LOCUS EF589429 648 bp mRNA linear HUM 12-OCT-2018 DEFINITION Homo sapiens clone AL-049L immunoglobulin lambda 2 light chain mRNA, partial cds. ACCESSION EF589429 VERSION EF589429.2 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 1 to 648) AUTHORS Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G., Connors,L.H., Skinner,M. and Seldin,D.C. TITLE Soft tissue, joint, and bone manifestations of AL amyloidosis: clinical presentation, molecular features, and survival JOURNAL Arthritis Rheum. 56 (11), 3858-3868 (2007) PUBMED 17968927 REFERENCE 2 (bases 1 to 648) AUTHORS Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M. TITLE Direct Submission JOURNAL Submitted (02-MAY-2007) Amyloid Treatment and Research Program, Boston University School of Medicine, 715 Albany Street, K-510, Boston, MA 02118, USA COMMENT On Oct 12, 2018 this sequence version replaced EF589429.1. FEATURES Location/Qualifiers source 1..648 /db_xref="H-InvDB:HIT000469248_03" /organism="Homo sapiens" /mol_type="mRNA" /isolation_source="patient with primary amyloidosis" /db_xref="taxon:9606" /chromosome="22" /clone="AL-049L" /cell_type="plasma cells" /tissue_type="bone marrow" CDS <1..>648 /codon_start=1 /product="immunoglobulin lambda 2 light chain" /protein_id="ABU90590.2" /translation="QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGK APKLMIFDVSNRPSGVSHRFSGSKSDNTASLTISGLQAEDEADYYCSSYTSSSTWVFG GGTEVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS" V_region 1..330 /note="IGLV2-14*01" misc_feature 1..75 /note="FR1-IMGT" misc_feature 76..102 /note="CDR1-IMGT" misc_feature 103..153 /note="FR2-IMGT" misc_feature 154..162 /note="CDR2-IMGT" misc_feature 163..270 /note="FR3-IMGT" misc_feature 271..300 /note="CDR3-IMGT" J_segment 293..331 /allele="IGLJ3*02" misc_feature 301..333 /note="FR4-IMGT" C_region 331..648 /allele="IGLC3*04" BASE COUNT 149 a 203 c 169 g 127 t ORIGIN 1 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 61 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 121 cacccaggca aagcccccaa actcatgatt tttgatgtca gtaatcggcc ctcaggggtt 181 tctcatcgct tctctggctc caagtctgac aacacggcct ccctgaccat ctctgggctc 241 caggctgaag acgaggctga ttattactgc agctcatata caagcagcag cacttgggtg 301 ttcggcggag ggaccgaggt gaccgtccta ggtcagccca aggctgcccc ctcggtcact 361 ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata 421 agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag 481 gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc 541 tacctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg 601 catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca //