LOCUS       EF589546                 642 bp    mRNA    linear   HUM 23-JAN-2017
DEFINITION  Homo sapiens clone AL-153L immunoglobulin lambda 6 light chain
            mRNA, partial cds.
ACCESSION   EF589546
VERSION     EF589546.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 642)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 642)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
FEATURES             Location/Qualifiers
     source          1..642
                     /db_xref="H-InvDB:HIT000469365"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-153L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>642
                     /codon_start=1
                     /product="immunoglobulin lambda 6 light chain"
                     /protein_id="ABU90707.1"
                     /translation="NFMLTQPHSVSESPGKTVTISCTRSSGYIASNYVQWYQQRPGKT
                     PTTVIFEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDGSIVAFG
                     GGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
                     AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE"
     V_region        1..299
                     /note="IGLV6-57*01"
     misc_feature    1..75
                     /note="FR1-IMGT"
     misc_feature    76..99
                     /note="CDR1-IMGT"
     misc_feature    100..150
                     /note="FR2-IMGT"
     misc_feature    151..159
                     /note="CDR2-IMGT"
     misc_feature    160..273
                     /note="FR3-IMGT"
     misc_feature    274..299
                     /note="CDR3-IMGT"
     J_segment       292..331
                     /allele="IGLJ3*02"
     misc_feature    300..331
                     /note="FR4-IMGT"
     C_region        331..642
                     /allele="IGLC3*04"
BASE COUNT          151 a          201 c          169 g          121 t
ORIGIN      
        1 aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc
       61 tcctgcactc gcagcagtgg ctacattgcc agcaactatg tccagtggta ccagcagcgc
      121 ccgggcaaaa cacccaccac tgtgatattt gaggataacc aaagaccctc tggggtccct
      181 gatcggttct ctggctccat cgacagctcc tccaattctg cctccctcac catctctgga
      241 ctgaagactg aggacgaggc tgactactat tgtcagtctt atgatggcag cattgtggct
      301 ttcggcggag ggaccaagct gaccgtcctg ggtcagccca aggctgcccc ctcggtcact
      361 ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata
      421 agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag
      481 gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc
      541 tacctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg
      601 catgaaggga gcaccgtgga gaagacagtg gcccctacag aa
//