LOCUS EF589460 648 bp mRNA linear HUM 22-OCT-2018 DEFINITION Homo sapiens clone AL-075L immunoglobulin lambda 6 light chain mRNA, partial cds. ACCESSION EF589460 VERSION EF589460.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 648) AUTHORS Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G., Connors,L.H., Skinner,M. and Seldin,D.C. TITLE Soft tissue, joint, and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survival JOURNAL Arthritis Rheum. 56 (11), 3858-3868 (2007) PUBMED 17968927 REFERENCE 2 (bases 1 to 648) AUTHORS Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M. TITLE Direct Submission JOURNAL Submitted (02-MAY-2007) Amyloid Treatment and Research Program, Boston University School of Medicine, 715 Albany Street, K-510, Boston, MA 02118, USA REFERENCE 3 (bases 1 to 648) AUTHORS Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M. TITLE Direct Submission JOURNAL Submitted (22-OCT-2018) Amyloid Treatment and Research Program, Boston University School of Medicine, 715 Albany Street, K-510, Boston, MA 02118, USA REMARK Sequence update by submitter COMMENT On Oct 22, 2018 this sequence version replaced EF589460.1. FEATURES Location/Qualifiers source 1..648 /db_xref="H-InvDB:HIT000469279" /organism="Homo sapiens" /mol_type="mRNA" /isolation_source="patient with primary amyloidosis" /db_xref="taxon:9606" /chromosome="22" /clone="AL-075L" /cell_type="plasma cells" /tissue_type="bone marrow" CDS <1..>648 /codon_start=1 /product="immunoglobulin lambda 6 light chain" /protein_id="ABU90621.2" /translation="NFMLTQPHSVSESPGKTVTISCTRITGSVASNFVQWFQQRPGSS PTTVIYEDDQRPSGVPDRFSGSIDSSSNSASLTISGLKTEDEADYYCQSYDGSTWVFG GGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS" V_region 1..330 /note="IGLV6-57*01" misc_feature 1..75 /note="FR1-IMGT" misc_feature 76..99 /note="CDR1-IMGT" misc_feature 100..150 /note="FR2-IMGT" misc_feature 151..159 /note="CDR2-IMGT" misc_feature 160..273 /note="FR3-IMGT" misc_feature 274..296 /note="CDR3-IMGT" C_region 331..648 /allele="IGLC3*04" BASE COUNT 146 a 207 c 171 g 124 t ORIGIN 1 aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc 61 tcctgcaccc gcatcactgg cagcgttgcc agcaactttg tgcagtggtt ccagcagcgc 121 ccgggcagtt cccccaccac tgttatctat gaggatgacc aaagaccctc tggggtccct 181 gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga 241 ctaaagactg aggacgaggc tgactactac tgtcagtctt atgatggcag cacttgggtg 301 ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact 361 ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata 421 agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag 481 gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc 541 tacctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg 601 catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca //