LOCUS       EF589429                 648 bp    mRNA    linear   HUM 12-OCT-2018
DEFINITION  Homo sapiens clone AL-049L immunoglobulin lambda 2 light chain
            mRNA, partial cds.
ACCESSION   EF589429
VERSION     EF589429.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 648)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
COMMENT     On Oct 12, 2018 this sequence version replaced EF589429.1.
FEATURES             Location/Qualifiers
     source          1..648
                     /db_xref="H-InvDB:HIT000469248_03"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-049L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>648
                     /codon_start=1
                     /product="immunoglobulin lambda 2 light chain"
                     /protein_id="ABU90590.2"
                     /translation="QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGK
                     APKLMIFDVSNRPSGVSHRFSGSKSDNTASLTISGLQAEDEADYYCSSYTSSSTWVFG
                     GGTEVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
                     AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..330
                     /note="IGLV2-14*01"
     misc_feature    1..75
                     /note="FR1-IMGT"
     misc_feature    76..102
                     /note="CDR1-IMGT"
     misc_feature    103..153
                     /note="FR2-IMGT"
     misc_feature    154..162
                     /note="CDR2-IMGT"
     misc_feature    163..270
                     /note="FR3-IMGT"
     misc_feature    271..300
                     /note="CDR3-IMGT"
     J_segment       293..331
                     /allele="IGLJ3*02"
     misc_feature    301..333
                     /note="FR4-IMGT"
     C_region        331..648
                     /allele="IGLC3*04"
BASE COUNT          149 a          203 c          169 g          127 t
ORIGIN      
        1 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc
       61 tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa
      121 cacccaggca aagcccccaa actcatgatt tttgatgtca gtaatcggcc ctcaggggtt
      181 tctcatcgct tctctggctc caagtctgac aacacggcct ccctgaccat ctctgggctc
      241 caggctgaag acgaggctga ttattactgc agctcatata caagcagcag cacttgggtg
      301 ttcggcggag ggaccgaggt gaccgtccta ggtcagccca aggctgcccc ctcggtcact
      361 ctgttcccgc cctcctctga ggagcttcaa gccaacaagg ccacactggt gtgtctcata
      421 agtgacttct acccgggagc cgtgacagtg gcctggaagg cagatagcag ccccgtcaag
      481 gcgggagtgg agaccaccac accctccaaa caaagcaaca acaagtacgc ggccagcagc
      541 tacctgagcc tgacgcctga gcagtggaag tcccacagaa gctacagctg ccaggtcacg
      601 catgaaggga gcaccgtgga gaagacagtg gcccctacag aatgttca
//