LOCUS       EF589525                 648 bp    mRNA    linear   HUM 23-JAN-2017
DEFINITION  Homo sapiens clone AL-134L immunoglobulin lambda 6 light chain
            mRNA, partial cds.
ACCESSION   EF589525
VERSION     EF589525.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
FEATURES             Location/Qualifiers
     source          1..648
                     /db_xref="H-InvDB:HIT000469344"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-134L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>648
                     /codon_start=1
                     /product="immunoglobulin lambda 6 light chain"
                     /protein_id="ABU90686.1"
                     /translation="NFMLTQPHSVSESPEKTVTISCTRSSGSIANNYVQWYRQRPGSS
                     PTTVIYEDNQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDSSNWVFG
                     GGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
                     AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..300
                     /note="IGLV6-57*01"
     misc_feature    1..75
                     /note="FR1-IMGT"
     misc_feature    76..99
                     /note="CDR1-IMGT"
     misc_feature    100..150
                     /note="FR2-IMGT"
     misc_feature    151..159
                     /note="CDR2-IMGT"
     misc_feature    160..273
                     /note="FR3-IMGT"
     misc_feature    274..300
                     /note="CDR3-IMGT"
     J_segment       293..331
                     /allele="IGLJ3*02"
     misc_feature    301..331
                     /note="FR4-IMGT"
     C_region        331..648
                     /allele="IGLC3*04"
BASE COUNT          153 a          205 c          170 g          120 t
ORIGIN      
        1 aattttatgc tgactcagcc ccactctgtg tcggagtctc cggagaagac ggtaaccatc
       61 tcctgcaccc gcagcagtgg cagcattgcc aacaactatg tgcagtggta ccggcagcgc
      121 ccgggcagtt cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct
      181 gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga
      241 ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagcag caattgggtg
      301 ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact
      361 ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata
      421 agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag
      481 gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc
      541 tacctgagcc tgacgcctga gcagtggaag tcccacaaaa gctacagctg ccaggtcacg
      601 catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca
//