LOCUS       EF589464                 642 bp    mRNA    linear   HUM 23-JAN-2017
DEFINITION  Homo sapiens clone AL-002L immunoglobulin kappa 1 light chain mRNA,
            partial cds.
ACCESSION   EF589464
VERSION     EF589464.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 642)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 642)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
FEATURES             Location/Qualifiers
     source          1..642
                     /db_xref="H-InvDB:HIT000469283"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /clone="AL-002L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>642
                     /codon_start=1
                     /product="immunoglobulin kappa 1 light chain"
                     /protein_id="ABU90625.1"
                     /translation="DIQMTQSPSSLSASVGDRVSITCQANQDINNYLNWYQQKPGKAP
                     KVLIYDASNLEIGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYENLPLTFGGGT
                     KVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
                     ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC"
     V_region        1..290
                     /note="IGKV1D-33*01"
     misc_feature    1..78
                     /note="FR1-IMGT"
     misc_feature    79..96
                     /note="CDR1-IMGT"
     misc_feature    97..147
                     /note="FR2-IMGT"
     misc_feature    148..156
                     /note="CDR2-IMGT"
     misc_feature    157..264
                     /note="FR3-IMGT"
     misc_feature    265..290
                     /note="CDR3-IMGT"
     J_segment       284..322
                     /allele="IGKJ4*01"
     misc_feature    291..322
                     /note="FR4-IMGT"
     C_region        322..642
                     /allele="IGKC*01"
BASE COUNT          182 a          170 c          156 g          134 t
ORIGIN      
        1 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcagc
       61 atcacttgcc aggcgaatca ggacattaac aactatttaa attggtatca gcagaaacca
      121 gggaaagccc ctaaggtcct gatctacgat gcatccaatt tggaaatagg ggtcccatca
      181 aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagtag cctgcagcct
      241 gaagatattg caacatatta ctgtcaacaa tatgagaatc tcccgctcac tttcggcggg
      301 gggaccaagg tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca
      361 tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat
      421 cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag
      481 gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg
      541 ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc
      601 ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt
//