LOCUS       EF589400                 642 bp    mRNA    linear   HUM 23-JAN-2017
DEFINITION  Homo sapiens clone AL-020L immunoglobulin lambda 3 light chain
            mRNA, partial cds.
ACCESSION   EF589400
VERSION     EF589400.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 642)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 642)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
FEATURES             Location/Qualifiers
     source          1..642
                     /db_xref="H-InvDB:HIT000469219"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /clone="AL-020L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>642
                     /codon_start=1
                     /product="immunoglobulin lambda 3 light chain"
                     /protein_id="ABU90561.1"
                     /translation="SYELTQPPSVSVSPGQTASITCSGHKLGDTYTCWYQQKPGQSPL
                     LVIYQDNKRPSGIPERFSGSNSGNTATLSISGTQALDEADYFCQAWDSSTANVVFGGG
                     TKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAG
                     VETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS"
     V_region        1..294
                     /note="IGLV3-1*01"
     misc_feature    1..66
                     /note="FR1-IMGT"
     misc_feature    67..99
                     /note="CDR1-IMGT"
     misc_feature    94..144
                     /note="FR2-IMGT"
     misc_feature    145..153
                     /note="CDR2-IMGT"
     misc_feature    154..261
                     /note="FR3-IMGT"
     misc_feature    262..294
                     /note="CDR3-IMGT"
     J_segment       287..325
                     /allele="IGLJ3*01"
     misc_feature    295..325
                     /note="FR4-IMGT"
     C_region        325..642
                     /allele="IGLC2*02"
BASE COUNT          158 a          194 c          172 g          118 t
ORIGIN      
        1 tcctatgagt tgactcagcc accctcagtg tccgtgtccc caggacagac agccagcatc
       61 acctgctccg gacataaatt gggggataca tatacttgtt ggtatcaaca gaagccaggc
      121 cagtcccctc tactggtcat ctatcaagat aataagcgac cctcagggat ccctgagcga
      181 ttctctggct ccaactctgg gaacacagcc actctgagca tcagcgggac ccaggctttg
      241 gatgaggctg actatttctg tcaggcgtgg gacagcagca ctgcgaatgt ggtattcggc
      301 ggagggacca agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc
      361 ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac
      421 ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga
      481 gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg
      541 agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa
      601 gggagcaccg tggagaagac agtggcccct acagaatgtt ca
//