LOCUS       EF589499                 651 bp    mRNA    linear   HUM 23-JAN-2017
DEFINITION  Homo sapiens clone AL-110L immunoglobulin lambda 6 light chain
            mRNA, partial cds.
ACCESSION   EF589499
VERSION     EF589499.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 651)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 651)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
FEATURES             Location/Qualifiers
     source          1..651
                     /db_xref="H-InvDB:HIT000469318"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-110L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>651
                     /codon_start=1
                     /product="immunoglobulin lambda 6 light chain"
                     /protein_id="ABU90660.1"
                     /translation="NFMLTQPHSVSESPGKTVTISCTGSSGSFVSNYVQWYQQRPGSA
                     PITVIYEDNQRPSGVPDRFSGSIDRSSNSASLTISGLKTEDEADYYCQSYDSSNPWVF
                     GGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPV
                     KAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..303
                     /note="IGLV6-57*01"
     misc_feature    1..75
                     /note="FR1-IMGT"
     misc_feature    76..99
                     /note="CDR1-IMGT"
     misc_feature    100..150
                     /note="FR2-IMGT"
     misc_feature    151..159
                     /note="CDR2-IMGT"
     misc_feature    160..273
                     /note="FR3-IMGT"
     misc_feature    274..303
                     /note="CDR3-IMGT"
     J_segment       296..334
                     /allele="IGLJ3*02"
     misc_feature    304..334
                     /note="FR4-IMGT"
     C_region        334..651
                     /allele="IGLC3*04"
BASE COUNT          151 a          201 c          174 g          125 t
ORIGIN      
        1 aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc
       61 tcctgcaccg gcagcagtgg cagctttgtc agcaactatg tgcagtggta ccagcagcgc
      121 ccgggcagtg cccccatcac tgtgatctat gaggataacc aaagaccctc tggggtccct
      181 gatcggttct ctggctccat cgacaggtcc tccaactctg cctccctcac catctctgga
      241 ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagtag caatccttgg
      301 gtgttcggcg gagggaccaa gctgaccgtc ttaggtcagc ccaaggctgc cccctcggtc
      361 actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc
      421 ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc
      481 aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc
      541 agctacctga gcctgacgcc tgagcagtgg aagtcccaca aaagctacag ctgccaggtc
      601 acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a
//