LOCUS       EF589460                 648 bp    mRNA    linear   HUM 22-OCT-2018
DEFINITION  Homo sapiens clone AL-075L immunoglobulin lambda 6 light chain
            mRNA, partial cds.
ACCESSION   EF589460
VERSION     EF589460.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
REFERENCE   3  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-OCT-2018) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
  REMARK    Sequence update by submitter
COMMENT     On Oct 22, 2018 this sequence version replaced EF589460.1.
FEATURES             Location/Qualifiers
     source          1..648
                     /db_xref="H-InvDB:HIT000469279"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-075L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>648
                     /codon_start=1
                     /product="immunoglobulin lambda 6 light chain"
                     /protein_id="ABU90621.2"
                     /translation="NFMLTQPHSVSESPGKTVTISCTRITGSVASNFVQWFQQRPGSS
                     PTTVIYEDDQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDGSTWVFG
                     GGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
                     AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..330
                     /note="IGLV6-57*01"
     misc_feature    1..75
                     /note="FR1-IMGT"
     misc_feature    76..99
                     /note="CDR1-IMGT"
     misc_feature    100..150
                     /note="FR2-IMGT"
     misc_feature    151..159
                     /note="CDR2-IMGT"
     misc_feature    160..273
                     /note="FR3-IMGT"
     misc_feature    274..296
                     /note="CDR3-IMGT"
     C_region        331..648
                     /allele="IGLC3*04"
BASE COUNT          146 a          207 c          171 g          124 t
ORIGIN      
        1 aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc
       61 tcctgcaccc gcatcactgg cagcgttgcc agcaactttg tgcagtggtt ccagcagcgc
      121 ccgggcagtt cccccaccac tgttatctat gaggatgacc aaagaccctc tggggtccct
      181 gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga
      241 ctaaagactg aggacgaggc tgactactac tgtcagtctt atgatggcag cacttgggtg
      301 ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact
      361 ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata
      421 agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag
      481 gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc
      541 tacctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg
      601 catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca
//