LOCUS       EF589396                 642 bp    mRNA    linear   HUM 23-JAN-2017
DEFINITION  Homo sapiens clone AL-011L immunoglobulin kappa 1 light chain mRNA,
            partial cds.
ACCESSION   EF589396
VERSION     EF589396.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 642)
  AUTHORS   Prokaeva,T., Spencer,B., Kaut,M., Ozonoff,A., Doros,G.,
            Connors,L.H., Skinner,M. and Seldin,D.C.
  TITLE     Soft tissue, joint, and bone manifestations of AL amyloidosis:
            clinical presentation, molecular features, and survival
  JOURNAL   Arthritis Rheum. 56 (11), 3858-3868 (2007)
   PUBMED   17968927
REFERENCE   2  (bases 1 to 642)
  AUTHORS   Prokaeva,T., Spencer,B., Bodi,K.L., Seldin,D.C. and Skinner,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-MAY-2007) Amyloid Treatment and Research Program,
            Boston University School of Medicine, 715 Albany Street, K-510,
            Boston, MA 02118, USA
FEATURES             Location/Qualifiers
     source          1..642
                     /db_xref="H-InvDB:HIT000469215"
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolation_source="patient with primary amyloidosis"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /clone="AL-011L"
                     /cell_type="plasma cells"
                     /tissue_type="bone marrow"
     CDS             <1..>642
                     /codon_start=1
                     /product="immunoglobulin kappa 1 light chain"
                     /protein_id="ABU90557.1"
                     /translation="DIQMTQSPSSLSASVGDRVTITCRASQSINSFLNWYQHKPGKAP
                     NLLIFAASSLQSGVPSRFSGSASGTDFTLTISNLQPEDFATYYCQQSYTTPYTFGQGT
                     KLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
                     ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC"
     V_region        1..290
                     /note="IGKV1D-39*01"
     misc_feature    1..78
                     /note="FR1-IMGT"
     misc_feature    79..96
                     /note="CDR1-IMGT"
     misc_feature    97..147
                     /note="FR2-IMGT"
     misc_feature    148..156
                     /note="CDR2-IMGT"
     misc_feature    157..264
                     /note="FR3-IMGT"
     misc_feature    265..290
                     /note="CDR3-IMGT"
     J_segment       283..322
                     /allele="IGKJ2*01"
     misc_feature    291..322
                     /note="FR4-IMGT"
     C_region        322..642
                     /allele="IGKC*01"
BASE COUNT          174 a          183 c          148 g          137 t
ORIGIN      
        1 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc
       61 atcacttgcc gggcaagtca gagcattaac agctttttaa attggtatca gcacaaacca
      121 gggaaagccc ctaacctcct gatctttgct gcatccagtt tgcaaagtgg ggtcccatct
      181 aggttcagtg gcagtgcatc tggaacagat ttcactctca ccatcagcaa tctccaacct
      241 gaagattttg cgacttacta ctgtcaacag agttacacta ccccgtacac ttttggccag
      301 gggaccaagc tggagatcaa acgaactgtg gctgcaccat ctgtcttcat cttcccgcca
      361 tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat
      421 cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag
      481 gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg
      541 ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc
      601 ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt
//