LOCUS       EF589454                 636 bp    mRNA    linear   HUM 30-OCT-2018
DEFINITION  Homo sapiens clone AL-069L immunoglobulin lambda 3 light chain
            mRNA, partial cds.
ACCESSION   EF589454
VERSION     EF589454.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 636)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 636)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
COMMENT     On Oct 30, 2018 this sequence version replaced EF589454.1.
FEATURES             Location/Qualifiers
     source          1..636
                     /db_xref="H-InvDB:HIT000469273"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-069L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>636
                     /codon_start=1
                     /product="immunoglobulin lambda 3 light chain"
                     /protein_id="ABU90615.2"
                     /translation="SYELTQPPSVSVSPGQTASITCSGDKLGDKYACWYQQKPGQSPV
                     LVIYQASKRPSGIPERFSGSNSGNTATLTISGTQTMDEADYYCQAWDSSTVVFGGGTK
                     LTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVE
                     TTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..318
                     /note="IGLV3-1*01"
     misc_feature    1..66
                     /note="FR1-IMGT"
     misc_feature    67..99
                     /note="CDR1-IMGT"
     misc_feature    94..144
                     /note="FR2-IMGT"
     misc_feature    145..153
                     /note="CDR2-IMGT"
     misc_feature    154..261
                     /note="FR3-IMGT"
     misc_feature    262..288
                     /note="CDR3-IMGT"
     J_segment       281..319
                     /allele="IGLJ3*01"
     misc_feature    289..321
                     /note="FR4-IMGT"
     C_region        319..636
                     /allele="IGLC2*02"
BASE COUNT          155 a          194 c          175 g          112 t
ORIGIN      
        1 tcctatgagc tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc
       61 acctgctctg gagataaatt gggggataaa tatgcttgct ggtatcagca gaagccaggc
      121 cagtcccctg tgctggtcat ctatcaagca agcaagcggc cctcagggat ccctgagcga
      181 ttctctggct ccaactctgg gaacacagcc actctgacca tcagcgggac ccagactatg
      241 gatgaggctg actattactg tcaggcgtgg gacagcagca ctgtggtatt cggcggaggg
      301 accaagctga ccgtcctagg tcagcccaag gctgccccct cggtcactct gttcccgccc
      361 tcctctgagg agcttcaagc caacaaggcc acactggtgt gtctcataag tgacttctac
      421 ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag
      481 accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta tctgagcctg
      541 acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca tgaagggagc
      601 accgtggaga agacagtggc ccctacagaa tgttca
//