LOCUS EF692496 2079 bp mRNA linear HUM 26-JUL-2016 DEFINITION Homo sapiens convertase subtilisin/kexin type 9 preproprotein (PCSK9) mRNA, complete cds. ACCESSION EF692496 VERSION EF692496.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 2079) AUTHORS Ding,K., McDonough,S.J. and Kullo,I.J. TITLE Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species JOURNAL PLoS ONE 2 (10), E1098 (2007) PUBMED 17971861 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 2079) AUTHORS Ding,K., McDonough,S.J. and Kullo,I.J. TITLE Direct Submission JOURNAL Submitted (20-JUN-2007) Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA FEATURES Location/Qualifiers source 1..2079 /db_xref="H-InvDB:HIT000469861" /organism="Homo sapiens" /mol_type="mRNA" /db_xref="taxon:9606" gene 1..2079 /gene="PCSK9" CDS 1..2079 /gene="PCSK9" /codon_start=1 /product="convertase subtilisin/kexin type 9 preproprotein" /protein_id="ABV59216.1" /translation="MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLA LRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQA ARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLER ITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDGTRFHR QASKCDSHGTHLAGVVSGRDAGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQL VQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVI TVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHV AGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLVAALPPSTHG AGWQLFCRTVWSAHSGPTRMATAIARCAPDEELLSCSSFSRSGKRRGERMEAQGGKLV CRAHNAFGGEGVYAIARCCLLPQANCSVHTAPPAEASMGTRVHCHQQGHVLTGCSSHW EVEDLGTHKPPVLRPRGQPNQCVGHREASIHASCCHAPGLECKVKEHGIPAPQEQVTV ACEEGWTLTGCSALPGTSHVLGAYAVDNTCVVRSRDVSTTGSTSEEAVTAVAICCRSR HLAQASQELQ" BASE COUNT 369 a 682 c 681 g 347 t ORIGIN 1 atgggcaccg tcagctccag gcggtcctgg tggccgctgc cactgctgct gctgctgctg 61 ctgctcctgg gtcccgcggg cgcccgtgcg caggaggacg aggacggcga ctacgaggag 121 ctggtgctag ccttgcgttc cgaggaggac ggcctggccg aagcacccga gcacggaacc 181 acagccacct tccaccgctg cgccaaggat ccgtggaggt tgcctggcac ctacgtggtg 241 gtgctgaagg aggagaccca cctctcgcag tcagagcgca ctgcccgccg cctgcaggcc 301 caggctgccc gccggggata cctcaccaag atcctgcatg tcttccatgg ccttcttcct 361 ggcttcctgg tgaagatgag tggcgacctg ctggagctgg ccttgaagtt gccccatgtc 421 gactacatcg aggaggactc ctctgtcttt gcccagagca tcccgtggaa cctggagcgg 481 attacccctc cacggtaccg ggcggatgaa taccagcccc ccgacggagg cagcctggtg 541 gaggtgtatc tcctagacac cagcatacag agtgaccacc gggaaatcga gggcagggtc 601 atggtcaccg acttcgagaa tgtgcccgag gaggacggga cccgcttcca cagacaggcc 661 agcaagtgtg acagtcatgg cacccacctg gcaggggtgg tcagcggccg ggatgccggc 721 gtggccaagg gtgccagcat gcgcagcctg cgcgtgctca actgccaagg gaagggcacg 781 gttagcggca ccctcatagg cctggagttt attcggaaaa gccagctggt ccagcctgtg 841 gggccactgg tggtgctgct gcccctggcg ggtgggtaca gccgcgtcct caacgccgcc 901 tgccagcgcc tggcgagggc tggggtcgtg ctggtcaccg ctgccggcaa cttccgggac 961 gatgcctgcc tctactcccc agcctcagct cccgaggtca tcacagttgg ggccaccaat 1021 gcccaggacc agccggtgac cctggggact ttggggacca actttggccg ctgtgtggac 1081 ctctttgccc caggggagga catcattggt gcctccagcg actgcagcac ctgctttgtg 1141 tcacagagtg ggacatcaca ggctgctgcc cacgtggctg gcattgcagc catgatgctg 1201 tctgccgagc cggagctcac cctggccgag ttgaggcaga gactgatcca cttctctgcc 1261 aaagatgtca tcaatgaggc ctggttccct gaggaccagc gggtactgac ccccaacctg 1321 gtggccgccc tgccccccag cacccatggg gcaggttggc agctgttttg caggactgtg 1381 tggtcagcac actcggggcc tacacggatg gccacagcca tcgcccgctg cgccccagat 1441 gaggagctgc tgagctgctc cagtttctcc aggagtggga agcggcgggg cgagcgcatg 1501 gaggcccaag ggggcaagct ggtctgccgg gcccacaacg cttttggggg tgagggtgtc 1561 tacgccattg ccaggtgctg cctgctaccc caggccaact gcagcgtcca cacagctcca 1621 ccagctgagg ccagcatggg gacccgtgtc cactgccacc aacagggcca cgtcctcaca 1681 ggctgcagct cccactggga ggtggaggac cttggcaccc acaagccgcc tgtgctgagg 1741 ccacgaggtc agcccaacca gtgcgtgggc cacagggagg ccagcatcca cgcttcctgc 1801 tgccatgccc caggtctgga atgcaaagtc aaggagcatg gaatcccggc ccctcaggag 1861 caggtgaccg tggcctgcga ggagggctgg accctgactg gctgcagtgc cctccctggg 1921 acctcccacg tcctgggggc ctacgccgta gacaacacgt gtgtagtcag gagccgggac 1981 gtcagcacta caggcagcac cagcgaagag gccgtgacag ccgttgccat ctgctgccgg 2041 agccggcacc tggcgcaggc ctcccaggag ctccagtga //