LOCUS       EF589407                 651 bp    mRNA    linear   HUM 30-OCT-2018
DEFINITION  Homo sapiens clone AL-030L immunoglobulin lambda 2 light chain
            mRNA, partial cds.
ACCESSION   EF589407
VERSION     EF589407.2
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 651)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 651)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
COMMENT     On Oct 30, 2018 this sequence version replaced EF589407.1.
FEATURES             Location/Qualifiers
     source          1..651
                     /db_xref="H-InvDB:HIT000469226_02"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-030L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>651
                     /codon_start=1
                     /product="immunoglobulin lambda 2 light chain"
                     /protein_id="ABU90568.2"
                     /translation="QSALTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQHHPGK
                     APKFMIYDVSQRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTGSSTYVLF
                     GGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPV
                     KAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..333
                     /note="IGLV2-14*01"
     misc_feature    1..75
                     /note="FR1-IMGT"
     misc_feature    76..102
                     /note="CDR1-IMGT"
     misc_feature    103..153
                     /note="FR2-IMGT"
     misc_feature    154..162
                     /note="CDR2-IMGT"
     misc_feature    163..270
                     /note="FR3-IMGT"
     misc_feature    271..302
                     /note="CDR3-IMGT"
     J_segment       296..334
                     /allele="IGLJ3*02"
     misc_feature    303..336
                     /note="FR4-IMGT"
     C_region        334..651
                     /allele="IGLC2*03"
BASE COUNT          150 a          205 c          168 g          128 t
ORIGIN      
        1 cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc
       61 tcctgcactg gaaccagcag tgacgttggt ggttataact atgtctcctg gtaccaacat
      121 cacccaggca aagcccccaa attcatgatt tatgatgtca gtcagcggcc ctcaggggtt
      181 tctaatcgct tctctggctc caagtctggc aacacggcct ccctgaccat ctctgggctc
      241 caggctgagg acgaggctga ttattactgc agctcatata caggcagcag cacctatgta
      301 cttttcggcg gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc
      361 actctgttcc cgccctcctc tgaggagctt caagccaaca aggccacact ggtgtgtctc
      421 ataagtgact tctacccggg agccgtgaca gtggcctgga aggcagatag cagccccgtc
      481 aaggcgggag tggagaccac cacaccctcc aaacaaagca acaacaagta cgcggccagc
      541 agctacctga gcctgacgcc tgagcagtgg aagtcccaca gaagctacag ctgccaggtc
      601 acgcatgaag ggagcaccgt ggagaagaca gtggccccta cagaatgttc a
//