttgaa
5761 gaagaagaag gtaaagagta tatttataaa gagcctaagc tgacaggtct gtccgagatt
5821 tcccaaagat tactcaagct ctatgcagat aaatttggag cagacaatgt gaagataatc
5881 caggattcca acaaggtaaa ccccaaggat ttggacccca aatatgccta catccaggtg
5941 acctatgtga cgccgttctt tgaggaaaag gaaatcgaag accggaagac agatttcgaa
6001 atgcaccaca acatcaaccg ctttgtcttc gagacaccct tcacgctgtc gggcaagaag
6061 cacggtgggg tggcggagca gtgcaagcgg cggacgatcc tgacaacgag tcacctgttc
6121 ccctacgtga agaagagaat acaagtaatt agccaatcga gcacagaact gaatccaatt
6181 gaagtggcaa ttgacgagat gtccaagaag gtttctgagc ttaatcagct ttgcacaatg
6241 gaagaagtgg acatgatcag actgcagctc aaactgcaag gaagtgtcag cgtgaaggtt
6301 aatgctgggc caatggccta tgcacgagct tttcttgaag aaaccaatgc aaagaagtac
6361 cctgacaacc aagtaaagct tttgaaggag atcttcaggc aatttgcaga tgcatgtggg
6421 caggcccttg acgtgaatga gcgcctcatc aaagaggacc agctggagta ccaggaagaa
6481 ctgaggtccc actacaagga catgctcagc gaactctcca cagtcatgaa tgagcagatt
6541 acgggcaggg acgacctgtc aaagcgcgga gtggaccaaa cctgcactcg agtaattagc
6601 aaagcaactc cggccctacc cacggtctcc atctcatcta gtgctgaagt ctgagggctc
6661 tgcagcatca gacccacctc taagagaact ttctgaattt gcagctaatc tcggg
//