LOCUS       EF692496                2079 bp    mRNA    linear   HUM 26-JUL-2016
DEFINITION  Homo sapiens convertase subtilisin/kexin type 9 preproprotein
            (PCSK9) mRNA, complete cds.
ACCESSION   EF692496
VERSION     EF692496.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2079)
  AUTHORS   Ding,K., McDonough,S.J. and Kullo,I.J.
  TITLE     Evidence for positive selection in the C-terminal domain of the
            cholesterol metabolism gene PCSK9 based on phylogenetic analysis in
            14 primate species
  JOURNAL   PLoS ONE 2 (10), E1098 (2007)
   PUBMED   17971861
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2079)
  AUTHORS   Ding,K., McDonough,S.J. and Kullo,I.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-JUN-2007) Division of Cardiovascular Diseases, Mayo
            Clinic, 200 First Street Southwest, Rochester, MN 55905, USA
FEATURES             Location/Qualifiers
     source          1..2079
                     /db_xref="H-InvDB:HIT000469861"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..2079
                     /gene="PCSK9"
     CDS             1..2079
                     /gene="PCSK9"
                     /codon_start=1
                     /product="convertase subtilisin/kexin type 9
                     preproprotein"
                     /protein_id="ABV59216.1"
                     /translation="MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLA
                     LRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQA
                     ARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLER
                     ITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHR
                     QASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQL
                     VQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVI
                     TVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHV
                     AGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHG
                     AGWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLV
                     CRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHW
                     EVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTV
                     ACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEEAVTAVAICCRSR
                     HLAQASQELQ"
BASE COUNT          369 a          682 c          681 g          347 t
ORIGIN      
        1 atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg
       61 ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag
      121 ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc
      181 acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg
      241 gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc
      301 caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct
      361 ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc
      421 gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg
      481 attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg
      541 gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc
      601 atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc
      661 agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc
      721 gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg
      781 gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg
      841 gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc
      901 tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac
      961 gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat
     1021 gcccaggacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac
     1081 ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg
     1141 tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg
     1201 tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc
     1261 aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg
     1321 gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgtg
     1381 tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat
     1441 gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg
     1501 gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc
     1561 tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca
     1621 ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca
     1681 ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg
     1741 ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc
     1801 tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag
     1861 caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg
     1921 acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac
     1981 gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg
     2041 agccggcacc tggcgcaggc ctcccaggag ctccagtga
//