LOCUS       EF589459                 648 bp    mRNA    linear   HUM 23-JAN-2017
DEFINITION  Homo sapiens clone AL-074L immunoglobulin lambda 6 light chain
            mRNA, partial cds.
ACCESSION   EF589459
VERSION     EF589459.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
FEATURES             Location/Qualifiers
     source          1..648
                     /db_xref="H-InvDB:HIT000469278"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-074L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>648
                     /codon_start=1
                     /product="immunoglobulin lambda 6 light chain"
                     /protein_id="ABU90620.1"
                     /translation="NFQLTQVHSVSESPGKTVTITCTHSDGNIASDFVQWYQQRPGSA
                     PATVIFDDDQRPSGVPDRFSGSIDRSSNSASLTISGLKTEDEADYYCQSSHGSTWVLG
                     GGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
                     AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..363
                     /note="IGLV6-57*01"
     misc_feature    1..75
                     /note="FR1-IMGT"
     misc_feature    76..99
                     /note="CDR1-IMGT"
     misc_feature    100..150
                     /note="FR2-IMGT"
     misc_feature    151..159
                     /note="CDR2-IMGT"
     misc_feature    160..273
                     /note="FR3-IMGT"
     misc_feature    274..363
                     /note="CDR3-IMGT"
     J_segment       293..331
                     /allele="IGLJ3*02"
     C_region        331..648
                     /allele="IGLC3*04"
     misc_feature    complement(331..364)
                     /note="FR4-IMGT"
BASE COUNT          146 a          208 c          174 g          120 t
ORIGIN      
        1 aatttccagc tgactcaggt ccactctgtg tcggagtctc cggggaagac ggtgaccatc
       61 acctgcaccc acagcgatgg caacattgcc agcgactttg tgcagtggta ccagcagcgc
      121 ccgggcagtg cccccgccac tgtgatcttt gacgatgacc aaagaccctc tggggtccct
      181 gatcgcttct ctggctccat cgacaggtcc tccaactctg cctccctcac catttctgga
      241 ctgaagactg aggacgaggc tgactactac tgtcagtctt ctcatggcag tacttgggtg
      301 ctcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact
      361 ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata
      421 agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag
      481 gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc
      541 tacctgagcc tgacgcctga gcagtggaag tcccacaaaa gctacagctg ccaggtcacg
      601 catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca
//